The most common Class II variant is the F508del variant, which is missing the 508th amino acid in the protein but has an otherwise normal sequence. Loss of this amino acid leads to misfolding of the protein, and the misfolded protein is not properly transported to the membrane. Based on this information, how many nucleotides are deleted in the CFTR allele encoding this variant?

Answers

Answer 1

Answer:

The correct answer is - 3 (two codons of 507th that are U, C, and the first nucleotide of 508th codon U).

Explanation:

Each amino acid is coded by a three-nucleotide base long codon. So in the case of the F508del variant, there is a deletion of three nucleotides that is encoded for phenylalanine amino acid.

In this isoleucine is encoded by 507th codon that is AUG and 508th codon is UUU codes for Isoleucine.

In this case, two codons of 507th are U, C, and the first nucleotide of 508th codon U. So overall three nucleotides are deleted in the F508del variant..


Related Questions

Human belongs to Class of?

Answers

I believe the answer is Mammal . I hope this helps

Which of the following is correct?
Select one:
a. Industry and agriculture both overuse surface water resources.
b. Industry and agriculture both overuse groundwater resources.
c. Industry overuses surface water and agriculture overuses
groundwater.
O d. Industry overuses groundwater and agriculture overuses
surface water

Answers

Hey i think the answer is C :)

Water is a source that is used for various purposes. The industry overuses the surface water, whereas agriculture overuses the groundwater leading to water scarcity. Thus, option C is correct.

What is water scarcity?

Water scarcity is the unavailability of water or can be said as a shortage of water through the regular supplies due to the overuse and excess waste of these resources.

The lack of sufficient amount of water that has been said to be not equal to the demand is a major issue that affects every organism globally. It can lead to economic decline as there will be drought.

Water is used in various fields including the industries for machines and other works, and also in agriculture fields to grow plants and crops. The industry uses the water present on the surfaces like lakes, and rivers, while crops need the water from the wells.

Therefore, option C. the industry and agriculture overuse water.

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Which of the following statements regarding membrane protein function is false? Group of answer choices Membrane proteins act as receptors to molecules like hormones. Membrane proteins serve as enzymes. Membrane proteins form junctions between cells. Membrane proteins transfer genetic information to the cytoplasm.

Answers

Answer:  

Membrane proteins transfer genetic information to the cytoplasm.

Explanation:

Membrane proteins cannot transfer genetic information to the cytoplasm. Genetic information is only in DNA and RNA, and to pass it, RNA has to leave the nucleus and be translated into a protein in the cytoplasm. Once the protein synthesis has finished, the protein may go to the membrane if it has the signal to do it or have a different function. In the membrane, the membrane protein can receive information from other cells and transfer it to the cytoplasm, but never in the shape of genetic information.

how digestion happens in human​

Answers

Explanation:

The muscles of the small intestine mix food with digestive juices from the pancreas, liver, and intestine, and push the mixture forward for further digestion. The walls of the small intestine absorb water and the digested nutrients into your bloodstream.

Answer :Once foods are broken into small enough parts, your body can absorb and move the nutrients to where they are needed. Your large intestine absorbs water, and the waste products of digestion become stool. Nerves and hormones help control the digestive process.

what scenerio in which a population is evolving. Explain how the variants within a population was generated.​

Answers

Genetic variation is an important force in evolution as it allows natural selection to increase or decrease frequency of alleles already in the population. ... Genetic variation is advantageous to a population because it enables some individuals to adapt to the environment while maintaining the survival of the population.

Which process produces a phase change for water molecules? What is the factor that drivers this process?

Answers

Explanation:

I think this is the answer i try to do it

Different types of cells have different numbers and types of
O nuclei
O DNA
O cell membranes
O organelles

Answers

I think organelles

Because only one cell has one nuclei, one set of dna and one set of cell membranes, and organelles I believe are all the guts in the cells. I may be wrong sorry

In pointers dogs, the Punnett square for tail length is below (gene A). Use the Punnett Square below to determine the possible offspring from a cross between two heterozygotes.
F1
A1 A2
A1 A1 A1 A1 A2
Never born Bow-tie tails
A2 A1 A2 A2 A2
Bow-tie tails Long tails
a. In terms of tail length what kind of inheritance does this gene show?
b. In terms of survival what kind of inheritance does this gene show?

Answers

Answer:

a) Autosomal dominant inheritance ⇒ The presence of at least one A1 allele is enough to express Bow-tie tails.

b) Autosomal recessive inheritance ⇒ The presence of at least one recessive allele A2 is enough for individuals to survive.

Explanation:

Due to technical problems, you will find the complete explanation in the attached files.

How are meiosis and mitosis similar?



A.They both produce diploids.

B.They happen at the same time.

C.They both produce sex cells.

D.They both produce new cells.

Answers

Answer:

D.They both produce new cells.

Explanation:

Meiosis and mitosis are both processes of cell division; however, they have many differences. Meiosis occurs in sex cells and produces haploids that can be fertilized. Mitosis occurs in body cells and produces diploids that replace old or damaged cells. Still, both processes result in the creation of new cells.

Answer:

D) They both produce new cells!

Explanation:

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in order for the elodea leaves to photosynthesize need to light and both _______ and ________

Answers

Answer:

Carbon dioxide and Chlorophyll

In order for the elodea leaves to photosynthesize need to light and both Carbon dioxide and Water

Photosynthesis is the process by which green plants and certain other organisms transform light energy into chemical energy.

During photosynthesis in green plants, light energy is captured and used to convert water, carbon dioxide, and minerals into oxygen and energy-rich organic compounds.

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how do humans impact the biodiversity of ecosystems

Answers

Answer:

Humans affect biodiversity by their population numbers, use of land, and their lifestyles, causing damage to habitats for species. Through proper education, and by demanding that governments make decisions to preserve biodiversity, the human population will be able to sustain life on earth longer.

Explanation:

[tex]\texttt{ANSWER:}[/tex]

Human population levels, land usage, and lifestyles all have an impact on biodiversity, causing damage to species' habitats. The human population will be able to maintain life on Earth for longer if adequate knowledge is provided and governments are forced to make decisions that protect biodiversity.

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What is the role of the spindle fibers in mitosis?

Answers

Answer:

Spindle fibers are a type of protein that splits a cell's genetic material. During both kinds of nuclear division, mitosis and meiosis, the spindle is required to evenly divide the chromosomes in a mother cell into two daughter cells. The spindle fibers are referred to as the mitotic spindle during mitosis.

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Predict what will happen to the concentration of pyruvate, NADH and H+ when the Krebs cycle is stopped by arsenic

Answers

Answer: Pyruvate would increase, NADH would decrease, and intermembrane H+ would decrease as well.

Explanation:

Glycolysis would raise pyruvate, but the Krebs Cycle would not produce NADH, decreasing it. No protons (H+) will be pushed into the intermembrane gap, lowering its H+ content and raising its pH.

What is Kreb's cycle?

The tricarboxylic acid (TCA) cycle, commonly referred to as the Krebs cycle or the citric acid cycle, is the primary route that cells use in order to acquire energy and is an essential component of aerobic respiration. The cycle transforms the oxidative potential of acetyl coenzyme A (acetyl CoA) into the reductive potential of nicotinamide adenine dinucleotide (NADH).

The synthesis of ATP via the Krebs cycle is disrupted when arsenic is present because it prevents pyruvate from being converted into acetyl coenzyme A (acetyl-CoA). In addition to the effects described above, arsenic also prevents glucose uptake at the cellular level, as well as gluconeogenesis, the oxidation of fatty acids, and additional acetyl-CoA formation.

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different evolution theory of living organism​

Answers

Answer:

(I) Lamarckism or Theory of Inheritance of Acquired characters.

This theory is based on the comparison between the contemporary species of Jean Baptiste de Lamarck's time to fossil records.

(II) Darwinism or Theory of Natural Selection.

Charles Darwin made an extensive study of nature for over 20 years, especially in 1831-1836 when he went on a voyage on the famous ship “H.M.S. Beagle” and explored South America, the Galapagos Islands and other islands.

(III) Mutation theory of De Vries.

The mutation theory of evolution was proposed by a Dutch botanist, Hugo de Vries (1848-1935 A.D.) in 1901 A.D. in his book entitled “Species and Varieties, Their Origin by Mutation”. He worked on evening primrose (Oenothera lamarckiana).

(IV) Neo-Darwinism or Modern concept or Synthetic theory of evolution.

The detailed studies of Lamarckism, Darwinism and Mutation theory of evolution showed that no single theory is fully satisfactory. Neo-Darwinism is a modified version of theory of Natural Selection and is a sort of reconciliation between Darwin’s and de Vries theories.

Below are portions of a haplotype sequence from three individuals. Each base represents a SNP found at a distinct position in the genome. Which of these haplotypes are most closely related based upon the SNPs provided here?

Haplotype
A 5'...ATCGATAATCCCCTTAG...3
B 5'...ATTGATCATCCCCTAAG...3
C 5'...ATCTATCATCAGATACG...3

a. A, B, and C are all similarly related
b. A and B
c. B and C
d. A and C

Answers

The correct answer is A and B


Match the rocks with the geological processes that create them.
igneous rocks
sedimentary rocks
metamorphic rocks
They are formed when liquid
magma cools and solidifles
beneath or above Earth's
surface.
They are molded by heat and
pressure deep inside Earth.
The heat comes from magma.
Pressure is exerted by the
motion of Earth's plates and
the weight of other rocks.
They are a result of weathering
and lithification, which is often
aided by the flow of water.

Answers

Answer:

Igneous rocks:

-They are formed when liquid magma cools and solidifies beneath or above Earth’s surface.

Sedimentary rocks:

-They are a result if weathering and lithification, which is often aided by the flow of water.

Metamorphic rocks:

-They are molded by heat and pressure deep inside Earth.

-The heat comes from magma.

-Pressure is exerted by the motion of Earth’s plates and the weight of other rocks.

Explanation:

These are all I can do. You gave 5 sentence choices right? Hope this helps!

Answer:

The answer is Igneous rocks, Metamorphic rocks, and Sedimentary rocks

Explanation:

Albinism, lack of pigmentation in humans, results from an autosomal recessive gene. Two parents with normal pigmentation have an albino child. What is the probability that their next three children will be wild type

Answers

Answer:

50

Explanation:

because this disorder occurs when the alleles are recessive meaning the alleles Will be heterozygous

The protein calcineurin binds to the protein calmodulin with an association rate of 8.9 × 103 M-1s-1 and an overall dissociation constant, Kd, of 10 nM. The dissociation rate kd is:_____. Please explain step by step.
A. 8.9 × 10^3 M-1s-1
B. 8.9 × 10^2 s-1
C. 1.1 × 10-10 s-1
D. 8.9 × 10-5 s-1

Answers

Answer:

D

Explanation:

From the information given:

Association rate [tex]K_a[/tex] = [tex]8.9 \times 10^3 M^{-1}s^{-1}[/tex]

dissociation constant [tex]K_D[/tex] = 10 nM

dissociation rate [tex]K_d[/tex] = ???

Using the following relation from equilibrium dissociation constant to determine the dissociation rate, we have:

[tex]K_D =\dfrac{ K_d}{K_a}[/tex]

[tex]K_d = K_D \times K_a[/tex]

[tex]K_d =(10*10^{-9} \ M) \times (8.9*10^3 \ M^{-1}{s^{-1})[/tex]

[tex]\mathbf{K_d =8.9*10^{-5} \ {s^{-1}}}[/tex]

atoms May bond together to make larger what ​

Answers

Atoms bond together to make larger molecules or elements.

Indicate whether each of the following descriptions is true of microtubules (MT), microfilaments (MF), intermediate filaments (IF), or none of these (N). More than one response may be appropriate for some statements.
(a) Involved in muscle contraction.
(b) Involved in the movement of cilia and flagella.
(c) More important for chromosome movements than for cytokinesis.
(d) More important for cytokinesis than for chromosome movements in animal cells.
(e) Most likely to remain when cells are treated with solutions of nonionic detergents or solutions of high ionic strength.
(f) Structurally similar proteins are found in bacterial cells.
(g) Their subunits can bind and catalyze hydrolysis of phosphonucleotides.
(h) Can be detected by immunofluorescence microscopy.
(i) Play well-documented roles in cell movement.
(j) The fundamental repeating subunit is a dimer.
MT,
MF,
IF,
MT and MF,
MT and IF ,
MT, IF, MF.

Answers

Answer:

(a) Microfilaments

(b) Microtubules

(c) Microtubules

(d) Microfilaments

(e) Intermediate filaments

(f) Microfilaments, intermediate filaments, microtubules

(g) Microfilaments, microtubules

(h) Microfilaments, intermediate filaments, microtubules

(i) Microtubules, microfilaments

(j) Microtubules

Explanation:

Microtubules (MTs) are dimers of the protein tubulin (alpha- and beta-tubulin subunits) and they are major components of the cytoskeleton. MTs play diverse cellular roles including, mechanical support (cytoskeleton), transport, motility, chromosome segregation, etc. Microfilaments (MFs) are protein filaments that also form part of the cytoskeleton in eukaryotic cells. MFs consist of G-actin monomers assembled in linear actin polymers, and their functions include mechanical support, cytokinesis, changes in cell shape, amoeboid movement, endocytosis and exocytosis, etc. MFs associate with the protein myosin to generate muscle contractions. Actin filaments/MTs assembly from monomeric actin/tubulin is caused due to energy expenditure, where ATP/GTP bound to actin/tubulin is hydrolyzed during polymerization. Finally, intermediate filaments (IFs) are a type of cytoskeletal element composed of a heterogeneous group of structural elements, and they are not found in all eukaryotes. The primary function of the IFs is to contribute to the mechanical support for the plasma membrane where these filaments come into contact with other cells and/or with the extracellular matrix. The IFs are not directly involved in cell movement. All 3 types of cytoskeletal elements (microfilaments, intermediate filaments, microtubules) can be visualized by fluorescence microscopy when cells express chimeric MT/IF/MF.–GFP fusion proteins.

plz help
and explain why?

Answers

Answer:

steel plate

Explanation:

steel plate have lustre because steel is coated with zinc.

Hope it is helpful....

3 Peroxisomes are cellular organelles: A. with their own genome B. present only in protists C. without membrane OR D. collaborating with the nucleus O E site of some oxidation reactions

Answers

Answer:

E.site of some oxidation reactions

1. ¿Cuáles son las células que contiene la retina?​

Answers

Answer:

Células fotorreceptoras: Son los conos y los bastones. Transforman los impulsos luminosos en señales eléctricas.

Células bipolares de la retina. Conectan las células fotorreceptoras con las células ganglionares.

Células amacrinas. ...

Células horizontales. ...

Células ganglionares de la retina.

what type of feature might be observed at this location?

Answers

Answer:

at what location? the question isnt finished

What are three structural differences between animal and plant cells

Answers

All living things are made up of cells. Cells are the basic unit of a living organism and where all life processes are carried out.

Animal cells and plant cells share the common components of a nucleus, cytoplasm, mitochondria and a cell membrane.

Plant cells have three extra components, a vacuole, chloroplast and a cell wall.

mention two srraigies That favour self pollination​

Answers

There are two types of self-pollination: in autogamy, pollen is transferred to the stigma of the same flower; in geitonogamy, pollen is transferred from the anther of one flower to the stigma of another flower on the same flowering plant, or from microsporangium to ovule within a single (monoecious) gymnosperm

How does wet heat sterilization, such as an autoclave, work to inactivate bacteria and other infectious pathogens?

Answers

Answer and Explanation:

The microorganisms such as bacteria and fungi are basically composed of biological macromolecules (lipids, proteins, polysaccharides). As the temperature increases, the structure of proteins is disrupted and they lose their function. For example, enzymes that catalyze biological reactions are inactivated.

Therefore, wet heat sterilization is a process in which the material is heated during a certain time at a certain high temperature to destroy the microorganisms by producing the denaturation of structural proteins and enzymes.

oxygen is carried by blood to all the cells of body in the form of ___________​

Answers

Answer:

Oxygen is carried by blood to all the cells of the body in the form of haemoglobin.

Explanation:

Oxygen is carried in the blood in two forms:

(1) dissolved in plasma and red blood cells water (about 2% of the total)

(2) reversibly bound to haemoglobin (about 98% of the total).

Haemoglobin is a protein in the red blood cells and carries oxygen around our bodies. At the same time, carbon dioxide that is dissolved in the blood comes out of the capillaries back into the air sacs, ready to be breathed out.

Many of the phenotypes of DiGeorge syndrome have been traced back to one of the genes that is in the deleted region, TBX1. Some of the evidence for the important role of TBX1 in DiGeorge syndrome came from individuals who have some of the symptoms of DiGeorge syndrome without having the typical deletion. Closer examination showed that some of these individuals had SNV in the TBX1 gene. Which of the following SNVS would be most likely to create a similar phenotype to the deletion?
A. A variant in the promoter region of TBX1 that increases its expression
B. A variant in the intronic region of TBX1 that does not affect splicing. X
C. A nonsense variant near the 5' end of the TBX1 gene.
D. A silent variant near the 5' end of the TBX1 gene.

Answers

Answer:

D. A silent variant near the 5' end of the TBX1 gene.

Explanation:

TBX1 gene is wild type human being. It gives instructions for making protein called T-box 1. It plays an important role in tissue formation and organs during embryonic development.

What happens to proteins with no signal sequence that are made in the cytosol? Question 3 options: They are taken up by lysosomes. They are degraded by proteases. They are returned to their organelle of origin. They are secreted. They remain in the cytosol.

Answers

Answer:

The correct answer is: They remain in the cytosol.

Explanation:

Eukaryotic proteins are made through a process called Translation, which always starts at the cytosol (except for the proteins that are made in the mitochondria).

While Translation is taking place, the peptide that is being synthesized is checked for molecular tags that will lead to a re-routing to another destination: proteins that have an amino sequence called 'signal peptide' will be sent to the endoplasmic reticulum for its translation to continue - the proteins that go this route are meant to be part of the endomembrane system, after that they can be bounded to the ER, the Golgi apparatus or the lysosomes.

Unlike the proteins mentioned before, there are proteins that will have no signal peptide - this means that they are meant to finish Translation in the cytosol. Some of these proteins will acquire a signal tag that will lead them to the nucleus or the mitochondria, for example, but if they don't they will stay permanently in the cytosol to perform their tasks in that place.

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Minden Company introduced a new product last year for which it is trying to find an optimal selling price. Marketing studies suggest that the company can increase sales by 5,000 units for each $2 reduction in the selling price. The companys present selling price is $93 per unit, and variable expenses are $63 per unit. Fixed expenses are $830,700 per year. The present annual sales volume (at the $93 selling price) is 25,500 units. Required: 1. What is the present yearly net operating income or loss? 2. What is the present break-even point in unit sales and in dollar sales? 3. Assuming that the marketing studies are correct, what is the maximum annual profit that the company can earn? At how many units and at what selling price per unit would the company generate this profit? how did the supreme court ruling on the civil rights case of 1833 affect the right of african americans?it led to the drafting and passage of the civil rights act it led to a sharp increase in African American votingit opened the door for legal segregation in the southit led to unfair sharecropping contracts in the south por que es importante la participacion How many terms are in the algebraic expressionAlso, What do they mean by "Terms" Glycerin, , is a nonvolatile liquid. What is the vapor pressure of a solution made by adding glycerin to at i need to know soon. HELPPLEASE Which molecule would be the most affected by limited nitrogen?myofibrillar proteins in muscleglucose molecules in starchfat molecules surrounding organscellulose molecules in plant cell walls Given that mabc=70 and mbcd=110. Is it possible (consider all cases): Line AB intersects line CD? HELP. Drag the tiles to the correct boxes to complete the pairs.Match each product of complex numbers with its value. CAN YOU PLEASE HELP MEWhen Pt electrodes are used in the electrolysis of Kl(aq), a number of reactions are possible at the electrodes. Using a standard reduction potentials table predict which reaction is most likely to occur at the anode Pls help ASAP Im really dum I dont get sh Use the Law of Cosines to find the missing angle. If BC = 8.3, CD - 6,7, and AD = 11.6, find AB to the nearest tenth. The loss in the value of an automobile that occurs over its period of ownership is called: Group of answer choices reinsurance. the acquisition payment. the market price. the repurchase commission. depreciation. How do i solve this help me Please help me ASAP!!! Which statement is true?A. All parallelograms are rectangles.B. All parallelograms are quadrilaterals.C. All quadrilaterals are parallelograms.D. All rectangles are squares. Describe how first Aid will be given a lictim under the following accidents at work Shop. Chemical barns Electric shock Fire burns 5) Simplify the 1. (50x+20xy)divide (-5x) What is the distance between the points (2, 1) and (14, 6) on a coordinateplane?