what are two cell types that secrete histamine, heparin, leukotrienes and kinins, thus inducing the inflammatory response?

Answers

Answer 1

Mast Cells and basophils are the two types of cells which are responsible for the secretion of heparin, histamine, leukotrienes and kinins and therefore inducing the inflammatory response.

Mast cells are a type of immune cell which happen to release histamine as well as other hormones in response to a certain stimuli. Mast cells can be found in a number of places throughout the body but they especially abundant in the skin, lung airways, as well as the digestive tract.

Basophils are basically a type of white blood cell which work with our immune system to help defend our body against allergens, pathogens as well as parasites. Mast cells and basophils release heparin, histamine, leukotrienes and kinins upon degranulation and help induce immune response in our body.

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1. what is the nernst (equilibrium) potential of a monovalent cation ( valence) at 37oc given the intracellular ion concentration is 10 mm and the extracellular ion concentration is 80 mm?

Answers

The Nernst potential of a monovalent cation with a valence of +1 at 37°C, given the intracellular ion concentration of 10 mM and the extracellular ion concentration of 80 mM, is -62.9 mV.

The Nernst (equilibrium) potential is a measure of the electrical potential difference across a biological membrane that exists when a concentration gradient of ions is present. It can be calculated using the Nernst equation:

E = [tex]61 mV \times log(\frac{ [ion]out }{ [ion]in})[/tex]

Where E is the Nernst potential, [ion]out is the extracellular ion concentration, and [ion]in is the intracellular ion concentration.

Given the intracellular ion concentration of 10 mM and the extracellular ion concentration of 80 mM at 37°C, the Nernst potential can be calculated as:

E = [tex]61 mV \times log(\frac{80 mM}{10 mM})[/tex]

= -62.9 mV

This means that the electrical potential difference across the membrane is favoring the movement of the monovalent cation from the extracellular space to the intracellular space, in order to equalize the concentration gradient and establish an electroneutral state.

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some antibiotics control bacterial infections by attacking the ribosomes of the bacteria. why don't these antibiotics also harm the cells of human patients? [select all that apply.]

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The antibiotics do not harm the human cells because: (2) Human cells do not have the same ribosomes as the bacterial cells; (4) Human cell membranes prevent antibiotics from entering the cells.

Antibiotics are the chemical agents that prevent or slow down the growth of living organism inside the living body. Antibiotics can only harm the bacterial cell walls because they are made up of such components. Thus, the human cells can prevent the antibiotic entry.

Ribosomes are the components of cells involved in synthesis of proteins. These can be of two types: 70S and 80S. The ribosomes are found in both prokaryotic as well as eukaryotic cells. Ribosomes are composed of proteins and RNA.

The given question is incomplete, the complete question is:

Some antibiotics control bacterial infections by attacking the ribosomes of the bacteria. Why don't these antibiotics also harm the cells of human patients? [select all that apply.]

Human cells lack ribosome.Human cells do not have the same ribosomes as the bacterial cells. Ribosomes in human cells are attached to ER that provides protection. Human cell membranes prevent antibiotics from entering the cells.The acidity of human stomach breaks the antibiotic before it can harm the cells.

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which organs are involved in making calcitriol, the active form of vitamin d?

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The organs that are involved in making calcitriol which is the active form of vitamin D may include the liver, kidney, and skin.

What do you mean by Organ?

An organ may be defined as the collection of tissues that significantly make up a part of the body and performs a specific function in order to facilitate the survival of an organism. Examples of organs may include the liver, kidney, heart, etc.

Calcitriol is also known as the active form of vitamin D. It normally forms in the kidney. It is also known as 1,25-dihydroxycholecalciferol. It is a hormone that considerably binds to and activates the receptors of vitamin D in the nucleus of the cell.

The liver and kidneys convert vitamin D which is produced in the skin and taken up in the diet into the active hormone, which is called calcitriol.

Therefore, The organs that are involved in making calcitriol which is the active form of vitamin D may include the liver, kidney, and skin.

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please helps FAST will give brainlyEst, 5 stars, and thanks <3 :)
Response Template
This template will help you write about your perspective on the issue you chose.
My chosen issue: increasing spending on programs for those in need

Paragraph 1—Explain your perspective on the issue you chose. Write in complete sentences.

Paragraph 2—Describe a different perspective on this issue, one that differs from your own. Write in complete sentences.

Answers

I believe that there has to be increased spending on those programs meant for those in need. My take on this is below.

increasing spending on programs for those in need

Paragraph 1:

As a person who strongly values equality and fairness, I believe that increasing spending on programs for those in need is a crucial step towards creating a more just society. I believe that all individuals should have access to basic necessities such as food, shelter, and healthcare, regardless of their financial situation. I believe that the government has a responsibility to provide support for those who are struggling and to invest in programs that can help lift people out of poverty and provide them with opportunities to succeed. Furthermore, I believe that investing in these programs is not only the right thing to do from a moral standpoint, but it will also benefit society as a whole by reducing crime and improving public health.

Paragraph 2:

However, there are those who take a different perspective on this issue. Some argue that increasing spending on programs for those in need is not sustainable and that it creates a culture of dependence, where individuals become reliant on government support and lose the motivation to improve their own lives. They believe that programs like these do not address the root causes of poverty and can lead to an increase in government debt. They believe that the money would be better spent on programs that promote self-sufficiency and personal responsibility, such as job training programs and educational opportunities. These individuals believe that while helping those in need is important, it should be done in a way that empowers individuals to become self-sufficient, rather than creating a cycle of dependence.

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after the dna duplicates, how many chromatids are present in the nucleus?

Answers

After replication there are a total of 92 sister chromatids in each cell. There are 46 individual chromosomes in each cell.

if 1 inch=2.54 centimeters, how many inches are in 4.5meters?

Answers

Answer:

4.5 meters = 450 centimeters

450/2.54 = 177. 2 inches

What does the process of translation require?

Answers

Answer:

In addition to the mRNA template, many molecules and macromolecules contribute to the process of translation. Translation requires the input of an mRNA template, ribosomes, tRNAs, and various enzymatic factors.

Explanation:

13) A hawk dives toward a snake. When the
hawk is at a height of 200 feet the snake
sees the hawk, which is diving at 105 ft/s.
Estimate the time the snake has to escape.

Answers

A hawk dives toward a snake. When the hawk is at a height of 200 feet the snake sees the hawk, which is diving at 105 ft/s. The snake has to escape in 1.54 sec.

What is Snake?

Any of the more than 3,400 species of reptiles in the suborder Serpentes known as snakes, often known as serpents, are differentiated by their lack of limbs and highly elongated bodies and tails. Snakes are grouped with lizards in the order Squamata and are an example of a lizard that has undergone structural reduction, simplicity, and loss along with specialisation during the course of evolution. However, not all legless reptiles are snakes, and not all snakes lack external limbs.

h= -16t² + vt + s

-16t²-105t+200=0

a=-16,b=-105 and c=200

Solving this quadratic equation using quadratic formula we get

t= (105+154.35)/-32 or (105-154.35)/-32

But t cannot be negative

Hence t=(105-154.35)/-32= 1.54 seconds

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Earth's atmosphere is opaque to most types of radiation. Which type of telescope would
you never send to space? Explain vour reasoning

Answers

Answer:

The Earth's atmosphere blocks much of the light in the microwave band, so astronomers use satellite-based telescopes to observe cosmic microwaves.

Explanation:

A cell is short of water. Outline how osmosis will help the cell to gain water.

Answers

Answer:

When a cell is under a body region with more water than ions (solution), the water molecules move from that body region to the cell cytoplasm through the cell membrane. This makes a cell highly concentrated in water than ions.

Explanation:

[tex]{}[/tex]

In such case, the water molecules move from outside to inside of the cell through cell membrane (semi-permeable membrane). This process is called as endosmosis by which cell gain water.

Question
Which series of words describes lengths of geologic time from longest to shortest?

Responses

period, eon, era

period, eon, era,

era, eon, period

era, eon, period,

era, period, eon

era, period, eon,

eon, era, period

eon, era, period,

Answers

Answer:

Econ, Era, Period

Explanation:

The scientists study fossils and rock layers to find major changes. Series of words describes lengths of geologic time from longest to shortest is: eons, eras, periods, epochs, ages.

glycogen is stored mainly in which of the following tissues? a. muscle and liver b. pancreas and kidneys c. stomach and intestine d. brain and red blood cells

Answers

A) Muscle and the liver are the two tissues where glycogen is primarily stored.

Describe glycogen.

The form of glucose that is stored and composed of several linked glucose molecules is called glycogen. Your body's primary energy source is glucose (sugar). It originates from carbs, a macronutrient, which you eat in particular foods and beverages. When the glucose in the food you eat is not immediately needed by your body for energy, it is mostly stored as glycogen in your muscles and liver for future use.

Glycogenesis is the process through which your body converts glucose into glycogen. The process of glycogenolysis is how your body converts stored glycogen into energy. These two processes include a number of distinct enzymes.

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The transfer of genetic material from one bacterium to another through the mediation of a vector like virus is termed as:
A Transduction
B Conjugation
C Transformation
D Translation

Answers

Transduction is the word used to describe the transmission of genetic material from one bacterium to another with the aid of a virus-like vector.

Conjugation is a sort of gene transfer, right?

Through cell-to-cell contact with conjugative pili, a receiver bacterium acquires DNA from a donor bacterium in the process of conjugation. Certain plasmids or transposons mediate conjugation.

What varieties of vector gene transfer are there?

Vectors are simply vehicles made to transport beneficial genetic material, such a functional gene, into a cell. Adeno-associated virus, adenoviral, lentiviral, and retroviral are the four primary categories of viral vectors; each has special traits, applications, and restrictions.

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how did the covid-19 pandemic, affect the importation and exportation of goods to and from the caribbean islands?

Answers

COVID-19 pandemic has disrupted global trade, leading to reduced capacity and increased costs for Caribbean island imports and exports, affecting tourism and agriculture.

The Coronavirus pandemic has carried critical difficulties to the importation and exportation of products in the Caribbean islands. The pandemic has disturbed worldwide exchange and transportation organizations, prompting decreased limit and inflated costs for delivery merchandise. This has made it hard for Caribbean nations to get solid supplies of fundamental products, as a significant number of them vigorously rely upon imports. Also, travel limitations and boundary terminations forced by significant exchanging accomplices, for example, the US and Europe have frustrated the development of merchandise and made exchange more confounded. On the commodity side, the pandemic has hit ventures like the travel industry and horticulture hard, prompting lower interest for Caribbean merchandise and diminished income for these nations. These variables possess made it a difficult energy for the importation and exportation of merchandise to and from the Caribbean islands.

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describe the interior of a typical leaf. how do gasses move from the atmosphere to the chloroplast? (air space, mesophyll, stomata, diffusion)

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The interior of a typical leaf contains stomata and mesophyll cells that allow diffusion of various components with the air space.

Large voids in the leaf are filled with mesophyll cells, which also allow gases to diffuse. Gases from the mesophyll diffuse into and out of the air space through the stomata. A leaf's surface is covered in pores that are guarded by cells. A stoma is the collective name for this pair of structures (plural: stomata).

The little apertures known as stomata are found on the epidermis of leaves. Stomata are visible under a light microscope. Stomata can be found on the stems and other portions of various plants. Stomata are crucial in gaseous exchange and photosynthesis. Through opening and closing, they regulate the rate of transpiration.

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difference between epithelial and connective tissue is

Answers

Answer: The difference between Epithelial and connective tissues is that epithelial tissue forms a barrier around our body to keep external micro-organisms out of the body’s reach and covers most organs and cavities in the body whereas connective tissues are trained to sustain and attach to various body parts.

Explanation:

Select the correct answer.
How does the melting of ice caps near the North Pole affect the salinity of the ocean?
A.
Salinity decreases because freshwater flows into the ocean.
B.
Salinity increases because salt from the ice caps flows into the ocean.
C.
There is no change in the ocean’s salinity with this process.
D.
Salinity increases because of the stored pockets of air and salt.

Answers

The melting of ice caps near the North Pole affects the salinity of the ocean by  decreases because freshwater flows into the ocean which is therefore denoted as option A.

What is Salinity?

This is also known as saltiness and it is referred to as the amount of salt dissolved in a body of water, called saline water. It is usually measured in g/L or g/kg.

The melting ice causes freshwater to be added to the seawater in the Arctic Ocean which flows into the North Atlantic. The added freshwater makes the seawater less dense thereby decreasing the salinity in this scenario.

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Order the following features by the type of volcano they are associated with. a. pyroclastic flow B. Lava c. fiery fountain d.Strombolian eruptions e. side eruption F. pillow basalt g. felsic lava

Answers

The following characteristics are according to the type of volcano they are related to pyroclastic flow, lava stratovolcanoes, and Hawaiian volcanic eruptions associated with fiery fountains.

A volcano is a rupture in the coating of a terrestrial-mass object, in the way that Earth, admits new basalt, powder remains after a fire, and smoke to escape from a magma room beneath the surface. On Earth, volcanoes are usually raised places fundamental plates are diverging or gathering, and most are established undersea.

The molten rock (magma) in flood-basalt eruptions issued surely. This admitted vapor that was captured in it was expected released surely also. This volcano matter produces "fire-fountain" eruptions – a source of magma rising large groups of meters (large groups of yards) into the air.

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which is a nitrogenous waste that is transported in the plasma?

Answers

Answer:

urea

Explanation:

nitrogenous waste compounds such as urea are produced by the breakdown of various substances in the body which are then carried in the plasma to the kidneys to be excreted

What body system involved in the mechanical and chemical breakdown of food?

Answers

The body system involved in the mechanical and chemical breakdown of food is the digestive system.

The digestive system is responsible for breaking down food into smaller components that can be absorbed and utilized by the body's cells.

The mechanical breakdown of food begins in the mouth, where chewing and grinding with the teeth breaks down large pieces of food into smaller pieces. This process is called mastication.

The digestive system is also responsible for absorbing the products of digestion into the bloodstream, which carries the nutrients to cells throughout the body. This process occurs mainly in the small intestine, where the majority of nutrient absorption takes place. The remaining undigested material is eliminated from the body through the large intestine and rectum.

The digestive system plays a critical role in the breakdown and utilization of food, and any disruptions to this system can have significant impacts on overall health and wellness.

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which organelle would you expect to see a lot of in human stomach cells that secrete a lot of enzymes?

Answers

Lysosomes are membrane-enclosed organelles that contain a variety of enzymes that may degrade various forms of biological polymers, including proteins, nucleic acids, carbohydrates, and lipids.

What type of endoplasmic reticulum is most likely to be found in stomach cells?

Proteins generated in secretory cells are examples of proteins synthesised by the rough endoplasmic reticulum. These include digestive enzymes generated in the stomach and protein hormones produced in the pancreas such as insulin.

The mitochondria are home to the most enzymes. In eukaryotic cells, mitochondria contain respiratory enzymes involved in ATP generation. The inner mitochondrial membrane is densely packed with respiratory electron transport enzymes.

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explain homeostasis and negative feedback loop in regards to temperature in a human with an example of walking from the hot summer heat outside to a cold air conditioned room inside.

Answers

Negative feedback loops are frequently involved in homeostasis maintenance. The stimulus or cue that sets off these loops causes people to react negatively.

In homeostatic systems, such as thermoregulation, negative feedback loops are used in some processes (if body temperature changes, mechanisms are induced to restore normal levels) blood sugar control (insulin lowers blood glucose when levels are high ; glucagon raises blood glucose when levels are low).  The body has a negative feedback system that regulates body temperature. When the hypothalamus senses that the body is getting too hot, the body starts to perspire to try to bring the temperature back down to a healthy level.

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Topic: SARS-CoV-2

* What is this?
* what is virus?
* Why it is contagious?
* How to stop spreading the disease?
* What are the possible symptoms of the disease?
* How to prevent?
* Risk factors.
* Conclusion.

Answers

Answer:

SARS-CoV-2 is the virus that causes the disease COVID-19.

A virus is a microscopic infectious agent that can reproduce only inside the living cells of a host organism.

SARS-CoV-2 is contagious because it spreads from person to person through respiratory droplets generated when an infected person talks, coughs, or sneezes.

To stop the spread of the disease, it is recommended to practice good respiratory hygiene, such as covering your mouth and nose with a tissue when you cough or sneeze and throwing the tissue away immediately. Washing hands regularly with soap and water for at least 20 seconds is also crucial. Additionally, wearing a mask and practicing social distancing can help prevent the spread of the virus.

The symptoms of COVID-19 can vary from mild to severe and can include fever, cough, shortness of breath, body aches, loss of taste or smell, and more.

To prevent COVID-19, it is recommended to get vaccinated, follow the guidelines set by health authorities, and practice good hygiene such as regular hand washing and wearing masks in public settings.

Risk factors for COVID-19 include age, underlying health conditions, and exposure to crowded settings or close contact with infected individuals.

In conclusion, SARS-CoV-2 is a contagious virus that causes COVID-19 and can spread from person to person through respiratory droplets. To stop the spread of the disease, it is important to practice good hygiene and follow the guidelines set by health authorities. Additionally, getting vaccinated and being aware of risk factors can help prevent the spread of COVID-19.

Which hormone increases basal metabolic rate in the body?

Answers

Thyroid hermone is the correct answer

What are characteristics of a primary immune response?

Answers

Answer:

The primary immune response is characterized by the appearance of neutralizing antibodies of the IgM class between days 4 and 7, several days before detection of IgG antibodies.

Explanation:

Hopefully this is the answer you are looking for.

question 15. albinism in humans is autosomal and fully recessive to normal color. a couple, who are both normal, have a daughter who is albino and a son who is normal. 15a. the probability that their normal son is a carrier of the albinism gene is

Answers

The probability that a couple's normal son is a carrier of the albinism gene is 1/4.

Let the allele for albinism be addressed by a (since it is latent), the typical skin variety allele would then be A.

A typical individual would have either AA or Aa genotype. The Aa, despite the fact that ordinary in appearance is conveying the albinism allele and is known as a transporter of the characteristic.For an ordinary couple to have brought forth a child with albinism, it implies they are both a transporter of the characteristic (Aa).

Crossing the two people in marriage:

       Aa x Aa

  AA Aa Aa aa

The likelihood of bringing forth a albino is, subsequently, 1/4.These probabilities continue as before for each potential birth independent of the quantity of kids they as of now have.

Hence,albinism gene carrier probability is 1/4.

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(Complete question) is:

albinism in humans is autosomal and fully recessive to normal color. a couple, who are both normal, have a daughter who is albino and a son who is normal.,the probability that their normal son is a carrier of the albinism gene is

the relationship between fig trees and fig wasps is facultative. group of answer choices true false

Answers

the relationship between fig trees and fig wasps is facultative is true.

What connection exists between the fig tree and the fig wasp?

Mutualism is seen in the interaction between the fig tree and the wasp, which both deposits its eggs and pollinates the fig's flower. On the other hand, the fig permits the wasp's larva to feed on seeds in addition to shelter (fruit) for oviposition.

With their fig hosts, fig pollination wasps develop obligatory symbioses. About 75 million years ago, this mutualism first appeared. Female fig wasps fly considerable distances to transmit horizontally across hosts, in contrast to many other close symbioses that entail vertical transmission of symbionts to host progeny.

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what is the role of wildlife in the cultures and economies of alaska natives?

Answers

Wildlife plays a significant role in the cultures and economies of Alaska Natives.

For many Alaska Native communities, hunting and fishing are deeply ingrained cultural practices that provide sustenance and a connection to the land. Wildlife is also an important source of food security, providing a significant portion of the protein in the diets of many Alaska Native communities.

In addition to being a source of food, wildlife is also an important source of income for Alaska Natives. For example, the subsistence hunting and fishing industries provide a significant source of revenue for many Alaska Native communities, as do commercial fishing and hunting operations.

In terms of culture, wildlife is also seen as a spiritual and cultural resource for many Alaska Natives. For example, traditional stories and beliefs often feature wildlife and the relationships between humans and wildlife. Hunting and fishing also provide opportunities for community bonding and the passing down of traditional knowledge from one generation to the next.

Overall, wildlife is a central and integral part of the lives and cultures of Alaska Natives, providing sustenance, income, cultural identity, and a connection to the land.

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manufacturing an item before it is needed is an example of what form of waste?

Answers

Answer:

The answer would be overproduction

In today's world, minimizing waste has become increasingly important. Manufacturing an item before it is needed is an example of overproduction, which is a form of waste.

Waste can refer to anything that is not used efficiently or effectively, and it can be found in many different areas, from manufacturing to agriculture. In manufacturing, waste can take many different forms, including excess inventory, overproduction, and defects. Manufacturing an item before it is needed is an example of overproduction, which is a form of waste. Overproduction occurs when a manufacturer produces more goods than are needed or expected, and can result in excess inventory, increased storage costs, and other forms of waste.

One of the main reasons why overproduction occurs is due to an emphasis on efficiency and speed in the manufacturing process. Manufacturers may feel pressure to produce as many items as possible in a short amount of time, in order to meet demand or beat competitors. However, this can result in excess production that is not needed, and can lead to significant waste.

Overproduction can also lead to other forms of waste. For example, excess inventory can result in increased storage costs, as well as the need for additional labor and resources to manage and transport the extra inventory. Additionally, if the excess inventory becomes outdated or obsolete, it may need to be disposed of, which can result in environmental waste.

To minimize waste in the manufacturing process, it is important for manufacturers to carefully plan and manage their production processes, and to work to improve efficiency without sacrificing quality. By focusing on lean manufacturing principles, which emphasize minimizing waste and maximizing efficiency, manufacturers can reduce the amount of overproduction and other forms of waste in their processes. This can help to reduce costs, improve sustainability, and create a more efficient and effective manufacturing operation.

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forms channels through the membrane is descriptive of a. integral membrane proteins b. peripheral membrane proteins c. both kinds of membrane proteins

Answers

Integral membrane proteins can form channels through the membrane. These proteins are embedded within the lipid bilayer of the cell membrane and play a role in the transport of ions, molecules, and other substances across the membrane.

The channel formed by the integral membrane protein allows for the passive or active transport of these substances, depending on the type of channel.

Peripheral membrane proteins, on the other hand, are not embedded within the lipid bilayer but instead are attached to the surface of the membrane via hydrophobic or electrostatic interactions. They do not form channels through the membrane but instead play a role in regulation, signaling, and other cellular processes.

So, the statement "forms channels through the membrane" is descriptive of integral membrane proteins.

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The setting of Clarissas story is a key component of the plot. How is this type of setting BEST described?pervasiveatmospherebackdropintegral The authors most likely reason for writing this passage is blank he English Bill of Rights put limits on the power ofParliament.the army.the monarchy.the judiciary. how does the audience gains greater knowledge of the personalities of romeo and juliet Which of the following best describes how to administer Tdap vaccine to an adult woman who weighs 195 lbs?Subcutaneously at a 45-degree angle in the outer aspect of the upper armSubcutaneously at a 45-degree angle in the deltoid muscleIntramuscularly at a 90-degree angle in the deltoid muscleIntramuscularly at a 90-degree angle in the outer aspect of the upper arm Please help me with e its too hard for me how did the fear of communism and socialism in the usa lead to the red scare? How do I ask a answer POPULATION A city's population is 358,000 and is decreasing at an annual rate of 0.25%.Which function represents the estimated population after "t" years? Your company is now requiring all workers to donate 10% of their salary to charity to promote community involvement and to make the company look better. Do you agree with this change or not? Explain your reasoning and support your response with examples. angelique builds a fence. After working for 2 5/6 hours, she has built 5/8 of the fence. In the space below, define urbanization and develop an argument that identifies the social and economic conditions that supported urbanization.HELP PLEASE I AM NOT GRADUATINGand if your one of those a-holes who just but random numbers for the points then your soooooo hilarious. I hope your proud of yourself. Find and interpret the marginal frequencies. Cell Phone Company A B Data Plan Limited 78 94 Unlimited 175 135 people have a limited data plan. people have an unlimited data plan. people use Company A. people use Company B. people were surveyed. Skip to navigation what do these two changes have in common? three balloons filled with three different gaseous compounds each have a volume of 22.4, would these ballons have the same mass? The Industrial Revolution created a demand for raw materials. This demand led to the answer choicessocial revolutions of Europe and Americaagricultural revolution in England and Scotlandfamines in India and Irelandcolonization of Africa and Asia If each cord can sustain a maximum tension of 50 N before it fails, determine the greatest weight of the flowerpot the cords can support. In a Pew poll of American voters, almost 80% of Democrats say the governmentshutdown is a "very serious" problem for the country, while just 35% of Republicans feelthe same. 54% of the people polled were Democrats and 46% were Republicans.(a) Overall, what percentage of American voters say the government shutdown is a"very serious" problem for the country?%Answer=(b) Set up a 2x2 probability table. Round all percentages to 2 decimal places.DemocratRepublicanTotalSeriousNot SeriousTotal which term best describes a personn who belives in minimal government regulationson businesses and has a strong regard for personal freedoms the nurse would question the use of milrinone in a patient with which condition? acute renal failure aortic regurgitation systolic heart failure mitral valve prolapse