With age, somatic cells are thought to accumulate genomic "scars" as a result of the inaccurate repair of double-strand breaks by nonhomologous end-joining (NHEI). Estimates based on the frequency of breaks in primary human fibroblasts suggest that by age 70 each human somatic cell may carry some 2000 NHEl-induced mutations due to inaccurate repair. If these mutations were distributed randomly around the genome, how many genes would you expect to be affected? Would you expect cell function to be compromised?'vVhy or why not? (Assume that 2% of the genome-l.5% coding and 0'5% regulatory-is crucial information.)

Answers

Answer 1

Answer:

The size of the human genome is 3.3 * 10^9 bp, as mentioned the coding and regulatory sequences of DNA is 2 percent of the entire genome, that is, 3.3 * 10^9 bp * 2%, which will be equal to 6.6 * 10^7 bp.

Let us assume that there is equal distribution of the 2000 non-homologous end joining induced mutations. Thus, 1 NHEJ shall takes place after every 3.3 * 10^9 bp / 2000, which will be equal to 1.65 * 10^6 bp in genome.

Now, the number of NHEJ in the regulatory and coding region would be,

6.6 * 10^7 bp / 1.65 * 10^6 bp = 40

A maximum disruption of two genes, that is, one at each end can take place by each NHEJ. Thus, the number of genes getting affected by 40 NHEJ would be 80, that is, about 0.38 percent of the entire genes. About 21000 genes encodes protein in human genome.

Yes, the cell function would be compromised as there will be a loss of gene, and at the same time its products, that is, the regulatory RNAs and protein would drastically influence the activity of the cells.


Related Questions

How many deciliters are in 8.12 decaliters?
deciliters

Answers

Answer:

812

Explanation:

You just want to multiply it by 100.

Answer:

the answer to your promblem is 812

Please answer this...

Answers

Answer:

b, d

Explanation:

To be effective, key choices must be

Answers

Important, that connects to the text/story/magazine, includes key words, etc.

Draw a starch structure​

Answers

Explanation:

I miss not sure if it's right

Which is the largest group of mollusksWhich is the largest group of mollusks?

Answers

Answer:

gastropods

Explanation:

The largest group is the gastropods

Answer:

gastropods

Explanation:

why the bio remediation is a series of processes for wastes?

Answers

Answer:

It is a series of processes for waters because it break down organic substances in water so that it will not result or cause pollution when water is released into the environment.

Explanation:

Bio remediation is a natural process in which microorganisms is use to clean and treat contaminated water, soil and surface. This process ensure the growth of microorganisms that feed on the contaminants present in the such contaminated media. It can be use to kill oil souls and other contaminated media. It is use as series of process in water so as to break down organic substances or contaminants in water so that it will not cause pollution when the water is released.

briefly explain the mode of nutrition

Answers

Explanation:

There are 2 forms of nutrition/, autotrophic, and heterotrophic,

autotrophic= makes its food from raw materials,

heterotrophic= consumed nutrition, in mammals..

If a plant has a genotype Rr, what is the probability it will produce a gamete that’s is R?

A) 25%

B) 50%

C) 0%

D) 100%

Answers

Answer:

B 50percent I think

Explanation:

correct me if I'm not sure

If a plant has a genotype of Rr, then the probability that it will produce a gamete that is R is 50%, which is present in option B. 50% represents the R, and the remaining 50% represents the r.

What are the gametes?

The gametes are the products of the cells that undergo meiosis, and by the law of segregation, the alleles can segregate and the gametes are formed by the law of independent assortment. The alleles in this case are the R and r that are present on the chromosomes, and according to the segregation rule, half of the cells get the R allele and the other half get the r type of allele.

Hence, if a plant has a genotype of Rr, then the probability that it will produce a gamete that is R is 50%, which is present in option B. 50% represents the R, and the remaining 50% represents the r.

Learn more about the gametes here.

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An object is located 8 cm away from a convex lens. The image is 24 cm away from the lens on the other side. What is the focal length of the lens?
A. 4 cm
B. 6 cm
C. 16 cm
D. 32 cm

Answers

Answer: B. 6 cm

Explanation:

First we take down the information given to us,

distance from the lens to the image (v) = 24cm

distance from the original object to the lens (u) = 8cm

So using the formula

1/u + 1/v = 1/f

Where f is the focal length

So we just input our information

1/8 + 1/24 = 1/f

Therefore;

3/24 + 1/24 = 1/f

4/24 = 1/f

1/6 = 1/f

f = 6

Our focal length = 6cm

Answer:B.6

Explanation:

:)


26. The perimeter of a rectangle is 58cm. If the length is
18cm find it width.

Answers

Answer:

The width is 11cm

Answer:

11 is the width

Where are most of the nutrients from your food absorbed?

Answers

Hey there! Here’s you answer to your question:


People’s stomach acid helps to further digest to break down food and nutrients for example protein. But not much gets absorbed directly in the stomach, EXCEPT alcohol. The absorption of nutrients will mostly occur in the small intestine.
Please let me know if this helped :)

Huntington’s disease: Huntington’s disease is a disease in which certain parts of the brain waste away; symptoms usually begin later in life. In a community in Venezuela, an allele for Huntington’s disease (represented by the letter H) is completely dominantto the allele for no Huntington’s disease (represented by a lowercase h). The three possible parental genotypes are HH, Hh, and hh. There are six possible crossings that can be made between these genotypes (for example, HHxHH, HHxHh, etc.). Show the probabilitiesof the genotypesandphenotypesin the F1 generation from all sixpossible crossings.

Answers

Answer:

HH x HH, HH x Hh, HH x hh, Hh x Hh, Hh x hh, hh x hh.

Explanation:

In a community in Venezuela, an allele for Huntington’s disease (represented by the letter H) is completely dominant to the allele for no Huntington’s disease (represented by a lowercase h).

The three possible parental genotypes are HH, Hh, and hh.

There are six possible crossings that can be made between these genotypes. These are HH x HH, HH x Hh, HH x hh, Hh x Hh, Hh x hh, hh x hh.

       HH x HH

Genotype: All HH

Phenotype: all express the huntington's disease (prob: 1)

      HH x Hh

Genotype: 1/2HH  1/2Hh

Phenotype: all express the huntington's disease (prob: 1)

     HH x hh

Genotype: All Hh

Phenotype: all express the huntington's disease (prob: 1)

    Hh x Hh

Genotype: 1/4HH, 1/2Hh, 1/4hh

Phenotype: 3/4 express the disease, and 1/4 do not express the disease

    Hh x hh

Genotype: 1/2Hh  1/2hh

Phenotype: 1/2 express the disease, and 1/2 do not express the disease.

   hh x hh.

Genotype: All hh

Phenotype: All do not express the huntington's disease (prob: 1)

What is green building?

Answers

Answer:

Green building refers to the application of processes that take place throughout a building's life-cycle including planning, designing, construction, maintenance, renovation.

Explanation:

Green building is also known as green construction or sustainable building. It refers to the application of processes that take place throughout a building's life-cycle including planning, designing, construction, maintenance, renovation. All of these processes are environmentally responsible and resource-efficient. Green building ensures efficient use of land, energy, water, and materials.

Answer:

It is the practice of maximizing the efficiency with which buildings and their sites use resources (energy, water, and materials).

It is the practice of minimizing building impacts on human health and the environment.

Green building is also known as sustainable or high-performance building.

Explanation:

Edu 2021

Question 25 of 34
1 Point
Which of the following describes the structure of nucleic acids?
A. Nucleic acids consist of carbon, hydrogen, and oxygen only.
B. Nucleic acids are formed when a glycerol molecule joins with
three fatty acids.
C. Nucleic acids are long chains of nucleotides.
D. Nucleic acids are made of long chains of sugar molecules.

Answers

The answer is C
Nucleus acids are long chains of nucleotides

i need help in biology both questions!!

Answers

Answer:

4. a) Monoculture

5. c) Fossil fuels

Explanation:

4. a) Mono culture is the practice of cultivating one crop on a given land. Completely opposite to multiple cropping.

5. c) Fossil fuels provide energy to industries as industries get energy from mining. Therefore fossil fuels is an logical answer.

A graph with a calibration curve, linear regression and extrapolation was drawn up from your lab results. What were the two types of data that were being compared on the graph? (In other words what was on the X and Y axis) What does this graph tell you about the water sample you collected?

Answers

Answer:

X is the concentration of the substance being measured and Y is the response from the instrument that is being used to measure

Explanation:

A calibration curve is the plot of known concentration of substances where x is the increasing known concentration and Y is the response, typically "absorption" taken from the instrument that is used for measuring. This curve is then used to find out the concentration of the unknown substance by using it's absorbance and comparing it with the calibration curve. For example:

Concentrations and absorbance readings are as follows

0.5mg/mL=10 nm

1.0mg/mL=15nm

1.5mg/mL=20nm

2.0mg/mL=25nm

This data is plotted on a calibration curve. Next we measure the unknown substance the absorption is 20nm. We can suggest that the concentration is 1.5 mg/mL. If there are readings that fall inbetwen values then the formulat to calculate the right concentration would be y = mx + b, where m is the slope and b is the y-intercept.

Linear regression uses the modification of the slope formula y= a + bx to best see how the data of the water samples would fit on the slope of the calibration curve. X is the independent variable , b is the slope of the line and a is the y-intercept.

Extrapolation would be the action of calculating data that are outside the calibration curve,  assuming the trend would continue.

which of the following is an example of mechanical weathering

Answers

Answer:

Examples of mechanical weathering include frost and salt wedging, unloading and exfoliation, water and wind abrasion, impacts and collisions, and biological actions. All of these processes break rocks into smaller pieces without changing the physical composition of the rock.

Explanation:

Mechanical weathering involves mechanical processes that break up a rock: for example, ice freezing and expanding in cracks in the rock; tree roots growing in similar cracks; expansion and contraction of rock in areas with high daytime and low nighttime temperatures; cracking of rocks in forest fires, and so forth.

As the amount of water vapor in the air increases,

Answers

Answer:

what's the full question

Answer:

it would be,  " relative humidity increases"

Assume that three loci, each with two alleles (A and a, B and b, C and c), determine the differences in height between two homozygous strains of a plant. These genes are additive and equal in their effects on plant height. One strain (aa bb cc) is 10 cm in height. The other strain (AA BB CC) is 22 cm in height. The two strains are crossed, and the resulting F1 are interbred to produce F2 progeny. Give the phenotypes and the expected proportions of the F2 progeny.

Answers

Explanation:

In the given question, the trihybrid cross has been provided for the height trait and it is provided that recessive alleles (aabbcc) contribute 10 cm whereas dominant allele (AABBCC) contribute 22cm.

The height contributed by each dominant allele (A+A+B+B+C+C)= 22cm

The height contributed by each recessive allele (a+a+b+b+c+c)= 10 cm

The dominant genotype is 12 cm taller than recessive genotype which indicates that dominant allele contributes 2 cm.

In trihybrid cross-64 genotype will be formed with these dominant allele based on which the height of the plant will be determined.

The genotype with dominant allele (Height) and F2 progeny are

0 (10cm) -  1/64

1 (12cm)-    6/64

2 (14cm)-   15/64

3 (16 cm)-  20/64

4 (18cm)-   15/64

5 (20 cm)-  6/64

6 (22 cm)-  1/64

Answer:

Given,

aabbcc = 10 cm

AABBCC = 22 cm

The genes are additive which means that each dominant allele will contribute to the overall height. The base minimum height is 10 cm (no dominant allele) and the maximum height is 22 cm (all six dominant alleles). Thus, six dominant alleles contribute 12 cm of height to the base height, which means that each dominant allele adds 2 cm of height.

When, aabbcc X AABBCC :

AaBbCc ( F1 )

When, AaBbCc X AaBbCc :

7 types of phenotype is possible. They are:

6 dominant alleles = 22 cm

5 dominant alleles = 20 cm

4 dominant alleles = 18 cm

3 dominant alleles = 16 cm

2 dominant alleles = 14 cm

1 dominant allele = 12 cm

0 dominant allele = 10 cm

They will be in the ratio = 1 : 6 : 15 : 20 : 15 : 6 : 1 as given by the ratio of additive effect governing three loci. The intermediate phenotype ( 16 cm ) will be maximum in number and the numbers will decrease as we move to the extremes.

Which atmospheric layer prevents meteroids from reaching earths surface

Answers

Answer: Mesosphere layer i believe

Explanation: i had to do an essay on this before but i forgot alot of it

Answer:

Mesosphere

Explanation:

The temperature drops in this layer to about -100 degrees Celsius. This is the coldest region of the atmosphere. This layer protects the earth from meteoroids.

The universe consists of many different galaxies, which, in turn, consist of many different solar systems. Each solar system has a central star around which planets orbit.

Earth, for example, is a planet that orbits the Sun in the Solar System. The Solar System is one of many that can be found in the Milky Way galaxy.

This example demonstrates that

Answers

Answer:

Earth and the sun are a part of the solar system

What is the name of the system of measurement used by most countries
around the world?

Answers

Answer:

The International System of Units

Explanation:

(SI, abbreviated from the French Système international (d'unités)) is the modern form of the metric system. It is the only system of measurement with an official status in nearly every country in the world.

What are two examples of decomposers that break down animal skin?

Answers

Answer:

A decomposer is an organism that breaks down organic materials from dead organisms to obtain energy. These organisms are basically living recycling plants. Fungi, worms, and bacteria are all types of decomposers.

Many organisms depend on the land as a food source. Seasons can affect the amount of food that is available to these organisms. How would a long, cold winter most likely affect a population of deer?

The deer population will decrease.
The deer population will increase.
The deer population will remain almost the same.
The deer population will rebound the next year.

Answers

The deer population decreasing will most likely affect a population of deer.

What is a Population?

This can be defined as the number of organisms in a given area over a period of time.

Winter season is characterized by unavailability of plants for grazing due to the harsh weather condition which will lead to starvation and a decrease in the deer population.

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A long, cold winter is likely to decrease the population of deer due to reduced food availability and increased stress and mortality rates.

Why cold winter affects deer population?

A long, cold winter is likely to have a negative effect on the population of deer. This is because during a long, cold winter, the availability of food for deer can become scarce, especially if the winter is severe and there is a lot of snow on the ground. The snow can make it difficult for deer to access their food sources, such as grasses and shrubs. This can lead to malnutrition and starvation in some individuals, which can cause a decline in the population.

Additionally, a long, cold winter can also affect the reproductive success of deer. If the winter is too harsh, it can cause stress and illness in pregnant does, leading to fewer fawns being born in the spring. This can also contribute to a decline in the deer population.

Learn more about population, here:

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Why do cats purr?///////////////

Answers

Answer:

Cats also purr when they are nervous or in pain, leading some experts to believe that this uniquely feline vocalization is actually a method of self-healing. A domestic cat's purr has a frequency of between 25 and 150 Hertz, which happens to be the frequency at which muscles and bones best grow and repair themselves.

Explanation:

Answer:

it is there defense mechanism

Explanation:

they purr because that is there defense mechanism. They also a way to keep calm i very stressful situations.

There are two species of freshwater shrimp that are introduced to a pond. The first species, Caridina cantonensis, is brightly colored with red and white stripes. The second species, Caridina multidentata, is more mottled drab in coloration. Fish have an easier time finding and eating Caridina cantonensis due to their bright colors. When each of these species reproduce they produce about 100 offspring, but only 30% Caridina cantonensis offspring survive to reproductive age, while 75% Caridina multidentata offspring survive to reproductive age.
A. In this situation what is natural selection selecting for?
B. In this situation what is natural selection selecting against?
C. How do you predict this population will evolve?
D. Identify how each of the listed conditions from the above scenario that influence natural selection. Population must have variation. Some variations are favorable More offspring are produced than survive Those that survive have favorable traits Differential reproductive success

Answers

Answer:

A. Colour of the freshwater shrimp

B. Predator fish problem

C. Based on the number of offsprings that has survived

D. Differential reproductive success

Explanation:

A. The freshwater shrimp species C. cantonensis is brightly coloured which is easy to find by fish whereas C. multidentata is mottled drab in colour which can hide in the environment. Therefore the natural selection will select for the mottled drab of the shrimp.

B. The mottled drab colour of the shrimp will be selected against the predator species which feeds on the shrimp population as the predator species can find the brightly coloured species easily but the mottled drab colour will not be found.

C. The population is evolving can be identified based on the number of population found in that area as 75% of C. multidentata species reach reproductive stage while only 30% of C. cantonensis reach the reproductive rate.

D. The condition will be known as Differential reproductive success.

Which statement best describes the limits of science?​

Answers

Answer:

Science cannot answer philosophical answers.

Answer:

No scientific theory can ever be proven true.

Physics has two tremendously good theories: Einstein’s Theory of Relativity, and Quantum Field Theory.

These have been around for about a century and no contradictions have shown them to be false.

And yet these theories contradict each other, so one or both will eventually be supplanted.

Explanation:

Science is based upon evidence. And no matter how much evidence you have for a theory, it is impossible to say it is true.

Thus, truth is beyond what science if capable of.

Two boats are operating near each other. One of these boats must take early and substantial action to keep well away from the other boat. Which is the boat that must take action?

Answers

Answer:

The boat is referred as the give way boat

Explanation:

The give way boat is the one who is meant to take any action and must take early and substantial action to keep well away from the other boat.while the other boat is meant to sail on the sea normally. This is used in the prevention of accidents on the sea as a result

Of the two boats trying to maneuver their way at the same time.

Tropomyosin is a rod-shaped protein with a mass of 70 kDa and a sedimentation coefficient of 2.6S. Hemoglobin is a spherical protein with a slightly smaller mass of 65 kDa, but a much higher sedimentation coefficient of 4.31S. Which property of tropomyosin accounts for its slow sedimentation?


a. high particle density
b. elongated shape
c. high mass
d. low partial specific volume
e. overall net charge

Answers

Answer:

Explanation:

m

How are the carbon, nitrogen, and oxygen cycles similar

Answers

Answer:

Well I'm not sure if my answer is correct though but in all these cycles it involves the replenishment of air in ecosystem depending on the organisms which use it.

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Leta is making strawberry almond salad for a party for every head of lettuce that she uses she adds 5 ounces of almonds and 10 strawberries if she uses 75 ounces of almonds how many heads of lettuce and how many strawberries does leta use The port of South Louisiana, located along miles of the Mississippi River between New Orleans and Baton Rouge, is the largest bulk cargo port in the world. The U.S. Army Corps of Engineers reports that the port handles a mean of million tons of cargo per week (USA Today, September). Assume that the number of tons of cargo handled per week is normally distributed with a standard deviation of million tons.A. What is the probability that the port handles less than 5 million tons of cargo per week?B. What is the probability that the port handles 3 or more million tons of cargo per week? C. What is the probability that the port handles between 3 million and 4 million tons of cargo per week? D. Assume that 85% of the time the port can handle the weekly cargo volume without extending operating hours. What is the number of tons of cargo per week that will require the port to extend its operating hours? Read the statement below. Then decide whether you agree or disagree with it. Be prepared to support your opinion with details from the speech. Here's your discussion prompt: The voting age in America should be changed from 18 to 16. Whats the correct answer for this? Read the excerpt from the Declaration of Independence. What can be learned about the role and function of the government from the quote? The government invented the self-evident truths. The people get their power from the government. The government secures the rights of the people. Angelika thought of a number N, multiplied it by 7 and added 9. Then she told the result Rto Lisa.aWrite a formula that will tell you the value of R for any value of N Need help with this pls!!(Show work pls) Drag the tiles to the boxes to form correct pairs. Not all tiles will be used.Match each pair of points A and B to point such that _ABC = 90.A(3, 3) and B(12, 6)C(6,52)A(-10, 5) and B(12, 16)C(16, -6)A(-8, 3) and B(12, 8)C(18,4)A(12, -14) and B(-16, 21)C(-11, 25)A(-12, -19) and B(20, 45)A(30, 20) and B(-20, -15) fifteen darts have landed on the dart board shown. each dart scores 3,5, or 7 points. in how many different ways can the fifteen darts score a total of 75 points The before-tax income for Ivanhoe Co. for 2020 was $104,000 and $81,200 for 2021. However, the accountant noted that the following errors had been made: 1. Sales for 2020 included amounts of $39,000 which had been received in cash during 2020, but for which the related products were delivered in 2021. Title did not pass to the purchaser until 2021. 2. The inventory on December 31, 2020, was understated by $9,400. 3. The bookkeeper in recording interest expense for both 2020 and 2021 on bonds payable made the following entry on an annual basis.Interest Expense 14,400 Cash 14,400 The bonds have a face value of $240,000 and pay a stated interest rate of 6%. They were issued at a discount of $16,000 on January 1, 2020, to yield an effective-interest rate of 7%. 4. Ordinary repairs to equipment had been erroneously charged to the Equipment account during 2020 and 20221. Repairs in the amount of $8,600 in 2021 and $9,300 in 2022 were so charged. The company applies a rate of 10% to the balance in the Equipment account at the end of the year in its determination of depreciation charges. Prepare a schedule showing the determination of corrected income before taxes for 2020 and 2021. I Need Help! Please. Most of us cook our food in an oven that requires wood, propane, or electricity. Solar ovens, on the other hand, only require the rays of the sun as an energy source. There are over 60 different types of solar ovens, but most operate according to the same basic principles. Solar cooking is a process that concentrates sunlight on a reflective surface, converts light to heat, and traps heat inside a container. The oven is placed in direct sunlight and left until the food inside is thoroughly cooked. Cooking time varies according to the type of solar oven, the amount of sunlight, and the quantity of food. Solar ovens are generally cheap to purchase and operate. A simple Internet search can provide many tips on making your own oven from household items. Although solar ovens provide a less fuel-intensive way to cook, they do have some disadvantages. They take longer to heat food than conventional ovens, and they do not work well on cloudy or rainy days. For a growing number of people, the advantages of cooking by the suns power far outweigh the minor disadvantages. Why not buy or make your own solar oven today?9Which of the following sentences from the passage best supports the idea that solar ovens are financially affordable?A. Cooking time varies according to the type of solar oven, the amount of sunlight, and the quantity of food.B. A simple Internet search can provide many tips on making your own oven from household items.C. Although solar ovens provide a less fuel-intensive way to cook, they do have some disadvantages.D. Most of us cook our food in an oven that requires wood, propane, or electricity.Will mark branliest if you have the best explanation. Jim and Krutika are marking exam papers. Each set takes Jim 50 minutes and Krutika 1 hour. Express the times Jim and Krutika take as a ratio.Give your answer in its simplest form. EASY !!!! Marcus just created a new folder specifically for his business records, so he would like to move last month's business transaction file into the folder. 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