You have performed exome sequencing and have identified a gene in which two different mutant forms are prevalent. Each mutation is a missense mutation, but they are found in different parts of the gene. What can you conclude about these mutations

Answers

Answer 1

Answer:

Missense mutations may have different effects

Explanation:

A missense mutation is a single base-pair nucleotide change that causes an amino acid substitution in the resulting protein chain. A missense mutation may have distinct effects depending on the amino acid that is replaced in the mutated protein. For example, it is expected that the substitution between similar amino acid residues (such as, for example, leucine and isoleucine) may have no effect, while the replacement of one amino acid with another amino acid with different properties/charges/functional groups may render the protein nonfunctional. Similarly, it is expected that missense mutations localized at different exons/gene regions render different functional effects on the resulting protein isoforms.


Related Questions

Which statements are true?
Check all that apply.


A is in Quadrant I.
B is on the x-axis.
C is in Quadrant I.
D is in Quadrant III.
E is on the x-axis.
F is on the x-axis.
G is on the y-axis.

Answers

Answer:

A, D, F and G

Explanation:

A, D, F and G

Answer:

A, D, F and G are the correct answers!

Hope this helps

Rita was all ears when Lee told her the secret. Lee knew that Rita would not spill the beans. Rita has always been a true friend and has a heart of gold. What did it mean by Rita was all ears?

Answers

Answer: Hi!

When the text says Rita was all ears, it meant that Rita was listening very closely to Lee and giving him all of her attention while he was talking.

Hope this helps!

she was really focus on wat he was talking bout

the most common source of osteomyelitis is an infection that migrates via the bloodstream. direct invasion from a fracture. surgical contamination. a joint prosthesis.

Answers

Answer:

The correct answer is ''an infection that migrates via the bloodstream.''

Explanation:

An infection is the invasion of pathogenic germs or microorganisms that reproduce and multiply in the body causing disease. Bones, like any other organ or tissue in the human body, can become infected. Osteomyelitis is a bone infection caused by bacteria, mainly Staphylococcus aureus, although in some cases it can also be caused by fungi. The infection can start in another part of the body and spread to the bone through the bloodstream. In this case, it usually occurs at the ends of the leg and arm bones in children and in the spinal column (vertebrae) in adults, especially the elderly.

Sodium and potassium ion channels have several negatively charged residues at the entry to the channel. Identify the bases on which K channels specifically select for K ions, in other words, why do K channels not enable Na ions to cross the membrane

Answers

Answer:

Mechanism in attachment.

Explanation:

K⁺ channels have narrow pores, which prevents the passage of larger ions. However, since Na⁺ has an ionic radius smaller than K⁺, this does not explain the selective permeability of these channels towards K⁺.

In this case, the channel pore has a narrow selective filter which is delimited by the backbone carbonyl oxygens (C=O). When a K⁺ ion enters in the selection filter it interacts with these oxygens, and the molecules of water bound to K⁺ are displaced, which allows the passage of the dehydrated ion K⁺ through the pore. However, a dehydrated Na⁺ is too small to interact with these carbonyl oxygens in the selective filter, which stays open. As a consequence, the Na⁺ ion remains bonded to the water molecules in a hydrated complex that is too big to pass through the channel.

How do living things differ from nonliving things?

Answers

Answer: living things such as “human beings”, “animals”, “plants”, and “microorganisms”.. Nonliving things do no exhibit any characteristics

Explanation: Nonliving things do not grow,respire, need energy, move, reproduce, evolve, or maintain homeostasis. They are made up of non living materials

Answer:

well essentially  living things

respire/breathreproduceeat and grow

we move, we respond to situations and we feel.

while non-living things

don't breathedon't reproducedon't eat or growand they don't feel or respond

examples of living things are humans, animals, plants and germs

and examples of non-living are plastic, water, buildings etc

Hope this helps (✿◠‿◠)

Birds belong to different species but share similar characteristics. What inference can be correctly drawn about this statement?

Answers

They all share common ancestors

In a nutrient medium that lacks histidine, a thin layer of agar containing around 10^9 Salmonella typhimurium histidine auxotroph produces around 13 colonies over a two day incubation period at 37 degrees centigrade. How do these colonies arise in the absence of histidine? The experiment is repeated in the presence of 0.4 micrograms of 2-aminoanthracene. The number of colonies the number of colonies produced over 2 days exceeds 10,000. What does this indicate about 2- anthracene? What can you surmise about its carcinogenicity?

Answers

0.4 micrograms of 3.0 equals 7.0


If a patient's disease has no known cause, the disease is referred to as

Answers

Then it is Untreatable

What type of imumity is present at birth?​

Answers

Answer:

Innate immunity

Explanation:

This is your body's first line of defense against germs when you are born. It includes physical barriers, such as skin and mucous membranes, and special cells and proteins that can recognize and kill germs.

Select the correct answer. Which of the following criteria can help Linda classify gases as greenhouse gases? A. gas molecules having three or more atoms B. gas molecules having a minimum of two molecules C. gas molecules having at least one oxygen atom D. gas molecules having at least one carbon atom

Answers

Answer:

A. gas molecules having three or more atoms

Explanation:

A greenhouse gas has the property to absorb infrared radiation and radiating it back to the earth surface.

A greenhouse gas must have three atoms or more, that will help the gas to absorb infrared radiation and restricts its way out of the atmosphere. some example of greenhouse gases are methane (CH4), carbon-dioxide (CO2) and nitrogen oxide (NO2).

Hence, the correct answer is "A".

Answer:

A//gas molecules having three or more atoms

Explanation:

100% on plato

The absorptive effectiveness of the small intestine is enhanced by increasing the surface area of the mucosal lining. Which of the following accomplish this task?

a. the rugae and haustra
b. plicae circulares, villi, and microvilli
c. the vast array of digestive enzymes
d. Brunner's glands and Peyer Patches

Answers

Answer:

Option B

The plicae circulares, villi, and microvilli

Explanation:

The plicae circulares are the folds of mucous membrane on the inside of the small intestine. They are covered with tiny hair-like structures called the villi, and microvilli. The purpose of those folds is to increase the surface area for the absorption of food nutrients to take place in the small intestine before the food finally moves on to the large intestine for excretion.

The tiny hair-like projections (villi, and microvilli) further increase the surface area available for nutrient absorption by providing extra surfaces in which the nutrients can diffuse into the small intestine through.

This makes option B correct.

What is the importance of blood group systems?? Please help ASAP

Answers

Answer:

The accurate grouping of blood is very important because when it comes to blood donation .if a blood is given to a patient that has a blood incompatible with the blood type of the blood that the patient receives, it can cause intravenous clumping in patients blood which can be fatal.

hope this helps you :)

Explanation:

Answer:

The ABO classification is the most important and relevant for blood compatibility. A small number of antigens and antibodies are responsible for the ABO blood types. The specific combination of these components determines an individual's type in most case

Explanation:

How many genetically different kinds of sperm could be produced by a Drosophila melanogaster male (XY)

Answers

Answer:

The correct answer is - 16 genetically different kinds of sperm could be produced by a Drosophila melanogaster male (XY).

Explanation:

There are four pairs of chromosome in Drosophila melanogaster. In this species homologous chromosomes pair and segregate but do not follow recombination or crossing over. Each chromosome has two alleles or copies so as we know there are four pairs of chromosomes, then total number of chromosome copies would be 8, then

number of different combinations = 2^n  (n = number of homologous pairs

)

2^n

= 2^4

= 16

Thus, the correct answer would be : 16.

Which plant represents the control group?

Answers

Answer:

The one without the fertilizer

Explanation:

Because it "isolates the independent variable's effects on the experiment and can help rule out alternative explanations of the experimental results"

1.) You decide to clean the bathroom. You notice that the shower is covered in a strange green slime. You decide to try to get rid of this slime by adding lemonade juice. You spray half of the shower with lemonade juice and spray the other half of the shower with water. After 3 days of “treatment”, there is no change in the appearance of the green slime on either side of the shower.

Independent Variable:
Dependent Variable:
Control:
Conclusion:


Answers

Answer:

The correct answer is :

Independent Variable:  side of the shower with lemon juice

Dependent Variable:  cleanliness of shower

Control:  spray of water

Conclusion: lemonade juice have no effect on slime

Explanation:

Independent variable in any experiment is the variable that is changed or manipulated as here side of the shower that is sprayed with lemonade juice is manipulated to see if there is any effect on the cleanliness of shower.

Dependent variable is the variable that is observed or measured to check if manipulated variable or independent variable have any effect on it, like the cleanliness is measured to check if lemonade juice clean the slime of the side or not.

The control is something that remains the same to check the condition or effect that is not changed or can be compared to it. Water spray is control in this case.

The conclusion of this experiment is that there is no effect of lemonade juice on the cleanliness of slime present in the shower

In any experiment, an independent variable is the variable that is altered or manipulated, such as the side of the shower that is sprayed with lemonade juice to determine if it has any influence just on cleanliness of the shower.

This dependent variable is a variable that can measure Lemonade a manipulated variable or independent variable has any effect on it, such as whether lemonade juice cleans the slime off of the side or not.

A control is something that remains unchanged to assess the condition or impact which has not changed or may be contrasted to it. In the this scenario, the water spray is under command.

The experiment concludes drinking lemonade seems to not influence the cleaning of slime inside the shower.

Each side of the shower with lemon juice is an independent variable.Shower cleanliness is a variable.A water spray can be used to keep things under control.In conclusion, lemonade juice does not affect slime.

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igneous rock can easily be identified through their​

Answers

Answer:

Explanation:

Igneous rocks can be identified by the determination of the composition and texture of the rock.

The organization of the cell and the organisms is maintained through the use of _______. A. Metabolism B. Responsiveness C. Energy D. Synthesis

Answers

Answer:

C. Energy

Explanation:

Marking as Brainliest

why is the chemical formula for disaccharides not two times that of the Monosaccharide.

Answers

Answer:

I DO

Explanation:

the gluteus maximus is located superior to which muscle

Answers

Answer:

piriformis muscle is below the gluteus maximus

The gluteus maximus is located superior to the gastrocnemius muscle.

The gluteus maximus is the most superficial gluteal muscle and the main extensor muscle of the hip. The group of the gluteal muscles includes the gluteus maximus, gluteus medius, gluteus minimus and tensor fasciae latae.  

The gluteus maximus is a thick muscle that has a quadrangular shape. It is responsible for the maintenance of keeping the upper body erect.

The gastrocnemius muscle, also known as leg triceps, is an important muscle that is required for walking and running. This muscle is located on the back portion of the lower leg.  

The tendon of the gastrocnemius muscle is joined with the tendon of the soleus muscle and both form the Achilles tendon and attach to the calcaneus (i.e., the heel bone).

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In a certain breed of plants, dark green is determined by the dominant gene 'G' and light green is determined by the recessive gene 'g'. The heterozygotes show 75% penetrance. If the parental cross GG x gg was made, how many of each of the expected phenotypes will be observed in a population of 400 F2 plants

Answers

Answer:

The answer is 300.

Explanation:

When we cross GG and gg, 100% of the offspring will be heterozygous. If the heterozygotes show 75% penetrance meaning that there is a 75% probability that the plant that has the G gene will actually show it in it's phenotype.

So that means that 75% of the offspring should have dark green color, which means that 300 plants will have the expected phenotype and 100 will not.

I hope this answer helps.

PLEASE HELP ME!!!! This figure shows two alleles for the beta-globin gene. The A allele is the most common allele. The S allele is responsible for Sickle Cell Disease. The R group glutamic acid is negatively charged, while the R group of valine is hydrophobic. What molecular change, ultimately resulting in the sickle cell phenotype, occurs when valine in substituted in place of glutamic acid at position 6 in the β subunit of hemoglobin?

Answers

Answer:

The correct answer is option B. The tertiary structure of the beta subunit changes, exposing a hydrophobic cleft which allows hemoglobin to form long chains in RBC.

Explanation:

As it is clearly mention as there is point mutation that leads to single nucleotide change which results in to valine instead of glutamate. Valine is hydrophobic in nature not like glutamate. Valine aggregate and makes a rigid structure of molecules.

Due to this rigid molecule of valine aggregates, RBCs form a crescent or sickle like shape due to the higher viscosity and low solubility of Mutated hemoglobin in deoxy condition. It leads to formation of polymer that blocks the vessels.

Thus, the correct answer is option B.

Gregor Mendel demonstrated that traits are passed from parents to offspring independently of one another under all circumstances that he tested. All other genetics researchers have observed this as well. Based on this information, the statement can be made that “traits are passed from parents to offspring independently of one another.” Which describes the statement of fact? a law a hypothesis a theory an observation

Answers

The answer is A. A law

Explanation:

The fact "traits are passed from parents to offspring" has been scientifically proven not only by Mendel but by many other scientists. Additionally, these experiments showed this phenomenon always occurs. In this context, this statement is considered a law, which is a statement that describes an event or phenomenon that always happens and has been proven through experiments. Moreover, this is classified as a law rather than a theory because it only describes a phenomenon of genetics but does not explain it.

Answer:

answer is (a) law

Explanation:

taking the test rn .-.

Lasix is a diuretic that blocks the reabsorption of sodium in the ascending loop of Henle. The result of giving this drug would be

Answers

Answer:

Reduced extracellular fluids within the kidney, reduced blood pressure.

Explanation:

The loop of henle, which are located within the nephrons in the kidney, have a task of acquiring the water and NaCl from the blood and keeping enough of it in the body so that the homeostasis is maintained.

The result of giving Lasix that reduces the amount of NaCl reabsorption would first of all be "reduced extracellular fluids within the kidney" and it would also change the pH level of the blood and drop blood pressure levels.

I hope this answer helps.

How do tiny atoms bond together to form bigger substances , and how are these substances important for life ?

Answers

Answer:

The detailed answer to this question is found in the explanation section.

Explanation:

Life is generally made up of matter, which is referred to as anything that has mass and occupies space. Matter is composed of elements such as carbon, hydrogen, oxygen etc, which in turn constitutes the smallest indivisible unit of an element called ATOMS.

Atoms are chemically bonded together to make up the elements in molecules and compounds. These compounds and substances are contained in the basic unit of life called CELLS, which play a pivotal part in the sustenance of life. For example, the enzymes and hormones that bring about physiological responses in our body are made up of protein molecules. These protein molecules are similarly composed of chemical elements such as carbon, oxygen, hydrogen, nitrogen etc, whose building blocks are atoms.

In a nutshell, all LIFE characteristics are made up of matter which possess atomic particles that are chemically bonded together to form substances that hold life together.

Which of the following statements is NOT true of
consumers?
A. They receive their energy indirectly from the
sun.
B. They are also called heterotrophs.
C. They are able to synthesize their own food.
D. They can sometimes eat other consumers.

Answers

C)

Explanation:

They are not able to synthesise their own food

The statement that is not true about the consumers is that they are able to synthesize their own food. The correct option is C.

Who is a consumer?

In biological terms, a consumer is an organism that consumes other plants and animals to get energy. They are after the producer in the food chain. They are unable to produce their own food.

Except for plants, all other organisms are consumers, they do not have chlorophyll present in their blood, to trap sunlight.

Thus, the correct option is C. They are able to synthesize their own food.

Learn more about consumers, here:

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Which of the following are correct regarding carbohydrates?

Answers

Answer:

Anomeric carbon comes from the corresponding aldehyde or ketone

Which fossil must form before the cast fossil can form?
amber
mold
frozen
petrified

Answers

Answer:

C

Hoped I helped

the leg of a dash are long and strong that keep their body away from the hot sand

Answers

My answer is an ostrich,a camel,and a fennec fox.

But the Fennec fox is the suitable answer...

The graph shows world fish production from both wild capture and aquaculture. What would happen if a genetically modified fish that grew rapidly to a large
size was introduced into aquaculture? Why?
A. Aquaculture will increase more rapidly due to the new fish’s rapid growth and economic value.

B. Aquaculture will increase more slowly due to the new fishes ability to outcompete wild fish.

C. Aquaculture will decrease more rapidly due to the new fishes ability to outcompetes wild fish.

D. Aquaculture will decrease more slowly due to the new fishes rapid growth and economic value.

Answers

Answer:

A. Aquaculture will increase more rapidly due to the new fish’s rapid growth and economic value.

Explanation:

The introduction of genetically modified fish would further promote the raising of fish in captivity.

This would also reduce the reliance on capture fisheries production.

More tones of fish would be produced yearly as a result of the rapid growth of the genetically modified fish, and therefore, this would lead to the rapid growth of Aquaculture.

Answer:

I believe the answer is A) Aquaculture will increase more rapidly due to the new fish's rapid growth and economic value.

Explanation:

I hope this helps you! Have a great day:)

Earth's Greatest Enemies?Climatologist James Lovelock(originator of theGaia_hypothesis ) once said that Earth's greatest enemies were cars, cows and chainsaws because of their contributions to destabilizing planetary climate.1. How do each of these things (cars, cows, andchainsaws) contribute to the destabilizing of Earth's atmosphere and climate? You must cite specificevidence from any Unit of the course to support your response. And...2. How are these three things connected to one another either by cause, effect or by solution. Consider all of the environmental concerns you have been learning about during the entire course and describe how these 3Cs as a group relate to one specific environmental issue (other than atmospheric destabilization).Reminder: Loss of land plants will not result in a reduction of atmospheric oxygen (because most of planetary photosynthesis and its resulting oxygen production is in the oceans).

Answers

Cars, cows and chainsaws are major polluters and their use must be regulated and limited, to reduce the emission of polluting gases into the atmosphere that can cause drastic climatic changes that harm the environment that we know intensely.

Although it is not widely publicized in the media and few people know about it, the chainsaw is a great villain of the earth's atmosphere, since its use releases large amounts of CO2 into the atmosphere, due to the burning of gasoline that these machines make to work. CO2, in addition to endangering the operator's life, is a gas that destroys the ozone layer and increases the effect of global warming. Not only does the chainsaw release this gas, but so do cars, which reinforces the need to use renewable fuels to be used in both cases.

Cows also release polluting gas, methane, which has a greater polluting potential than CO2. Methane is the result of the cow's digestive reactions, which release this gas into the atmosphere steadily. As herds of cows tend to be large, livestock becomes a major polluter, as herds result in a strong release of methane into the environment. This reinforces the need for increasingly stronger regulations for livestock, in addition to highlighting the importance of adopting alternative methods of feeding that reduce meat intake.

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