Warfarin acts by inhibiting the activity of the VKORC1 protein, which helps to produce functional clotting factors. There is a variant in the VKORC1 gene that lowers the dose of warfarin required for treatment, and individuals with this variant have increased risk of bleeding when they are treated with warfarin. This variant is found 1639 base pairs upstream of the translational start site. This variant likely:______.
a. decreases the activity of the VKORC1 protein.b. increases the activity of the VKORC1 protein.c. decreases expression of the VKORC1 gene.d. increases expression of the VKORC1 gene.

Answers

Answer 1

Answer:

The correct answer - c. decreases expression of the VKORC1 gene.

Explanation:

Mutation of Guanine nucleotide into Adenosine is the reason for this particular type of mutation. This mutation expresses the less expression of the VKORC1 protein.

The mutation results in a decrease in the affinity of the binding site of the transcription factor which causes less expression. Since the VKORC1 protein is less in the body so Warfarin doses are decreased  

Thus, the correct answer is - decreases expression of the VKORC1 gene.


Related Questions

Defined forestry and its important in nepal?​

Answers

Explanation:

In a mountain- ous country such as Nepal, forests are important for the protection of water catchments, the conservation of soil and the maintenance of biodiversity, as well as for their contributions to sustainable rural livelihoods and the maintenance of the environment.

Answer:

forest is defined as a large area that has many trees and other plants, or a dense area that is like a forest.

its important in nepal are:

1.for the protection of water catchments,

2.for the conservation of soil and

3.for the maintenance of biodiversity,

4.. for their contributions to sustainable rural livelihoods

5.the maintenance of the environment.

6.it increase the natural beauty of nepal

हरियो वन नेपालको धन

जय नेपाल

3. Explain the main difference between organisms of the
domains Bacteria and Archaea and organisms of the domain
Eukarya.

Answers

Answer:

Both Bacteria and Archaea are prokaryotes, single-celled microorganisms with no nuclei, and Eukarya includes us and all other animals, plants, fungi, and single-celled protists – all organisms whose cells have nuclei to enclose their DNA apart from the rest of the cell.

Explanation:

Both Bacteria and Archaea are prokaryotes, single-celled microorganisms with no nuclei, and Eukarya includes us and all other animals, plants, fungi, and single-celled protists – all organisms whose cells have nuclei to enclose their DNA apart from the rest of the cell.

1. What features are located medial to the cranium and the mandible. Identify the category here.
2. How many individual items are included in this category?

Answers

The features that are located medial to the cranium and the mandible are:teeth,tongue, lips, chick hard andsoft palate,

   2. There is a total of six individual items in this category.

The human skull is made up of two parts, the cranium, which contains the face and the brain and the only movable bone called the mandible or lower jaw.

The features that are medial to the cranium and the mandible are those structures that are nearer to the mid-line.

The above mentioned features works together to provide the following functions of the cranium:

protection of the delicate structures including the brain, eye and the inner ear.maintaining patency of the nasal passage enabling breathing.the movement of the mandible allows chewing.

Learn more here:

https://brainly.com/question/20273756

.

While snorkeling in the ocean you find large, leafy organisms that are brownish in color growing in large masses. You are unsure whether they are protists since they look quite plant-like. If they are actually protists, what characteristic will the organism's cells exhibit?

A. Each of the cells in the organism will have its own nucleus.

B. The cells will form a colony with separate groups of cells doing various jobs.

C. The cells will form a colony without differentiating into separate tissues.

D. Most of the cells in the organism will have cilia or flagella.

Answers

Answer:

A. Each of the cells in the organism will have its own nucleus.

Explanation:

While snorkeling in the ocean you find large, leafy organisms that are brownish in color growing in large masses. To be sure that they are protists since they look quite plant-like, the characteristic that the organism's cells exhibit will be that each of the cells in the organism will have its own nucleus.

This is because protists are eukaryotes, which simply means it has its own nucleus and are usually single celled.

What are physical and chemical properties

Answers

physical property: Any characteristic that can be determined without changing the substance's chemical identity. chemical property: Any characteristic that can be determined only by changing a substance's molecular structure.

Take the gram seeds. Divide the seeds into three sets A, B and C.
➢ Put the seeds of set A onto the moist cotton.
➢ Soak the seeds of set B in the water overnight and then put on the moist cotton for seed germination.
➢ Put the seeds of set C in the boiling water for some time then allow it to germinate on the moist cotton.
➢ Grow a plant in another set.
➢ Note the observations every week.
Set A
Set B
Set C
Plant 1 st week 2 nd week So on….

Answers

Explanation:

set A ,seeds will germinate

set B,seeds will rot due to the presence of alot of water

set C,seeds will not germinate

Which is a source of adult stem cells?
bone marrow
amniotic fluid
embryos
gametes

Answers

Answer:

Bone marrow is a source of adult stem cell

why are electrons in an atom involved in bonding

Answers

Answer:

The valence electrons have a role in the bonding of two atoms. The nuclei of each atom are drawn together by their attraction to the valence electrons of the other atom. As the atoms are drawn together by their attractions, electrons from each atom are drawn to the nuclei of both atoms, where they are "shared."

OAmalOHopeO

Which is true if energy in ecosystem

Answers

Explanation:

energy flows in only one direction through an ecosystem.

I never thought of that these statements alone are not
sidered for a grade
Answer the questions) below
A former patient comes into the dental office and states that she has recently been diagnosed with skin cancer. She demands her xrays and treatment record and claims that she was exposed to unnecessary radiat
during her visits How should the dental assistant respond? Can the dental assistant be held responsible?

Answers

Answer:

geuueieiejrjejdjjhdjsjdjsjeiei do it is custom returns and more and more than more and then send it out in a no to a good morning to kya hua hai aapko ❤️❤️ ab workouts and more ab mai

In the aerobic metabolism of proteins by chemoheterotrophs (e.g., E. coli and you):____.
A. Proteins are broken down into smaller peptides and eventually into amino acids by proteases (peptidases).
B. Certain amino acids may be converted to pyruvate.
C. Certain amino acids may be converted to intermediates (e.g. oxaloacetate) of the Krebs cycle.
D. Certain amino acids may be converted to acetyl-CoA.
E. All of the above are true.

Answers

The answer is A because
A) proteins are broken down into smaller peptides and eventually into amino acids by proteases

What is your opinion about climate change ?

Answers

A scientific consensus on climate change exists, as recognized by national academies of science and other authoritative bodies. The opinion gap between scientists and the public in 2009 stands at 84% to 49% that global temperatures are increasing because of human-activity.

3. The DNA double helix is stabilized by hydrogen bonds between:

Answers

Answer:

Between Dioxide and Ribonuse Acid

Explanation:

hope it helps

Answer:

The structure of the DNA helix is stabilized by van der Waals forces, hydrogen bonds between complementary organic bases (a base pair), and hydrophobic interactions between the nitrogenous bases and the surrounding sheath of water

In the lung alveoli, the oxygen partial pressure is about 100 mm of mercury, or 0.13 Atm. If blood was solely composed of a saline solution (lacking any hemoglobin), oxygen equilibrates with the alveolar air to a concentration of about 3 mg/L or 0.093 mm). In oxygen-saturated blood, however, the O2 concentration is about 0.008 M (8 mm).

Required:
a. What is the Henry's Law constant for oxygen in saline?
b. What is the Henry's Law constant for oxygen in blood?
c. How much does the presence of hemoglobin enhance oxygen solubility in blood (i.e. what is the ratio in blood vs saline)?

Answers

Answer:

Picture is attached.

Why is earth science important ?

Answers

Answer: The knowledge gained and the services provided by earth scientists help society cope with its environment in many ways. ... Their knowledge about the structure, stratigraphy, and chemical composition of the earth's crust helps us locate resources that sustain and advance our quality of life. hope this helped :)

An adult giraffe (Giraffa camelopardalis) has a heart that lies approximately 2 m below the top of the head when its neck is fully extended. Calculate the minimum diastolic pressure that a giraffe must have (in mm Hg). Hint: what is the absolute minimum blood pressure a giraffe could have at the very top of its head

Answers

Answer:

159.01 mmHg

Explanation:

position of Heart = 2m  below the top of the head  given that the neck is fully extended

Determine the minimum diastolic pressure

Minimum diastolic Pressure = 1060 kg/m^3 * 10 m/s^2 * 2m

                                               = 21200 kg/m^2

convert the value to Pa

21200 kg/m^2 = 21200 Pa

( 1 pa = 0.00750062 mmHg )

Therefore : minimum diastolic pressure = 21200 * 0.00750062 = 159.01 mmHg

The minimum diastolic pressure that a giraffe must have is 150 mmHg

Diastolic Blood pressure

Diastolic Blood pressure is the pressure on the walls of your arteries between heartbeats, that is when the heart is resting.

The minimum diastolic diastolic blood pressure = absolute minimum blood pressure a giraffe could have at the very top of its head.

Pressure formula

P = hpg

where;

P = pressure

h = height difference

p = density

g = acceleration due to gravity

Density of blood = 1000 kg/m^3

h =2.0 m

g = 10 m/s^2

Pressure = 1000 × 2.0 × 10

Pressure = 20000 Pascal or 20 kpa

Converting to mmHg

1 kpa = 7.50 mmHg

20 kpa = 20 × 7.50

Pressure = 150 mmHg

Therefore, the minimum diastolic pressure that a giraffe must have is 150 mmHg

Learn more about diastolic blood pressure at: https://brainly.com/question/14661197

The statement that there must be a preexisting cell in order for a new cell to form is known as cell

Answers

Answer:

cells duplicate so when there is no cell it cant make any

Explanation:

The statement that there must be a preexisting cell in order for a new cell to form is known as cell theory.

What is cell theory?

The scientific idea that cells make up living organisms, that they are the fundamental structural and organizational unit of all species.

They all originate from previously existing cells is known as cell theory. It was first proposed in the middle of the nineteenth century.

Because cells are the building blocks of all life, cell theory is essential for our understanding of biology.

We can have single-celled organisms like yeasts and bacteria. All living things grow and develop on the basis of cell division, or the division of a cell from one to two to four.

A vital process for life is mitosis. A cell divides into two identical daughter cells after duplicating all of its components, including its chromosomes.

Thus, the statement "cell arises from pre-existing cells" comes from cell theory.

For more details regarding cell theory, visit:

https://brainly.com/question/1468725

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Name ten infrasonic animals.

Answers

Whales, rhinos, squid, cuttlefish, hippos, elephants, octopus, pigeons, squid, cod, guinea fowl

Which genotype would give you a wild type phenotype?

Answers

Answer:

C

Explanation:

make slogan about showing care of environment and natures​

Answers

plant trees at least every year and keep atmosphere clear

Which of the following was not part of the original cell theory, but was added later after we learned more about cellular structure​

Answers

where is full question man

Which of the following is the best definition of an atom?
O A. A particle within the nucleus that has a neutral charge
B. A negatively charged particle that circles the nucleus
C. The fundamental unit of all matter, both living and nonliving
O D. A positively charged particle within the nucleus
SUBMI

Answers

Answer:

C. The fundamental unit of all matter, both living and nonliving

why is climate change a serious threat to the least developed countries practicing agriculture as their main occupation mountain region island and low lying countries​

Answers

Answer:

Increase in sea level on the low lying countries which leads to degradation and salinification thereby making the soil non-arable. Meanwhile on the mountain regions, melting glaciers caused by rain falling on snow leads to mountain floods, avalanches and extreme rockslide and thereby disrupting agricultural produce and wildlife.

Explanation:

differences between a fish and a toad.​

Answers

Answer:

⬇ See answer below ⬇

Explanation:

A fish is a(n) aquatic animal which has gills and can only find oxygen underwater. Toads are quite different though as they are amphibians who can live on both land and underwater. (Hope this helped you!)

In human populations of northern European origin, the disorder called hemochromatosis causes excess iron uptake from food and affects one in 200 adults. Among individuals 15 to 50 years old, men are ten times as likely as women to suffer from iron overload. Part A Taking into account this range of ages, what explains this difference

Answers

Answer:

Females of reproductive age lose iron through menstrual blood

Explanation:

Iron is an essential micronutrient involved in the formation of hemoglobin, myoglobin and many enzymatic groups. Moreover, hemochromatosis is a genetically inherited disorder caused by mutations in genes associated with the processes of absorption, transport and storage of iron. The excess of iron is stored in different organs (e.g., liver, heart, pancreas, etc), causing characteristic tissue damage. During each menstrual cycle, women and girls suffer a blood loss of approximately 40 ml, which is associated with an average loss of 1.6 mg of iron. In consequence, it is expected that women of reproductive age (ie, 15–49 years) lose iron during their menstrual periods, thereby avoiding iron overload caused by hemochromatosis.

IN____________ NUTRITION , THE ORGANISMS DEPEND UPON ITS HOST FOR ITS FOOD .

Answers

Answer:

heterotrophic nutrition!!

You are carrying a case of 24 bottles of water up the stairs to your third-story apartment. What type of contraction are the muscles in your arms experiencing

Answers

Answer:

Concentric contraction.

Explanation:

Concentric contraction is a type of contraction that the muscles in arms experiencing when an individual lifting 24 bottles of water up the stairs. A concentric contraction is a type of muscle activation that creates tension on your muscle as it shortens. As your muscle shortens, it produces enough force to move an object in the upward direction. In weight training we can easily see concentric movement.

animals with scales on skin are called?



Answers

Answer:

Animals with scales on their skin are called reptiles..

hope it helps

stay safe healthy and happy...

purple flower = P
white flower = p
round seed = R
wrinkled seed = r

look at the punnett square and list the genotypes that would correspond to each phenotype

purple flowers, round seeds:
purple flower, wrinkled seeds:
white flowers, round seeds:
white flowers, wrinkled seeds:​

Answers

Answer: this is a long one lol

Explanation:

purple flowers and round seeds could be both PPRR and PpRr because it's both dominant traits and heterozygous genotypes still show the phenotype of the dominant gene. purple flower and wrinkled seeds would be PPrr or Pprr for the same reason. white flowers and round seeds would be ppRR or ppRr, and finally white flowers and wrinkled seeds would be pprr. hope this helped :)

In the respiratory system certain structures allow air to pass from the trachea to the lungs. They are lined with thin
muscles and coated with epithelial cells.These structures are called
O bronchial tubes.
O alveoli.
O bronchioles.
O lobules.

Answers

Answer:

bronchioles are the structure

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Select the correct answer from each drop-down menu. Study the graphs, and then complete the passage. An anomaly in global temperature is a deviation from what is normal or expected. The graph shows that global atmospheric co2 ___(increased exponentially. Remained constant. Increased slightly)in the twenty-first century, and global temperature also increased during the same time. Based on the timeline, these statistics suggest a correlation between climate change and ___(wind energy production. Use of electric cars. Industrial carbon emissions). If the current trend of increasing co2 levels continues, the greenhouse effect will continue to ___(warm the planet. Release gas into space. Destroy carbon dioxide) . How many moles of water vapor are formed. when 10 litres of butane gas c4h10 is burned in oxygen at STP pq eu tenho que estudar? Lee y escoge la mejor respuesta. Read and select the best answeEl ttulo acadmico que recibes al acabar estudios superioresuniversitarios de aproximadamente cuatro aos esO el doctoradoO el ttulo asociadoo la licenciaturaO la maestra In "Civil Peace," why does Jonathan lwegbu bury his bicycle? Andrew walks through his garden and observes that the shapes of dewdrops are not always the same. Suppose he wants to investigate using the scientific method. Which questions are testable questions that he can ask to look into the reasons for the different shapes?Does the shape of the dewdrop depend on the temperature of the surface?Which dewdrop seems to have the most unusual shape?Is the material of the surface responsible for the shape of the dewdrop?Which shape of dewdrop is the most pleasing to the observer?Does the shape of the dewdrop depend on the moisture in the atmosphere? Mercedes has decided that she wants to be an electrician. She discovers that her local power company has a program where she can get on-the-job experience and go to school. This will eventually get her the background she needs to be an electrician. What kind of program is this?A. gap yearB. apprenticeshipC. advanced degreeD. certificate program A sample of 10.6 g of KNO3 was dissolved in 251.0 g of water at 25 oC in a calorimeter. The final temperature of the solution was 21.5 oC. What is the molar heat of solution of KNO3 um resumo sobre a violencia no esporte An automatic machine inserts mixed vegetables into a plastic bag. Past experience revealed that some packages were underweight and some were overweight, but most of them had satisfactory weight. Weight % of Total Underweight 2.5 Satisfactory 90.0 Overweight 7.5a) What is the probability of selecting and finding that all three bags are overweight?b) What is the probability of selecting and finding that all three bags are satisfactory? How is it possible for mad made things to move? Which philosopher's ideas wouldlikely appeal to a private businessowner?A. VoltaireB. SmithC. Diderot Where should there be a paragraph break in the following text?"Can you make me a pizza?" Franklin asked. (1.) "Make it yourself." Lisa replied. (2.) "I have had one of the worst days ofmy life and all you can do is ask me to cook for you? You can't ask about my day? You are so selfish. If you could show an ounce of interest in someone other than yourself maybe you would be able to find a job.) (3.) Franklin was stunned.A.4B.2C.3D.1 I NEED HELP WITH THIS ONE TOO !! The belief that those who make less money must not be hardworking is an example of which type of bias, prejudice, or stereotype? Ethnic/racial Gender/sexual Religious Socio-economic Does democracy require equality of income or wealth? The senior marketing executive you have assigned as team leader asks you to stay on as a team consultant until she gets things rolling. She asks your advice on her first course of action. What will you advise her to do HELP 20 points Congruence by SSS AND SAS NO LINKS Email on starting the drawbacks of online exam "All honey flora are plants, but all plants are not honey flora". Justify.