Which of the following phases of drug product development may be improved as a result of equipment, regulatory, supply, or market demands? Stage 1, stage 2, stage 3 or stage 4?

Answers

Answer 1

Sage 3 phase of drug product development may be improved as a result of equipment, regulatory, supply, or market demands.

How can drug development process be improved?

If robust randomised trials are the first rather than the last phase in the process of discovering new, effective treatments and if randomization pervades testing at all levels, the drug development process could be significantly enhanced. More randomised trials are required, not less, for both humans and animals.

What are the primary phases of the development of drugs?

A pharmacokinetic (PK) process called Absorption, Distribution, Disposition, Metabolism, and Excretion (ADME) measures how the new drug impacts the body.Each effect in ADME is mathematically described. Investigations that are effective in preclinical trials and preliminary safety testing are known as proof of principle (PoP) studies.

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Answer 2

Answer:

stage 3

Explanation:


Related Questions


Single-celled organisms called______harmlessly or helpfully can be found in almost all environments and can inhabit the human body

Answers

Single called organisms are called unicellular organisms.

The chart shows the intake (consumption levels) of proteins in 14-18yr olds. For which proteins is there the greatest difference between the recommended intake and the actual intake?

What is a recommendation of a food that teenagers could eat more of to fix this difference?

Answers

A recommendation of food that teenagers could eat more of to fix this difference is nuts and seafood.

Adolescence is a crucial time for good nutrition. Teenagers should have enough nutrients to support their growth since their bodies are continually changing and expanding. Protein is essential for growth because it helps the body create and repair new cells and tissues. It is a crucial part of things like skin, muscle, bone, and hair.

Diet is the total amount of food a person consumes. It determines both the amount and the quality of meals. The amount of nutrients a food contains is what is referred to as its quality. Based on the chart provided It is crucial to remember that protein requirements may be satisfied by a balanced diet consisting of foods like lean meats, poultry, fish, beans, legumes, nuts, and seeds.

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How do you think non-GMO labeling would change consumers' choices at the grocery store? 100-200 words

Answers

Answer:

Studies have shown purchase decisions are driven by a number of factors.

Along with the primary drivers of sensory characteristics and price, many buyers consider ingredient lists, allergen warnings and nutritional information. However, research indicates conventional shoppers are more likely to be attached to specific brands; whereas consumers with a preference for organic products are not brand-loyal so much as they seek organic products in general.  Similarly, the customers who regularly buy organic brands are less inclined to research whether they are considered sustainable or ethical, perhaps believing the designation implies as much.

While it’s not possible to foresee the exact outcomes of GMO labeling, a reasonable prediction can be made from the current labeling efforts of several major food brands. Beginning in 2016, General Mills, Campbells and Mars, Inc., as well as Kelloggs, Frito-Lay and ConAgra began identifying products containing genetically modified ingredients. This was done in accordance with the Safe and Accurate Food Labeling Act of 2015 and involved labels with language such as “produced with genetic engineering,” “partially produced with genetic engineering” or “may be produced with genetic engineering.”

In an interview with The Organic and Non-GMO Report, General Mills’ media relations representative Bridget Christenson revealed zero impact to company sales, stating, “We haven’t noted any strong consumer response, and haven’t seen any impact on sales.”

Similarly, Thomas Hushen, a media representative at Campbell’s, echoed similar reactions, disclosing, “Regarding sales, there are a variety of factors that impact sales and we can’t attribute changes to any one thing. It (labeling) was a popular decision in the eyes of consumers and customers.”

Although product appearance and price point are believed to be the most significant drivers of consumer purchase decisions by American shoppers, a 2011 study by Elise Golan and Kuchler, economists at the U.S. Department of Agriculture, looked into the habits of consumers in countries already requiring labels to identify genetically modified products. In their study, the economists noted little to no impact, stating “labels are generally a weak policy tool for changing consumer consumption behavior,” because they “generally fail to get consumers’ attention.” Moreover, their research indicated most individuals make impulse-driven food purchases and rarely consult labels at all.

In Brazil, where a ‘transgenic’ symbol has been required on all GMO-containing foods since 2001, Golan and Kuchler found many consumers were actually drawn to the products bearing the symbol, particularly if they claimed to possess a nutritional advantage.

While it’s fair to presume the current interest in organic and natural foods will be a strong, positive driver for non-GMO labeled products, current studies indicate the average consumer is unlikely to note or be particularly concerned whether a product has been produced with genetically enhanced ingredients, likely electing instead to maintain loyalty to brands they already know and trust.

What about the organic or health-conscious consumer?

The Organic Trade Administration reports that U.S. sales of organic products increased 11% in 2017, representing more than $39 billion in overall purchases. Currently, it’s estimated that almost five percent of all U.S. food sales are comprised of organic products. On that note, it’s safe to assume those already inclined to read labels and evaluate nutritional information are most likely to recognize and respond to a GMO designation. Nonetheless, although GMO labeling will likely increase the perceived value and justify higher costs for non-GMO goods among health-conscious consumers, it is still just a small fraction of the population.

That fact, coupled with the known impacts of widespread, self-initiated labeling at companies like Campbell’s and General Mills, lead to the reasonable conclusion that GMO labeling won’t have a significant impact on the majority of consumer purchasing decisions. Likewise, the smaller segment of consumers concerned with nutritional data are likely to respond to the information based on their own pre-existing beliefs and values.

Explanation:

Sofie is a single mother of three and works two jobs to be able to provide for them.She sometimes jokes that being under stress is the lifestyle she knows. Which condition does chronic stress most her at risk for developing?

Answers

Sofie is at the most risk of developing Cardiovascular diseases due to stress.

What is the disease?

Sofie is at danger of acquiring a number of physical and mental health issues due to ongoing stress.

High blood pressure, heart disease, and other cardiovascular problems can all be influenced by ongoing stress. The body's stress response system being constantly activated can put strain on the cardiovascular system and raise the chance of heart-related problems developing.  All these could come as a result of stress.

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Did digestion affects the lives of each one of us?

Answers

Answer:

yes, The digestive system breaks down food into nutrients such as carbohydrates, fats and proteins. They can then be absorbed into the bloodstream so the body can use them for energy, growth and repair.

Explanation:

What does the immune system do?

Answers

Answer:

The immune system serves as the body's defense system. It defends the body from parasites, bacteria, and viruses. Thanks to the immune system when you get sick you have a defense from the disease instead of quickly succumbing to it.

Toxoplasma is a parasite that lives in the

rinds of fruit

flesh of animals

refrigerator

heads of poultry

Answers

Toxoplasma is a parasite that lives in the B) flesh of animals.

Toxoplasma is a parasitic protozoan called Toxoplasma gondii. It has a complex life cycle that involves multiple hosts, including mammals and birds. The primary host for Toxoplasma is the cat family (felids), where it can reproduce and complete its life cycle.

The parasite can infect a wide range of warm-blooded animals, including livestock, rodents, birds, and humans. It is commonly found in the muscle tissues and organs of infected animals, particularly in the flesh or meat. When these infected animals are consumed by other animals or humans, the Toxoplasma parasites can be transmitted to the new host.

Therefore, the correct answer is B) the flesh of animals.

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BCBS distinctive features don’t include

Answers

BCBS distinctive features don't include: D. Policies issued by other third-party payers  

With Blue Cross covering medical services and Blue Shield covering hospital services, the insurance firms Blue Cross and Blue Shield were established independently. In the US, a group of health insurance plans is known as "Blue Cross." In order to provide its members with lower prices for healthcare services, BCBS organizations establish agreements with healthcare providers.

Additionally, they might consent to promptly reimburse healthcare providers for any services they provide to their subscribers. Other third-party payer policies are not a distinguishing characteristic of BCBS. Instead than relying on policies published by other third-party payers, BCBS firms create their own policies.

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Complete Question:

BCBS distinctive features don't include:

A. Maintaining negotiated contracts with providers

B. Agreement to provide prompt claim payments

C. Tax relief for nonprofit status

D. Policies issued by other third-party payers  

No he logrado comenzarlo ayuda please ….

Answers

This is a short essay comparing the definitions of nursing according to Florence Nightingale, the World Health Organization, and the College of Nursing Professionals in Puerto Rico.

How to make an essay?

Introduction

Nursing is a profession that has been around for centuries. It is a profession that is dedicated to the care of others, and it is a profession that is constantly evolving. There are many different definitions of nursing, but three of the most well-known definitions are those of Florence Nightingale, the World Health Organization, and the College of Nursing Professionals in Puerto Rico.

Content

Florence Nightingale was a British nurse who is considered to be the founder of modern nursing. She defined nursing as "the act of using the environment as a therapeutic agent." This definition emphasizes the importance of the environment in healing, and it also emphasizes the importance of nurses in creating a healing environment.

The World Health Organization defines nursing as "a profession that is concerned with the promotion of health, the prevention of illness, and the care of ill, disabled, and dying people." This definition is broader than Nightingale's definition, and it emphasizes the importance of nurses in promoting health and preventing illness.

The College of Nursing Professionals in Puerto Rico defines nursing as "the art and science of caring for individuals, families, and communities." This definition is similar to the World Health Organization's definition, but it also emphasizes the importance of the art and science of nursing.

Conclusion

The definitions of nursing by Florence Nightingale, the World Health Organization, and the College of Nursing Professionals in Puerto Rico all emphasize the importance of nurses in caring for others. However, there are also some differences in the definitions. Nightingale's definition emphasizes the importance of the environment, while the World Health Organization's definition emphasizes the importance of promoting health and preventing illness. The College of Nursing Professionals in Puerto Rico's definition emphasizes the importance of the art and science of nursing.

Despite these differences, all three definitions of nursing share a common goal: to provide care for others. Nursing is a noble profession, and it is a profession that is essential to the health and well-being of individuals, families, and communities.

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If Jay has time for only one type of workout during the week, what would most fitness experts say would be the MOST beneficial type of workout for Jay to complete?
• A.
an aerobic workout
О в.
a strength training workout
O с.
a flexibility workout
• D. a core training workout

Answers

The correct answer is B
D. A core training workout

Knowing the resident and implementing person-centered care may lead to the identifcation of abuse.
True or False?

Answers

The statement "Knowing the resident and implementing person-centered care may lead to the identification of abuse" is true.

Knowing the resident and implementing person-centered care can indeed contribute to the identification of abuse. Person-centered care emphasizes understanding and meeting the unique needs, preferences, and values of the individual. When healthcare providers have a deep knowledge of the resident, they are more likely to detect any deviations from their baseline behavior or signs of distress that may indicate abuse. By building strong relationships and trust with the resident, caregivers can create an environment where residents feel comfortable reporting any incidents of abuse or mistreatment. Additionally, person-centered care promotes open communication, enabling residents to express their concerns or discomfort. By actively listening and observing, caregivers can pick up on subtle cues that may suggest abuse and take appropriate action to address and prevent further harm. Thus, person-centered care serves as a valuable tool in recognizing and addressing abuse in healthcare settings.

Therefore, the given statement is true.

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What happens if the parent changes their mind after they surrender and want their baby back?
They are screwed, there is nothing they can do
they have 28 days to petition for custody
that have 365 days to petition for custody

Answers

The correct statement  is they have 28 days to petition for custody.

What is the adoption law?

Adoption law is  described as the generic area of legal theory, policy making, legal practice and legal studies relating to law on adoption

Depending on the jurisdiction and the particular circumstances, there may be differences in the procedure and choices open to a parent who has given their child up for adoption but later changes their mind.

Between nations, and even between different states or provinces, there are variations in the laws governing adoption and parental rights.

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Joe hasn’t consumed an adequate amount of protein yet for the day which of the following would be the best choice for a snack ?
A French fries
B pretzels
C salted almonds
D non fat Greek yogurt

Answers

Answer:Non fat greek yogurt

Explanation:Got that protein boi

D, non fat Greek yogurt

The consent form was signed by the parents, and the patient was taken to the operating room. She was anesthetized, and the right frontotemporal region was prepped and draped. A burr hole, using a rounded tip, was made into the skull. Immediate evacuation and decompression resulted. The patient’s vitals were stable, and she was discharged to the neurosurgeon for evaluation of a craniotomy. need cpt code

Answers

Answer:

The CPT code for this procedure would be 61107 - Craniotomy for evacuation of hematoma (e.g., epidural, subdural, intracerebral), including control of hemorrhage, when performed.

PLEASE HELP

this is a assignment on football

Answers

The different football strategies for both the attacking and defensive phases are given below:

Strategy for attacking gameplay.

Our team plans to implement a well-rounded attack approach in order to create uncertainty for the opposing defense. We will commence with building a dominant ground attack, employing a combination of forceful rushes and deceptive maneuvers to take advantage of weaknesses in the opposing team's defense.

This will create opportunities for downfield passing through play-action. Our quarterback will prioritize making rapid and precise passes towards our accomplished receivers, capitalizing on their swiftness and dexterity.

We will integrate innovative deceptive maneuvers to unsettle the opposing protection. To keep the defense off balance, it will be crucial to maintain a quick pace and take advantage of any mismatches.

Strategy for playing defensively.

We aim to have a strong and intense defensive strategy that will cause significant interruptions to our opponent's game plan. Our strategy involves utilizing a combination of zone and man-to-man coverage techniques to perplex the opposing quarterback.

The main focus of our defensive line will be on creating pressure by utilizing various tactics, such as stunts and blitz packages, to disturb the quarterback's comfort zone.

Linebackers are tasked with restraining the opponent's rushing game and transitioning into defense coverage as needed. Our secondary's primary goal is to have close surveillance on the opponent's receivers, obstructing their every attempt at catches and inducing turnovers.

We will focus on prompt and effective communication to anticipate and neutralize the offensive tactics of the enemy. In general, our defensive strategy is focused on gaining control of the line of scrimmage and generating impactful plays that can shift the course of the game.


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Maintaining an older person's dignity and autonomy is important. Give 5 examples to illustrate this.

Answers

Listening Carefully. One of the most important action family members and caregivers can take in caring for elders is to listen to them carefully. ...
Affording Respect. ...
Understanding Values. ...
Relinquishing Independence.

Maintaining an older person's dignity and autonomy is important. Five examples of this include providing choices, respecting privacy, valuing life experiences, ensuring physical comfort and promoting independence.

Maintaining an older person's dignity and autonomy is important.

1. Providing them with choices and involving them in decision-making processes regarding their care and daily activities.

2. Respecting their privacy and personal boundaries.

3. Valuing their life experiences and encouraging their participation in social activities.

4. Ensuring their physical comfort and safety.

5. Promoting independence through assistive devices and technologies.

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Jonas and Zari are hanging out at the skatepark when Jonas mentions that his foster dad makes skateboards. Even though Jonas doesn’t offer any more details, what conclusion can Zari MOST safely reach about Jonas’s family situation?

A.
Jonas belongs to a nuclear family.

B.
Jonas has been adopted into a new family.

C.
Jonas does not have a biological father.

D.
Jonas does not live with both biological parents.

Answers

Correct answer is option C. Based on the information provided, Zari can MOST safely conclude that Jonas does not live with both biological parents.

The fact that Jonas mentions his "foster dad" suggests that he is currently living with a foster family or has been adopted into a new family, but it is not clear whether this is a permanent situation or a temporary one.

Additionally, there is no information provided that would suggest that Jonas does not have a biological father.

This is because Jonas mentioned a foster dad, which suggests that he is not living with his biological parents. However, it does not necessarily mean that he has been adopted into a new family or that he does not have a biological father.

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1 What effect does the aging process have on dietary guidelines?

Answers

ging affects dietary guidelines by increasing nutrient needs, decreasing caloric intake, and emphasizing food variety for optimal health.

As individuals age, the aging process impacts dietary guidelines in several ways.

First, the need for specific nutrients such as calcium, vitamin D, and fiber often increases to support bone health and digestive functions.

Secondly, older adults typically require fewer calories due to a slowing metabolism and decreased physical activity. This makes it essential to choose nutrient-dense foods that provide the necessary vitamins and minerals without excessive calories.

Lastly, maintaining a diverse and balanced diet becomes more crucial as age-related changes in taste, smell, and appetite can lead to inadequate nutrient intake if not properly addressed.

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According to FDA regulations, if a product claims to be "low fat," it means that each serving must contain

3g or fewer of total fat
5g or fewer of total fat
10g or fewer of total fat
20g or fewer of total fat

Answers

Answer:

3 grams.

Explanation:

Do our intestines contain germs?

Answers

No but not all germs are bad some bacteria is natural.

Question 4
The screening test for cervical cancer or precancerous lesions in women is called the…
test.

Answers

Answer:

Pap test

Explanation:

The Pap (Papanicolaou) Test

The Pap test is a procedure used to collect cells from the cervix so that they can be looked at in the lab to find cancer and pre-cancer.

NEED ANATOMY PROJECT IDEAS!!!!

Using interdisciplinary media (such as performance, visual arts, education, games, video, experiment or demonstration, etc.), students will create a project that reflects aspects of Anatomy & Physiology that interests them.

- You may work with a group of no more than 3 people. (You don't have to work with a group unless you want to. Choose your group members wisely if you work with a group!)

- This project should teach the class something new that expands the knowledge gained from class. For example, if you want to do a project on exercise, you MUST go beyond the structures involved (muscles and bones) because we talked extensively about that in class.

Answers

Note that the visual arts that depicts the human anatomy of (Muscles and Skeleton) is attached according.

How many muscles and bones does a human have?

The axial skeleton will consist of 80 bones, whereas the appendicular skeleton will consist of 126 bones. In terms of the number of muscles in the body, there is no agreement on how many muscles there are.

The number of muscles is believed to be between 600 and 840.

The muscles work together to produce the muscular system, which includes cardiac muscle, skeletal muscle, and smooth muscle. Myology is the study of muscles, and a Myologist is a specialist in this discipline.

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what we can write in short term outcome (Goal) for shingles disease? and
long term outcome (goal) for shingles disease?
domain clear (goal) for shingles disease?
goal influenced by bloom's taxonomy for shingles disease?

Answers

Short term out come; Reducing pain and discomfort associated with the shingles rash.

Long term goal; Preventing or minimizing the risk of recurrent shingles outbreaks.

Domain clear goal; Manage the symptoms and effects of shingles, including pain relief.

Goal influenced by bloom's taxonomy for shingles disease; Understanding the causes, symptoms, and risk factors associated with shingles.

What is Shingles disease?

A framework called Bloom's Taxonomy divides educational objectives into many cognitive tiers. Although it is most frequently employed in educational contexts, it can also be used to create objectives for the management of illnesses and healthcare.

It is possible to classify the shingles disease domain as "Health and Wellness." Promoting general health and managing shingles symptoms and effects, such as pain alleviation, avoiding complications, and enhancing quality of life, are the objectives within this category.

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Which of the following factors are advantages of running healthcare organizations as a business?
Private businesses may have more funding and more advanced equipment and facilities. Competition between healthcare providers reduces quality of patient care and increases prices.
Private businesses may be able to provide faster service.
The motivation to make a profit encourages businesses to research new cures and treatments.
Private businesses usually are unable to provide many treatment options.
Patients can choose healthcare providers they like and trust and whose approach they like.

Answers

The motivation to make a profit encourages businesses to research new cures and treatments.

Advantages of health care organizations

Businesses are motivated to develop novel treatments and cures by the need to make a profit. Private healthcare companies may spend in R&D to find novel treatments and cures that will benefit patients due to the profit motivation.

Thus the entire business of research and development in the privately owned health care firm would be aimed at the target of making profit.

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This details the responsibilities of Local Government Units (LGUs) in implementing systems for mandatory waste segregation and establishing waste management facilities:

Answers

Answer:

policies

Explanation:

making policy is like setting rules and guide lines that a business must follow


What do you find a little difficult about this field?

Answers

Mmm Be specific??????

Which is an example of a medication commonly prescribed for mental health disorder ?

Answers

Antidepressants, Antipsychotics, Benzodiazepines.

What term BEST describes the personality trait of a person who reacts quickly to situations and worries a lot?

A.
glass half full syndrome

B.
depression

C.
anxiety

D.
negative emotionality

Answers

According to the information, we can infet that the term that best describes the personality trait of a person who reacts quickly to situations and worries a lot is "anxiety" (C).

What is anxiety?

Anxiety is a psychological condition that involves heightened levels of fear and apprehension. characterized by excessive and persistent worrying, restlessness and a tendency to react quickly to perceived threats or dangers.

Additionally, we can infer that:

Option A "Glass half full syndrome" refers to a positive outlook despite challenges, so it does not accurately describe the given trait.Option B "Depression" is a mood disorder characterized by persistent feelings of sadness and lack of interest, which is different from the described trait.Option D "Negative emotionality" (D) refers to a broader personality trait associated with experiencing negative emotions more frequently, but it does not specifically capture the quick reaction and worry aspects mentioned.

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With plenty of data stored on computer systems, data should not be a problem, but access to the data and sharing of information may have implications under federal regulations

Answers

The precautions that might be suggested are encryption, data backup and proper access controls.

To preserve patient privacy and adhere to federal standards, care must be taken while processing healthcare data. Make sure that only authorised staff have access to healthcare data. Using password-protected accounts, multi-factor authentication, and other access control methods ensure that only those who need access to specific data may do so.

When storing or sending healthcare data across networks, use encryption to keep it safe. This might aid in limiting unauthorised access to or publication of patient data. Healthcare data must also be periodically backed up and strategies must be in place to recover data in the case of a system emergency or breakdown.

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Complete Question:

With plenty of data stored on computer systems, data should not be a problem, but access to the data and sharing of information may have implications under federal regulations. What precautions might be suggested when handling health care data?

How to change negative habits

Answers

To change a negative habit you have to create a plan and work with the plan.

Changing negative habits

Determine the bad habit you want to change first. Be straightforward and concise when describing the habit you want to get rid of.  Consider your motivations for your habit. What initiates the behavior? What benefits does the habit provide for you? You can create tactics to break the habit by having a clear understanding of it.

Create a plan to change the habit once you have understood it. Goals in the plan should be clear and doable. It should also contain techniques for overcoming any potential difficulties.

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Who became very famous because of the Spanish war WILL MARK BRAINLIST JUST HELP ME ASAPRead the lines from "My Father is a Simple Man."and tells me the orangehas seeds and so is perpetual;and we too will come backlike the orange trees.How does the word choice in the lines convey the speaker's father's view on life?He feels that a life worth living is one spent in nature.He believes that a good life starts with good nutrition.He knows that life is a cycle of death and rebirth. He thinks one should search for the simple things in life. how do i answer this question? b.cups of water fill14Identical water bottles. How many cups fill each bottle? (3y + 4) (9y - 12y + 16)= pls answer and give the solution 22. Write the command forms of the verbs in the following sentences. *Be careful there are two irregular ones!1. Hacer la cama ___________________2. Sacar la basura ________________3. Poner la mesa ________________4. Limpiar el bao __________________ Which of the following is the densest compositional layer of the earth/A The inner coreB The outer coreC The coreD The crust Communication is ?A: the ability to share information effectivelyB: the ability to express thoughts and feelings clearly C: all of the above D: an important skill for achieving your goal Since the speed of light, c, is 0.3% slower in air than it is in outer space, how does that affect the observed wavelengths? 1What can you infer about the campaign slogan, "Four MoreYears?"It's for a Democratic candidateBI's relevant only during state primariesCIt's supporting the current PresidentD it can be used by either nominee Which of the following was not a cause of the Civil War? *SectionalismSlaveryState's RightsNativism Click an item in the list or group of pictures at the bottom of the problem and, holding the button down, drag it into the correct position in the answer box. Release your mouse button when the item is place. If you change your mind, drag the item to the trashcan. Click the trashcan to clear all your answers. Simplify the expression. Use the variables, numbers, and symbols that are shown. Drag them to the appropriate box in the polynomial. Use standard polynomial format. x(2x - 3) + (x - 3)(x - 4) Em cada caixote cabem 30 dzias de laranjas. Um caminho est carregado com 80 caixotes de laranjas. Quantas laranjas, no total o caminho est carregando? What are CD4 cells?a. T-cells that have a CD4 receptorb. B-cells that have a glycoprotein receptorc. HIV antigensd. red blood cells Listen, read the question, and choose the option with the correct answer, based on the audio.The video link ishttps://cdnapisec.kaltura.com/p/2061901/sp/206190100/embedIframeJs/uiconf_id/36511471/partner_id/2061901?iframeembed=true&playerId=Kaltura_1&entry_id=0_fhl0acujA Claudia le gusta ________.nadarnavegar por internetpintarpasar el rato sola what is the most important law after starting a business In April, a firm had an ending cash balance of $35,000. In May, the firm had total cash receipts of $40,000 and total cash disbursements of $50,000. The minimum cash balance required by the firm is $25,000. At the end of May, the firm had HELPP I NEED THIS BY 2:30The second angle of a triangle is 7 more than twice the first angle. The third angle is 3 less than the first. Find allthree angles if the sum of their angles is equal to 180. (Let x = the measure of the first angle) AYUDENME PORFAVOR!!! Could you help me please ?