Choose the true statements about amyloid fibrils. 3 options are correct:a) An amyloid fibril typically forms from aggregates of misfolded peptides resulting from frameshift mutations. b) An amyloid fibril is stabilized by hydrophobic interactions between aromatic residues. c) Soluble proteins that misfold and form amyloid fibrils become insoluble. d) Because most newly synthesized proteins fold correctly, the accumulation of misfolded proteins (or fragments) tends to occur slowly, thus explaining the slow onset of disease. e) Proteins that convert to an amyloid fibril structure tend to have low solubility in their native form.

Answers

Answer 1

Answer:

The correct answers are: b) "An amyloid fibril is stabilized by hydrophobic interactions between aromatic residues", c) "Soluble proteins that misfold and form amyloid fibrils become insoluble", and d) "Because most newly synthesized proteins fold correctly, the accumulation of misfolded proteins (or fragments) tends to occur slowly, thus explaining the slow onset of disease".

Explanation:

Amyloid fibrils are protein aggregates that can cause pathological conditions, for instance, they are found in brain tissue in people with Alzheimer disease. This disease, and other relates diseases, have a slow onset because most newly synthesized proteins fold correctly and the protein aggregates are made up misfolded proteins. This newly synthesized proteins are soluble, but once the proteins are misfolded, they form amyloid fibrils that are insoluble. The amyloid fibrils are stabilized by hydrophobic interactions between aromatic residues, which are formed within the complex of insoluble misfolded proteins.


Related Questions

7. Compare and contrast the roles and structures of DNA
and RNA​

Answers

Answer: dna and rna have four nitrogenous three of which they share Cytosine, Adenine, and Guanine the differs between the rna has Uracil and the dna has thymine but dna is doubled  stranded and rna is single stranded

Thymine

Explanation:

What is the process responsible for gamete formation?

Answers

Answer: Formation of Gametes

Both the male and female gametes are formed during a process of cellular reproduction called meiosis. During meiosis, the DNA is only replicated or copied one time. However, the cells are divided into four separate cells.

Explanation:

What is the purpose of the cell cycle?

Answers

Answer:

The most basic function of the cell cycle is to duplicate accurately the vast amount of DNA in the chromosomes and then segregate the copies precisely into two genetically identical daughter cells. These processes define the two major phases of the cell cycle.

Explanation:

Calculate ​pH a decrease of one unit on the pH scale means a solution is ten times more acidic. a decrease of two units means the solution is 100 times more acidic. how much more acidic is acid precipitation( pH = 4.0) than pure water (PH= 7.0 )

Answers

Answer:

Each unit of decrease has an exponential increase. So if you are looking at an item that has a Ph of 4 and water has a Ph of 7 —-that means it is 10 to the 3rd power more acidic or 1000 times more acidic than water.

Explanation:

A decrease of one unit on the pH scale means a solution is ten times more acidic; a decrease of two units means the solution is 100 times more acidic; so pH 4 means the solution is thousands of times more acidic than normal water.

What is the effect of pH on the cell?

The pH scale shows the pH from 1 to 14, where pH 7 is taken as neutral, below which the solution is more acidic, and above which the solution is more basic. The pH has an important role in the organism as it regulates the blood and maintains enzymatic function.

Hence, a decrease of one unit on the pH scale means a solution is ten times more acidic; a decrease of two units means the solution is 100 times more acidic; so pH 4 means the solution is thousands of times more acidic than normal water.

Learn more about the pH here.

https://brainly.com/question/15289741

#SPJ6

How did Scientist find the human gene that makes insulin

Answers

Answer:

Recombinant DNA is a technology scientists developed that made it possible to insert a human gene into the genetic material of a common bacterium. This “recombinant” micro-organism could now produce the protein encoded by the human gene. Scientists build the human insulin gene in the laboratory.

Explanation:

What type of asteroid/meteorite do they believe brought some water to the Earth?

a. Stoney Iron
b. Iron
c. Steel
d. Carbonaceous Chondrite

Answers

The answer should be d

which statement best explains the difference the difference in growth among the plants

Answers

Answer:

Where are the statements

Which factors of earth postion would contribute to long term climate change?

Answers

Answer:

Strength of the sun. ...

Changes in the Earth's orbit. ...

Changes in the orientation of the Earth's axis of rotation. ...

Quantity of greenhouse gases in the atmosphere. ...

Carbon dioxide content of the oceans.

Explanation:

here is your answer i think this might be to advaiesds   for answer

please just say thanks

It allows radiation to seep through the ozone and lowers temperatures.
It causes temperatures to rise.
It reflects solar energy back into space and lowers temperatures.
It causes rainstorms.
It reflects solar energy back into space and lowers temperatures.

The image shows the femur bone of the leg and part of skull . Identify the various bone markings in the image

Answers

Answer: A fossa is a shadow depression in the bones of the skull. A firearm is a hole in a bone. In the image of the skull, the hole at the base is the opening through which the spinal cord passes. A tubercle is a small nodualr projection, which is visible in the image of the femur bone of the leg.

Explanation: Edmentum

What part of the fungus is seen in the woods or on the lawn? Please help I will mark you the branniest!

Answers

Damp conditions can bring out other types of fungi that can create more serious problems for your lawn. Brown patch, fusarium blight, and rust are a few of the diseases that thrive in wet grass.

Polypores are also called bracket fungi, and their woody fruiting bodies are called conks. Most polypores inhabit tree trunks or branches consuming the wood, but some soil-inhabiting species form mycorrhiza with trees. Polypores and their relatives corticioid fungi are the most important agents of wood decay.

please mark as brainliest

fhelp me plzzzzzzzzzzz

Answers

Answer:

B

Explanation:

The answer would be oxides

I need help please and thank you

Answers

Answer:

i think its C.population density

Explanation:

biomass shows how much biomass (the amount of living or organic matter present in an organism) is present in the organisms

Answer:

A biomass pyramid shows the population density at each trophic level

Decomposers act in which level of the trophies pyramid?

Answers

They are the “last trophic level” in some hierarchies because they feed on everything (National Geographic). However, according to the strict trophic level definition they would be primary consumers

Answer:

Decomposeds act on the last trophie level.

Explanation:

A separate trophic level, the decomposers or transformers, consists of organisms such as bacteria and fungi that break down dead organisms and waste materials into nutrients usable by the producers.

What is the runoff pollution, and what causes it?

Answers

Answer:

Polluted agricultural runoff is a major source of water pollution globally. Agricultural runoff is primarily caused by melted snow or rainfall. It is, in essence, water that does not stay in the soil but instead flows on the surface and carries a variety of polluting elements.

Explanation:

The lovely people at google

When you smile, you have dimples is this a gen or a jene

Answers

Answer:

It's a gen.

Explanation:

The ______________ system consists of the hypothalamus, pituitary, amygdala and hippocampus. They are located in the brain just under the cerebrum.
A) endocrine
B) limbic
C) nervous
D) skeletal

Answers

Answer:

The answer is B or limbic.

Explanation:

"The amygdala is the emotion center of the brain, while the hippocampus plays an essential role in the formation of new memories about past experiences."

Answer: LIMBIC  

Explanation: I JUST DID IT.

Normal cells die in a nutrient medium containing thymidine and methotrexate, whereas mutant cells defective in thymidylate synthase survive and grow. The mutant cells grow because the medium contains the___________ they are unable to make normal cells, however, continue to synthesize their own and thereby convert their limited supply of to________ . The methotrexate inhibits , so cannot be regenerated. Without a supply of___________ for the synthesis of nucleotides and amino acids, the cells die.

Answers

Answer:

*Thymidine

*THF to DHF

*THF

Explanation:

Normal cells die in a nutrient medium containing thymidine and methotrexate, whereas mutant cells defective in thymidylate synthase survive and grow. The mutant cells grow because the medium contains the_____Thymidine______ they are unable to make normal cells, however, continue to synthesize their own and thereby convert their limited supply of to__THF to DHF______ . The methotrexate inhibits , so cannot be regenerated. Without a supply of______THF_____ for the synthesis of nucleotides and amino acids, the cells die.

NOTE:

THF means Tetrahydrofolate

DHF means Dihydrofolate

Thymidine which is also reffered to as deoxythymidine, is described as a deoxynucleoside that is composed of the pyrimidine base thymine that is attached to the sugar deoxyribose. Thymidine is a nucleoside made up of pentose sugar, pyrimidine base tymine and deoxyribose, it is one of the the four nucleoside found in exclusively DNA as well as T-loop of tRNA.

Tetrahydrofolate also known as tetrahydrofolic acid can be described as part of folic acid that function as a coenzyme which aid metabolic reactions that includes nucleic acid and amino acids. It is also reffered to as one-carbon metabolism, and it's oone-carbon mechanism is associated to the histidine, serine of amino acid.

Which of these are included in the immune response? Select 3 correct answers. T-cells lymphocytes B-cells stem cells oil

Answers

T-cells cause they take part in the immune response

Answer:

A, B, C

Explanation:

state what scientists might do to successfully combat bacteria that are resistant to vancomycin​

Answers

Answer:

Probably make a new medicine.

Find a new chemical to combat the bacteria or they can genetically engineer new antibiotics

Incineration is a way to control pollution. which is an example of an incinerator

Answers

Answer: For example, hospitals and research facilities generally use incinerators to dispose of biological tissues, blood-contaminated materials, and other medical wastes such as disposable hypodermic needles and tubing.

Explanation:

Answer:

afterbuner

Explanation:

2. Name the vessels that arise from the aortic arch

Answers

Answer:

Three vessels come out of the aortic arch: the brachiocephalic artery, the left common carotid artery, and the left subclavian artery.

Explanation:

Hope this helps! <3

Question 2 (1 point)
The main goal of conservation biology is to

Answers

Answer:

(1) to investigate and describe the diversity of the living world; (2) to understand the effects of human activities on species, communities, and ecosystems ; and (3) to develop practical interdisciplinary approaches to protecting and restoring biological diversity.

Explanation:

To protect species from extinction, preserve their habitats and protect bio diversity.

what is the probability that an offspring will have SsRr genotype from a cross of SsRr individuals

Answers

Answer:

6.26%

Explanation:

Will change in ocean salinity cause a change in climate overall? Why or why not?

Answers

Answer:

Yes

Explanation:

Ocean play very important role in climate change. Change in the salinity of ocean definitely going to affect climate because changes in salinity have effect on water density.

Change in density allows changes in the movement of seawater and shift in climate pattern. if salinity will increase, water will become heavier and sink deep in ocean, which joins the currents that circulate all over the world. These currents affects the transport of heat and affect the rainfall pattern, example of such currents is gulf stream.

So, stable salt densities or salinity in the oceans keep the earth’s climate in balance.

CRAZY REWARD FOR ANSWER AND 5 STARS FOR EVERY ANSWER



The apple tree receives 1000kJ of light from the Sun, but only uses 500kJ. Of this, only 250kJ are stored in the tree to be transferred through the food chain.

a)Calculate the efficiency of the tree (2)

b)State the ways in which the remaining energy has been transferred out the of the food chain (3)

Answers

a) [tex]\frac{250}{1000}[/tex] × [tex]100[/tex] [tex]= 25[/tex]%

b) Respiration, decomposition

Which of the following are examples of an inherited trait for plants? (Check ALL correct answer.)

a) The type of fruit it makes
b) How tall it grows
c) If it receives enough rain
d) The color of its flowers

Answers

I am pretty sure the answers would be A and D but I’m not sure on B because a lot of factors feed into B but I would go with A and D.

Answer:

A,b,d

Explanation: These are traits

The carbon cycle is closely related to which of the following?

nitrogen cycle
movement of oxygen
rock cycle
water cycle

Answers

The water cycle
P h o t o s y n t h e s i s

Answer:

Actually, the correct answer is B. movement of oxygen.

Explanation:

Which phrases accurately describe this rock? Check all that apply.

1.formed underground
2.randomly arranged grains
3.formed through sedimentation
4.formed by extreme heat and pressure
5.layers that tend to split apart along bands

Answers

Explanation:

4. formed by extreme heat and pressure

1. formed underground

Answer: Formed underground

Formed by extreme heat and pressure

Explanation:



Yersinia pestis, the organism that causes the bubonic plague, led to the deaths of approximately 75 million people is the 1300's. This was known as the Black Death. Which type of organism caused the bubonic plague?

Answers

Answer:

Yersinia pests

Explanation:

it is  a bacterium. its vectors is infected flea from an animal.  The plague  can also results from contact with contaminated fluid from dead infected animal   from bubonic plague.

when the flea bites, the bacterium enters the blood stream and through the lymphatic systems it finds it way into the lymph nodes of the armpit and pubic region.

it localized in the nodes leading to swelling, enlarged nodes-buboe, with  painful sensation.

chills, high fever, seizures, are some of the symptoms.

proper hygiene is the best preventive methods.

Which resource is a non-renewable resources? A.fresh water B.Maple trees C.Solar Energy B.Precious metal

Answers

Answer:

Precious Metal, bc nature will not renew it and there's just a limited amount on any given planet.

Technically true for the sum of all water on the planet too, but fresh water gets renewed by cyclical processes in nature.

and solar energy (and trees for that matter) are also just renewed from our earthly perspective of space and time. stars do nuclear fusion, and this is a one-way process, single use basically.

so nothing is truly renewable, but we can't use up some things and get new supply for any given time, at least in time spans we can grasp.

(own work. would really, reallly appreciate the brainliest)

Other Questions
Is there a body part that doesnt have a lot of prosthetic options currently available? What market/users are currently underserved? All of the following statements about the standard normal probability distribution are true EXCEPT: a) the expected value is 0 b) the total area under the standard normal curve is 1 c) the standard deviation can assume any positive value d) the probability that z assumes values between -1 and 1 is 0.6826 Thomson Co. produces and distributes semiconductors for use by computer manufacturers. Thomson issued $800,000 of 10-year, 6% bonds on May 1 of the current year at face value, with interest payable on May 1 and November 1. The fiscal year of the company is the calendar year. May 1. Issued the bonds for cash at their face amount. Nov. 1. Paid the interest on the bonds. Dec. 31. Recorded accrued interest for two months. Journalize the entries to record the above selected transactions for the current year. If an amount box does not require an entry, leave it blank. May 1 Nov. 1 Dec. 31 A basket contains five apples and seven peaches. You randomly select one piece of fruit and eat it. Then you randomly select another piece of fruit. The first piece of fruit is an apple and the second piece is a peach. show work plz thanks!Theoretical Probability Compound Events How do limiting factors affect organisms in a community Howard is rock climbing. He descended 300 meters in 5 hours. Which is NOT equivalent to Howards average change in location per hour? A. 300/-5 meters per hour B. -300/5 meters per hour C. -(300/5) meters per hour D. -(-300/5 meters per hour In the box below, list how many, and which medications, were expired, and how you disposed of them.You can make stuff up for "list how many, which medications, were expired and how you disposed of them" Solve the inequality 3 x - 3 < 9 What are two reasons the Galapagos finches formed new species? 100 PTS PLEASE HELP PLEASEEE express your personal opinin about Saint Scholastica. Read the excerpts from personal letters and determine which excerpts show the writer's internal conflict.I'm not sure if you'll be happy to receive my letter,Rosalie and James have opposing views on dividing the property.I spent an hour debating if I should tell you about Tom's illness.I think you should give her a sapphire ring. She loves blue diamonds. Lyana is painting her bedroom. Her room is 12 x 18. The ceilings are 8 feet high. She will need to put two coats of paint on. How many cans of paint will she need if the square footage of one can is 400 square feet? Do you agree that effectiveness should win out over kindness as a leader? Explain your position.Please write 5 sentence responseThe best answer will be marked brainiest Explain the energy conversions that take place during combustion? how was waverlys relationship with her mom at the end of the story What is a key part of global trade today that allows for growth and diversity? Which of these shapes is a parallelogram but not a square?Select all that are true. Compute the investment account (market value differs from book value) Assume that the fair values of the investee's net assets approximated the recorded book values of the investee's net assets, except the fair value of receivables and inventories is $30,000 higher than book value, the fair value of land is $5,000 lower than book value, the fair value of property and equipment is $20,000 higher than book value and the fair value of liabilities is $7,000 lower than book value. In addition, the transaction resulted in goodwill in the amount of $25,000. What is the balance in the preconsolidation "investment in investee" account on the investor company's books on January 1, 2013, immediately after the acquisition of the investee company voting common stock? Not enough information provided $247,000 $170,000 $25,000 A lunch menu consists of 6 different sandwiches, 4 different soups, and 4 different drinks. How many choices are there for ordering a sandwich, a bowl of soup, and a drink?