Pharmacokinetics and pharmacodynamics of a new formulation of an investigational drug most likely refers to which clinical phase of a study in humans?

Answers

Answer 1

Answer:

The correct answer is - Phase I.

Explanation:

Clinical phase are group of stages in which scientists or researchers  conduct various experiments with a health intervention to get enough evidence for a process to use as a medical treatment. Clinical research is conducted on medical devices, drug candidates, and vaccine candidates.

In the phase I, in this phase intervention takes place in human subjects. These subject usually observed until several half-lives of the drug have passed. This phase is designed to assess the tolerability, pharmacokinetics, safety (pharmacovigilance), and pharmacodynamics of a drug


Related Questions

What bone marking found on the second cervical vertebra projects superiorly into the anterior portion of the vertebral foramen of the atlas

Answers

Answer:

Odontoid Process

Explanation:

The Axis has a protuberance (process or projection) called the odontoid process. Where it joins the main body of the vertebra, it has a slight constriction or neck. It has an oval or nearly circular facet on its anterior surface for articulation with the anterior arch of the atlas.

Answer:

odontoid process that articulate with concave facet

Explanation:

the concave facet on the anterior arch or C1 to form the atlantoaxial articulation

Help me please I really need this tomorrow

Answers

19. place moth balls in the closet and observe after several days.

20. whenever wax or a candle burns it turns from solid to liquid but again at room temperature it turns to solid

21. evaporation, condensation, precipitation

22. it produces new substances

23. vinegar Bubbles when baking soda is added

24. steam

It is difficult to define Primates according to the presence or absence of certain distinguishing anatomical or behavioral traits. What *really* defines Primates is that they all are descended from a single common ancestor approximately 65 million years ago.

Answers

Answer:

The correct answer is - true.

Explanation:

Primates are the third diverse group of mammals after rodents and bats. It is considered that it has diverged from other terrestrial mammals about 65 million years ago.

Defining and identifying the primates on the basis of certain anatomical and behavioral traits is not an easy task. There are almost 400 living species of primates are known.

a penny is tossed and comes up heads 7 out of 10 times. Is the probability that it will be heads on the next toss 70%? Why or not?​

Answers

Answer:

I think it will because when you express 7/10 as a fraction it will result to 0.7, meaning the probability between 0 and 1 will be 0.7, therefore to express 0.7 as a fraction the answer will be 70%..

sorry if it's wrong

Which of the following statements describes the conditions of a pneumothorax? View Available Hint(s) Which of the following statements describes the conditions of a pneumothorax? The intrapulmonary pressure equalizes to atmospheric pressure. Both lungs partially or completely collapse. The intrapleural pressure decreases. The presence of air in the pleural cavity.

Answers

Answer:

The presence of air in the pleural cavity

Explanation:

A pneumothorax occurs when air builds up between the lung and the chest wall. In consequence, pneumothorax occurs when air gets into the pleural cavity (i.e., the space between the lung and the chest wall) and causes a fully and/or partially collapsed lung. Some of the most common symptoms of pneumothorax include shortness of breath (respiratory distress), rapid breathing, rapid heart rate, fatigue, agitation, dry cough, etc. Pneumothorax can be caused by a chest injury, an accident during a medical procedure, damage from underlying lung diseases, etc.

Earth’s continents are constantly in motion because they sit on top of gigantic plates which float on Earth’s mantle. Energy from the Earth’s core creates convection currents in the molten layer, and the currents move the plates. Over extremely long periods of time, this movement creates new _______.
a.
biomes
b.
plates
c.
atmospheric layers
d.
elements

Answers

Answer:

a. biomes

Explanation:

Ecology can be defined as the scientific study of the relationship between living organisms such as plants and animals in relation to their physical and biological environment.

An ecosystem can be defined as the natural living habitats of both living and non-living organisms, in which they interact with one another. Essential services such as plant pollination, water purification, nutrient cycling etc that are being provided by the ecosystem are really very vital, important and useful for the sustenance of life, both for humans and enhances social welfare.

Generally, the different continents on Earth are in a constant motion due to the fact that they're sitted on top of gigantic plates floating on Earth’s mantle.

Furthermore, the Earth’s core generate energy which also creates convection currents in the molten layer of the Earth, thereby, moving the plates.

Over an extremely long periods of time, the movement of these plates create new biomes.

In Ecology, a biome can be defined as a relatively distinct terrestrial region which is made up of animals, micrograms and plants, and it is typically characterized by similar environmental factors such as wind, relative humidity, rainfall, temperature, etc., irrespective (regardless) of where it occurs in the world.

There are five (5) main types of biomes and these are;

I. Forest.

II. Aquatic.

III. Desert.

IV. Grassland.

V. Tundra.

Answer:

A - Biomes

Explanation:

E2023

Drag the tiles to the boxes to form correct pairs.
Match the scenario with the type of weathering in action.
mechanical weathering
chemical weathering
biological Weathering
The root of a huge tree causes cracks in a rocky surface.
>
Part of a cliff breaks and falls due to waves.
>
Acid rain reacts with calcite present in limestone,

Answers

Answer:

The root of a huge tree causes cracks in a rocky surface. ---> biological Weathering.

Part of a cliff breaks and falls due to waves. ----> mechanical weathering

Acid rain reacts with calcite present in limestone---> chemical weathering

Explanation:

The root of a huge tree causes cracks in a rocky surface is the example of biological Weathering because in this weathering living organism is involved.  Part of a cliff breaks and falls due to waves of water is the example of mechanical weathering because water enters the small pores of rocks and formed cracks when expands.  Acid rain reacts with calcite present in limestone is a chemical weathering because acid present in rain water is responsible for the degradation and breakdown of rocks.

Answer:

how it should loook

Carbohydrates are organic compounds containing chemical bonds used to power cellular processes. Sources of carbohydrates include: (select all that apply)

Answers

Answer:

Bread, beans, milk, popcorn, potatoes, cookies, spaghetti, soft drinks and corn etc.

Explanation:

Bread, beans, milk, popcorn, potatoes, cookies, spaghetti, soft drinks and corn etc are the main sources of carbohydrates. In these foods, carbohydrates are present in large amount which is a quick source of energy for us. The breakdown of carbohydrates starts from the mouth when the food mixes with saliva which contains an enzyme that starts breakdown of carbohydrates into micromolecules is called glucose that can be absorbed by our body for the production of ATP molecules.

why animal-like organisms did not appear on Earth until after the first
organisms that could photosynthesise had appeared.

Answers

Answer:

800 million years ago , these clusters of specialized, cooperating cells eventually became the first animals, which DNA evidence suggests evolved around that time. Sponges were among the earliest animals.

How many capillary beds must a red blood cell pass through to move from an artery in the left arm to the left ventricle of the heart

Answers

Answer:

two capillary beds

Explanation:

Capillary beds are networks of capillaries that supply blood to the organs and/or areas of the body, in which nutrients and gas exchange (i.e., O2 and CO2) between red blood cells and tissues take place. Smaller arteries (i.e., arterioles) diverge into capillary beds composed of 10 to 100 capillaries, the smallest blood vessels in the body that connect the arterioles and the venules. Red blood cells usually flow into a capillary bed from a metarteriole (i.e., a microvessel that connects arterioles and capillaries). Red blood cells sometimes pass through two capillary beds before reaching the heart. The left heart ventricle is a muscle required for pumping red O2-rich blood out through the aortic valve into the aorta, whereas arteries are large blood vessels that branch into arterioles in order to carry blood to the capillary beds.

"All honey flora are plants, but all plants are not honey flora". Justify. ​

Answers

Answer:

Beekeeping is affected by adverse climatic conditions and availability of floral resources. This study aimed to survey and characterize the flora in São João do Piauí, a semi-arid region in Piauí, Brazil, and to identify species providing resources to bees. Flowering plants were observed for 18 months, and records were taken of flowering date, growth habit, visitation and resources collected by bees. Melissopalinological analysis of honey produced in the area was performed. A total of 67 flowering plant species were recorded, of which 49 were considered as bee plants, with a predominance of herbs and shrubs. The low rainfall reduces the number of flowering species, which makes important the conservation and multiplication of species which bloom in dry season, such as Ipomoea glabra, Myracrodruon urundeuva, Sida cordifolia and Ziziphus joazeiro, as well as species that contribute to honey production such as Mimosa tenuiflora, Mesosphaerum suaveolens and Croton sonderianus.

Keywords:

nectar; pollen; floral resources

True or false: Cellular microbes are often arranged in multicellular complexes with differentiated tissues.

Answers

Answer:

False

Explanation:

The perimeter of a rectangle is 16 inches. The equation that represents the perimeter of the rectangle is 2 l plus 2 w equals 16, where l represents the length of the rectangle and w represents the width of the rectangle. Which value is possible for the length of the rectangle?

Answers

Answer:

The perimeter of a rectangle is 16 inches

Explanation:

The equation that represents the perimeter of the rectangle is 2l + 2w = 16, where l represents the length of the rectangle and w represents the width of the rectangle.

10 differences between animal cells and plant cells

Answers

Answer:

Following are the difference to the given question:

Explanation:

Plant cells have a wall of a cell, while cells of animals wouldn't. Cell membranes offer plants support and shape.Chloroplasts in plant cells do not occur, however, in animal cells. Chloroplasts allow plants can grow things via photosynthesizing.Plant cells typically get a vacuole(s) that is one or even more big, whereas animal cells are vacuous, whether any.Large vesicles assist shape the plant and enable food and water to be store for future use.In animal cells, the storing function takes a smaller part and the vacuoles, therefore, are smaller.A plant cell is square in its structural way and an animal cell is often spherical and irregular.The cell of a plant has a vesicle in its big form which is significantly smaller than the plant cell, as well as the animal cell was the or more vacuoles. In general, a vacuole is a storage area for the cells to store water.There is no chloroplast inside the animal cell. Chloroplast is a plant cell that produces photosynthesis from its food. The plants have a green color.The nucleus is located throughout the cell of the plant on the other edge of the peripheral cytoplasm, while the nucleus is in the animal's core.Plant cells store food of starch while animal cells store food of glucose.The mitochondria in the plant are fewer and also have tube cristae, whereas the animal cells have grown in various.

Lee has difficulty seeing the board when he sits at the back of the class. The doctor tells him that he is short-sighted and requires spectacles (glasses).Explain what meant by ‘short-sightedness ‘and how spectacles are used to correct this problem.

it gon be obvious if you copy from g00 gle​

Answers

Shortsightedness refers to the situation where the eyeball becomes to long so therefore light extends the retina and the persons finds it difficult to view things near him.It can be cured by using concave lens

What can our nerves respond to? ​

Answers

They can respond to external stimuli

Most body water comes from:moisture absorbed through the skin.fluids we drink.the food we eat.metabolism.

Answers

Answer:

fluids we drink.

Explanation:

Most body water comes from fluids we drink such as water, juices etc. Our body obtains water by absorbing it directly from the digestive tract. A small amount of water is produced in the metabolism of food particles. Our body loses excess amount of water by excreting it in the form of urine from the body. Kidney is the organ that filters waster materials and excess water from the blood and remove it from the body.

If we poke a plant and an animal cell ,which one of them would lose its shape?

Answers

Answer:

animal cell

Explanation:

hope this will help you

When you did the Homeostasis Exercise Lab yesterday, what was the dependent variable?

A) Heart rate
B) Breathing rate
C) Both Heart rate and Breathing rate
D) Time

Answers

Both heart rate and breathing rate

Select the correct answer from each drop-down menu. Study the graphs, and then complete the passage. An anomaly in global temperature is a deviation from what is normal or expected. The graph shows that global atmospheric co2 ___(increased exponentially. Remained constant. Increased slightly)in the twenty-first century, and global temperature also increased during the same time. Based on the timeline, these statistics suggest a correlation between climate change and ___(wind energy production. Use of electric cars. Industrial carbon emissions). If the current trend of increasing co2 levels continues, the greenhouse effect will continue to ___(warm the planet. Release gas into space. Destroy carbon dioxide) .

Answers

Answer:

Increased exponentially

Industrial carbon emission

Warm the planet

Explanation:

The rapid increase in global CO2 in the 21st century has raised concerns over the lingering effect of global climate change which could result due to the exponential increase in CO2 emission at this time. This rise in global atmospheric CO2 has been observed to have a positive relationship with the level of industrial carbon emission. The rise in emission of industrial carbon has been tipped to be responsible for the exponential rise in global atmospheric CO2. CO2 is a form of green house gas responsible for warming the planet.

Answer:

An anomaly in global temperature is a deviation from what is normal or expected. The graph shows that global atmospheric co2 increased exponentially in the twenty-first century, and global temperature also increased during the same time. Based on the timeline, these statistics suggest a correlation between climate change and Industrial carbon emissions. If the current trend of increasing co2 levels continues, the greenhouse effect will continue to warm the planet.

Explanation:

Plato

what is circulatory system?​

Answers

Answer:

the system that circulates blood and lymph through the body, consisting of the heart, blood vessels, blood, lymph, and the lymphatic vessels and glands.

Explanation:

II. In the food that reaches stomach
a) Name one enzyme that could be
present in it.
b) Name a product of digestion that
could be present in it.


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Answers

Answer:

A) ans: Amylase – helps change starches into sugars. Amylase is found in saliva. Maltase – also found in saliva; breaks the sugar maltose into glucose. Maltose is found in foods such as potatoes, pasta, and beer.

b)ans:The chemical digestion of food is dependent on a whole range of hydrolase enzymes produced by the cells lining the gut as well as associated organs such as the pancreas.

Which is found in both DNA and RNA?
A. thymine
B. uracil
C. adenine
D. ribose

Answers

Answer:

in DNA it is deoxyribose and in RNA it is ribose

Answer:

C. Adenine

Explanation:

DNA and RNA both have adenine, guanine, and cytosine.

DNA has thymine, which RNA does NOT have.

RNA has uracil, which DNA does NOT have.

I need with this question please

Answers

The answer is
C. The way the layer interacts with the layer below it.

An amoeba moves out a large particles by what process?

Answers

Answer:

Exocytosis is the process by which a large number of molecules are released

Cyanide inhibits cytochrome c oxidase, a component of the electron transport chain. If cyanide poisoning occurs, would you expect the pH of the intermembrane space to increase or decrease

Answers

Answer:

Increases.

Explanation:

The pH of the intermembrane space increases as the poisoning of cyanide occurs. After cyanide poisoning, the electron transport chain can stop pumping of electrons into the intermembrane space. The pH of the intermembrane space would increase, the pH gradient would also decreases, and ATP synthesis would stop to occur. The pH of the intermembrane space is neutral i.e. 7 but due to cyanide it move towards basic.

Answer:

Cyanide inhibits cytochrome c oxidase, a component of the electron transport chain. If cyanide poisoning occurs, the pH of the intermembrane space becomes more basic. The electron transport chain can no longer pump hydrogen ions into the intermembrane space and ATP synthesis stops.

write a report on storm around the world​

Answers

The U.S. central plains region -- nicknamed Tornado Alley -- suffers the highest frequency of tornadoes in the world [source: Tarbuck]. Many of these twisters leave death, injury and destruction in their wake, but one stands in a class by itself.

Sweeping out from southeastern Missouri on March 18, 1925, the Tri-State Tornado careened across the southern tip of Illinois before dissipating in lower Indiana. Remarkably, these three locales lie 219 miles (352 kilometers) apart, and the tornado traveled this distance in just three and a half hours [source: SEMP].
With up to 155-mph winds, Hurricane Iota smashed record books on Nov. 16 as the strongest hurricane ever recorded to make landfall in Nicaragua. Iota reached Category 5 strength before making landfall as a Category 4 storm near the town of Haulover, Nicaragua.

The onslaught of destructive winds and heavy rainfall was unfortunately familiar to a region that recently suffered another Category 4 landfalling storm – Hurricane Eta – just two weeks earlier. Eta was a Category 4 storm with 140-mph winds when it landed in Nicaragua on Nov. 3 before ripping a wide path of destruction through Honduras and Guatemala.

Heavy rainfall from these two storm systems brought widespread flooding to the region, triggered large and numerous landslides in Guatemala and Honduras, and was responsible for numerous casualties.

NASA’s Earth Applied Sciences Disasters Program supports disaster response and risk reduction efforts throughout the world — before, during, and after disasters strike – and is working to aid Central America with the impacts from these storms.

In the case of Eta and Iota, the Program is using imagery and data from Earth-observing satellites to provide scientific analysis to Guatemala’s National Coordinator for Disaster Reduction and is working with the Coordination Center for Disaster Prevention in Central America. The multi-agency collaboration is assisting local governments in Nicaragua, Honduras and Guatemala, El Salvador, Belize, Costa Rica, and Panama. The Program is also working with U.S. Southern Command to provide situational awareness for potential emergency humanitarian assistance.

Interactive map

¿Cuál es la molalidad de una disolución al mezclar 4 kg de agua como disolvente con 0,5 Mol de ácido clorhídrico (HCl) como soluto?

Answers

Answer:

La molalidad de la disolución es 0,125 molal.

Explanation:

En la teoría de las disoluciones químicas, la molalidad se define como la cantidad de moles del soluto dividida por la masa de solvente, entonces tenemos que la molalidad de la disolución descrita en el enunciado es:

[tex]m = \frac{0,5\,mol}{4\,kg}[/tex]

[tex]m = 0,125\,m[/tex]

La molalidad de la disolución es 0,125 molal.

Concerning the above image, what region of the eye contains rods/cones?

A) Sclera
B) Optic Nerve
C) Choroid
D) Retina
E) Other:

Answers

Answer:

Retina

Explanation:

The retina has rods and cones.

Rods help us see dim images and comes help us see bright and colored images.

why some fruits have 1 seed and some gruits have many seeds​

Answers

Answer:

Number of seeds in a fruit depends on the number of ovules in an ovary before fertilizations. The fruits which have more seeds in them have more number ovules in the ovary of flowers such as watermelon and those with single seed have only single ovule in the ovary of flowers like mango

Answer:

Number of seeds in a fruit depends on the number of ovules in an ovary before fertilisation. The fruits which have more seeds in them have more number ovules in the ovary of flowers such as watermelon and those with single seed have only single ovule in the ovary of flowers like mango.

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There is a phenomena that worker/capital output has not increased in line with the increased performance capabilities of information technology. What is this phenomena called? - , , , , , , , , , , , , , , , , , , , it very argent please answer me please 4. If matter goes through a chemical change, are the physical properties likely to stay the same? Please say yes or no and explain why. The diagram shows a rectangle. If the perimeter of the rectangle is 66 cm, what is the area of the rectangle? FERNAVNGUATER MATHEMATICSPerformancesNIETheThe Club of Amemetary today on the southpuntered Milk to flevere the readed the army shake x Tele Mondaria enThen plot the data on a liner plads theNote: The respondents to the firwinz coseAueberry CheesecakeD-ChorwayRed velvet CheesecakeEUMCOreo CheesecakeEBE.DDBEEBD DBACDDAAADB31AATally no 1-5) 5 pointsA Blueberry CheesecakeRed velvet CheesecakeCOreo CheesecakeDChocolate Strawberry- Ube MacapunoLine Graph: (no. 6-10) 5 At the start of the war, which countries were on the side of the Central Powers? Check all that apply.C Ottoman EmpireO Great Britain0 RussiaD Austria-HungaryD Italy conflictos dentro de la obra de macbeth de william shakespeare? What does Faraday's law of induction states? To find the equation of a line, we need the slope of the line and a point on the line. Since we are requested to find the equation of the tangent line at the point (36, 6), we know that (36, 6) is a point on the line. So we just need to find its slope. The slope of a tangent line to f(x) at x Algum me ajuda? No tem a ver com escola dessa vez. Eu estou a muito tempo procurando um livro, no qual algumas pessoas receberam um bilhete para ir a uma biblioteca, porm eles descobrem que esto presos nessa biblioteca e precisam resolver uma srie de mistrios para sair de l. Me ajudem por favor Which type of graphic organizer would best organize your notes On the topic of food allergies in children and teens Qu nombres reciben los tejidos que danorigen a los tejidos adultos de las plantas?a. Tejidos diferenciadosb. Tejidos indiferenciados (meristemos)c. Tejidos vegetales Show all work to solve 3x2 - 5x 2 = 0. A eukaryote is a cell with a nucleus and membrane-bound organelles.O TrueO False WHAT KIND OF TREATMENT DO MOST OF THE VILLAGERS PREFER? Melvin begins his retirement fund at age 30, depositing $1,000 per month until age 50. Cindy begins her retirement fund at age 20, depositing the same $1,000 per month amount until age 50. Both Melvin and Cindy earn 5 percent annual interest on their funds, and there are no tax considerations in this problem. Based on the provided information :____________a) and assuming they retire at age 50, Cindy will have less than 50 percent more than Melvin b) and assuming they retire at age 50. Cindy will have exactly 50 percent more than Melvin. c) and assuming they both retire at age 60. Cindy will have less than Melvin. d) the difference between the two will get larger with higher inflation e) and assuming they retire at age 50. Cindy will have over 50 percent more than Melvin. Activity plans, as opposed to lesson plans, are designed for ____ learning. holistic "bits and pieces" teacher-directed school-age children's Please help me i will give Brainly Christina cycles 2 kilometers during each trip to work. Write an equation that shows the relationship between the number of trips to work x and the total distance cycled y. . Use trigonometric expressions to build an equivalent trigonometric identity with the given expression: cos (x) cos3 (x) = ?A)cos (x) sin (x)B)cos (x) sin2 (x)C)sin2 (x)D)sin (x) cos2 (x)