Once expressed on the surface of host cells, an MHC protein remains stably associated with its bound peptide for several days. This highly stable peptide binding behavior is important because, it prevents peptide exchanges on the cell surface, ensuring that peptide :MHC major histocompatibility complexes are reliable indicators of the proteins present inside that host cell.
Pathogen-derived peptides are loaded onto MHC class I and MHC class II molecules at various locations inside the cell, depending on whether the pathogen is located in the cytosol or the vesicular compartment of the cell. Before they may be expressed at the cell surface in a stable manner, both classes of MHC molecules need to join forces with a peptide.
In contrast, MHC class II molecules are prevented from binding peptides in the endoplasmic reticulum and are instead transported to an endosomal compartment where vesicular peptide loading takes place. Peptide-binding completes the folding and assembly of freshly synthesized MHC class I molecules in the endoplasmic reticulum.
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Afghanistan’s national government in the capital city of kabul has little influence in the country’s rural regions in large part due to the many __________ living there.
Afghanistan’s national government in the capital city of kabul has little influence in the country’s rural regions in large part due to the many ethnic factions living there.
In Afghanistan, a person's ethnicity serves as a quick and easy cultural marker and frequently establishes the social structure of a population. Pashtuns, Tajiks, and Hazaras are the three ethnic groups that are most prevalent. Uzbeks, Nuristanis, Aimaks, Turkmens, and Balochs are all present in substantial numbers (among others). In Afghanistan, the Pashtun are the majority ethnic group.
They are primarily Sunni Muslims and Pashto speakers. Historically, tribal honour rules and interpretations of Islamic law have shaped Pashtun culture and social organisation. This is referred to as "Pashtunwali" — a moral and legal code that establishes the social norms one should uphold in order to honour Islamic and cultural values. Only rural tribes generally adhere to Pashtunwali in its most rigid form. Many Pashtun behaviours, though, continue to reflect its impact.
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For many years, there was only one long-distance telephone company in the united states—the american telephone and telegraph company. this company was an example of a(n)?
For many years, there was only one long-distance telephone company in the united states—the american telephone and telegraph company. this company was an example of a(n) monopoly.
Monopoly is an economy-themed multiplayer board game. In the game, players roll dice to move around the game board, buy and trade properties, and develop in houses and hotels. Players collect rent from their opponents to bankrupt them. Money can also be gained or lost through random and community cards and control squares. Players receive a prize for each "Go" they pass and may be put in jail, from which they cannot move until they meet one of three conditions.
House Rules exists in hundreds of different editions, many spin-offs and related media. Monopoly has become part of international popular culture, with local licenses in over 103 countries and printed in over 37 languages. As of 2015, the game is estimated to have sold him 275 million copies worldwide.
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What effect did the creation of decentralized boards and other districts outside the authority of the governor have on the texas government?.
It created a system more vulnerable to special interests in the texas government.
It's easier in Texas to impeach than in the national government. In recent years, most proposed constitutional amendments have been accepted.
Mexican policy restricted immigration from the United States to Texas. The Texans felt underrated. Education was often provided only in Spanish.
Anglo settlers saw themselves as part of America's westward expansion rather than as Mexican citizens. The Texans wanted a bilingual education. The Texans resented Mexico's restrictions on civil liberties.
The governor of Texas can use vetoes in a variety of ways to oppose legislative action, and different types of vetoes have specific characteristics.
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The minimum diameter of galvanized pipe allowed for a grounding electrode is______.
The minimum diameter of galvanized pipe allowed for a grounding electrode is 3/4
This is further explained below.
What is an electrode?Generally, An electrolyte, a semiconductor, or a vacuum are all examples of non-metallic circuit components that may be contacted by an electrode. Electrodes are electrical conductors that make contact with these components. In the context of an electrochemical cell, this component may alternatively be referred to as an anode or a cathode.
In conclusion, 3/4 of an inch is the smallest diameter of galvanized tubing that may be used as a grounding electrode.
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The body of your informative speech should NOT:
Select one:
O a. Have three main points
O b. Be arranged in logical sequence
O c. Be completely memorized
O d. Have transition statements
Answer:
The body of the speech should NOT be completely memorized .
Explanation:
Not unless one has got abnormal mental abilities , a person cannot memorize the entire body of a speech leave alone being informative or typical to any field ,.
Is it really possible for a person to memorize like 1000 words in the correct order in which they have been written ? The answer is no as this is a huge volume of words .One thousand is just an example as they can be more or less .
The other three points are correct as they are feasible .For instance the body part of a speech contains the main point therefor 'A' is correct .As for 'B' arranging the point in a logical sequence is in order as it implies the reality of the speech and also brings logical sequence and flow of ideas .
Finally 'D' providing transition statements ensures that the speech has a flow of ideas and the audience can connect and relate to the ideas just as the reader or writer understands it .
What strategic activity is the major league baseball (mlb) brand pursuing in order to expand its popularity among younger target segments?
Engaging in new product development is the strategic activity that the major league baseball (MLB) brand pursuing in order to expand its popularity among younger target segments.
The majority of Major League Baseball's target market consists of males between the ages of 18 and 49. According to TV Quarterly Magazine, this demographic attracts advertisers due to its perceived worth. It is believed that these potential customers are more likely than older ones to switch brands or product preferences. However, it has been challenging for the national pastime to get to this point. A 2013 Nielsen survey found that 50% of viewers of MLB's regular season in 2013 were 55 years of age or older.
The methods and steps taken to introduce new items to the market or alter existing products to spur the growth of new businesses are referred to as product development strategies. From creating an idea to providing goods to clients, there are various processes involved in developing a product. To be effective and produce income for a firm, each stage needs a strategy.
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What best describes the carrot and stick approach to maintaining an ethical corporate culture?
One of the best example of this approach is;
Giving bonuses on timely (or before) completion of goals and deducting salary for not completing tasks on time.
or
Giving paid time off is an another example of a carrot and giving works on unfavourable timmings is an example of a stick.
The carrot is the reward for completion of the given task, and the stick is like a punisment which can be given for many reasons like, long pending tasks, not complying with the company policies, etc.
The origins of this approach is considered as to be emerged as a result of the need to motivate the employees to do important and qualitative work in exchange of the various rewards they get.
The general idea behind this a[[roach is, that the humans are lazy and they do not do quality work till they do not get some kind of Catalyst, and here the carrot and the stick works as the catalyst.
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A country has an absolute advantage if it can produce _______ good using _____ inputs than another country.
Answer:
enough using low
Explanation:
a country has an absolute advantage if it can produce enough goods using low inputs than another country
Because of his uneven academic performance in your class, you suspect that Justin, one of your students, has a learning disability. Of the following, which is the first step you should take in attempting to get additional help for him
You must first describe the problem including how it is affecting Justin's academic performance, the strategies you've tried to solve it, and how well the strategies have worked.
Training replacement instructors in studies-primarily based on academic strategies and effective study room control. Creating a classroom revel that reinforces substitutes' knowledge and builds each self-assurance and skills.
Spotting and reinforcing advantageous behaviors is one of the only methods to provide high-quality movements in college students, fortify intrinsic motivation, and create productive and positive studying surroundings.
An experience of belonging and identity. Effective social norms. possibilities for skill-building, choice-making, and making plans. Social and cultural integration of the family and the community.
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Your question is incomplete. Please find the complete question below.
Because of his uneven academic performance in your class, you suspect that Justin, one of your students, has a learning disability. Of the following, which is the first step you should take in attempting to get additional help for him?
A) You must first report your findings to the exceptional student specialists in your school. Once you have filed your report, your responsibility has been met.
B) You must first describe the problem including how it is affecting Justin's academic performance, strategies you've tried to solve it, and how well the strategies have worked.
C) You must first report your findings to the exceptional student specialists in your school. If diagnosis confirms an exceptionality, you will be expected to accommodate your instruction to meet Justin's needs as effectively as possible.
D) You must first report your findings to the exceptional student specialists in your school, and if diagnosis confirms an exceptionality, Justin will be removed from your classroom and placed in a special class. You will be expected to accommodate his needs the best you can until he is removed.
Research suggests that a firm with greater multimarket contact is ____________ likely to initiate and attack, and____________ likely to respond aggressively when attacked
Research suggests that a firm with greater multimarket contact is less likely to initiate an attack, and more likely to respond aggressively when attacked.
Research is described because of the introduction of recent expertise and/or the usage of present expertise in a brand new and creative way as a way to generate new principles, methodologies, and understandings. this could encompass synthesis and evaluation of preceding studies to the quantity that it leads to new and creative results.
Studies is largely an intellectual technique that helps you examine a certain phenomenon or subject matter primarily based on personal, instructional, and/or company hobbies. There are unique methodologies and tools for doing it. Please conduct similar studies that will help you solve your query.
Research is "creative and systematic work undertaken to increase the stock of expertise". It includes the gathering, corporation, and evaluation of data to boom expertise on a topic or difficulty. A studies mission may be a diffusion of past work within the field.
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Gisela had a history of depression. But one day, she wakes up feeling very energetic. Inspired to paint, she spends three straight days productively creating works of art. She sleeps very little; she says that she doesn't need sleep because she's not at all tired. It is likely that Gisela is suffering from:
wakes up feeling very energetic and doesn't need sleep because she's not at all tired
What is Bipolar Disorder ?A disorder associated with episodes of mood swings ranging from depressive lows to manic highs.
The exact cause of bipolar disorder isn’t known, but a combination of genetics, environment and altered brain structure and chemistry may play a role.Manic episodes may include symptoms such as high energy, reduced need for sleep and loss of touch with reality. People with bipolar experience both episodes of severe depression, and episodes of mania – overwhelming joy, excitement or happiness, huge energy, a reduced need for sleep, and reduced inhibitions.Learn more about Bipolar Disorder here:
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Scalloped patterns of responding are typically associated with which schedule of reinforcement?.
Scalloped patterns of responding are typically associated with Fixed interval schedules. This is further explained below.
What are Fixed interval schedules?Generally, Fixed-interval schedules are ones in which the first answer will not be rewarded until a certain length of time has passed from the beginning of the schedule.
In conclusion, Responses that follow a scalloped pattern are often connected with programs that use fixed intervals.
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Which best describes how the supreme court voted in brown v. board of education? the court voted to hold a national debate on school segregation. the court voted to maintain school segregation. the court voted to leave school segregation up to individual states. the court voted to end school segregation.
In the case of Brown V. Board of Education, the court voted to end school segregation.
The ruling of the case "Brown vs the Board of education" is, that racial segregation is unconstitutional in public schools. This additionally proves that it violated the 14th amendment to the constitution, which prohibits the states from denying equal rights to any man or woman.
In Brown v. Board of education, the U.S. ideally suited court docket dominated unanimously that racial segregation in public colleges violated the Fourteenth change to the constitution. The 1954 selection declared that separate instructional centers for white and African American college students had been inherently unequal.
The courtroom then concluded its highly short opinion via putting forward that segregated public schooling turned into inherently unequal, violated the same protection Clause, and therefore turned into unconstitutional: We conclude that in the field of public education the doctrine of "separate but equal" has no place.
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Answer: D
Explanation: The court voted to end school segregation in Brown v. Board of Education.
In what ways was the delian league successful and in what ways was it unsuccessful?
The Delian League was successful because it enjoyed success against the Persians in the 470s and 460s.
What was the Delian League?The League which was created in 478 BCE after Persian War was a military alliance against any enemies that might threaten Ionian Greeks.
The military alliance was led by Athens that protected all members that are unable to protect themselves with its massive and powerful navy.
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Sociologists inspired by the _____________ perspective would point out that innovation drives the economy and employment can launch the innovator into the ranks of the wealthiest.
Sociologists inspired by the functionalist perspective would point out that innovation drives the economy and employment can launch the innovator into the ranks of the wealthiest.
What is a Functionalist Perspective?The functional perspective, which emphasizes the functions of inputs and/or processes, is a normative method for describing and forecasting group performance. From this angle, the goal of theory and study is to comprehend why some groups are successful while others are not.According to the functionalism hypothesis, society is an intricately intertwined web of social patterns and structures that serves the needs of its constituent members.The British anthropology field gave rise to functionalism. For instance, Bronislaw Malinowski, a Polish-British anthropologist, suggested functional analysis as a way for sociologists to analyze social circumstances intuitively rather than by observation in 1943.To learn more about Functional perspective refer to:
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Based on MRI research on people who were experiencing and later resolved cognitive dissonance, what would you expect to happen to Mary, who just reduced her dissonant feelings about visiting the tanning salon by telling herself that she isn't genetically predisposed to skin cancer, so it won't affect her
Based on MRI research on people who were experiencing and later resolved cognitive dissonance She will experience pleasant feelings.
What Is Cognitive Dissonance?Psychological conflict resulting from simultaneously held incongruous beliefs and attitudes (as a fondness for smoking and a belief that it is harmful) .
The term cognitive dissonance is used to describe the mental discomfort that results from holding two conflicting beliefs, values, or attitudes. People tend to seek consistency in their attitudes and perceptions, so this conflict causes feelings of unease or discomfort.
This inconsistency between what people believe and how they behave motivates people to engage in actions that will help minimize feelings of discomfort. People attempt to relieve this tension in different ways, such as by rejecting, explaining away, or avoiding new information.
Some signs that what you are feeling might be related to dissonance include:
Feeling uncomfortable before doing something or making a decisionTrying to justify or rationalize a decision that you've made or an action you have takenFeeling embarrassed or ashamed about something you've done and trying to hide your actions from other peopleExperiencing guilt or regret about something you've done in the pastTherefore , we can conclude that the correct option is B.
Your question is incomplete, but most probably your full question was:
Based on MRI research on people who were experiencing and later resolved cognitive dissonance, what would you expect to happen to Mary, who just reduced her dissonant feelings about visiting the tanning salon by telling herself that she isn't genetically predisposed to skin cancer, so it won't affect her?
a. She will next experience nervousness.
b. She will experience pleasant feelings.
c. She will be able think critically about other things.
d. She will be unable to encode new memories for up to ten minutes.
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The ____ hypothesis states that long term environmental unpredictability led to morphological and behavioral adaptations.
The Variable selection hypothesis states that long term environmental unpredictability led to morphological and behavioral adaptions.
A Hypothesis is a type of suggestion which gives foe an event,can be tested. variable selection proposes that major features of human evolution were actually ways that our ancestors more adaptable.
Its a natural form that explains adaptation as a response to dramatically increased variability in the environment. when climate and other factors of environment vary drastically , it can really affects the organisms and other offspring over the time.
It's a process of selection of adaptation to environmental variability.A variable is a part of the experiment that can be change during an experiment.
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A between conditions analysis of the values of data in one condition that are the same as those in an adjacent condition is known as:_____
A between conditions analysis of the values of data in one condition that are the same as those in an adjacent condition is known as overlap.
It may be helpful to think of overlap as the percentage of data points in the intervention condition which are not improved relative to baseline when discussing the extent to which data through one state are at the same level as data from a neighboring condition. Since level is frequently the data change that interventionists care about the most, it may not be unexpected that early attempts to measure visual analysis of change across conditions were focused just on extent to which data were not overlapping in the anticipated direction, since non-overlap of data frequently coincides with variations in level.
So it is perhaps not surprising that level is often the data change that is most important to interventionists.. Thus, the amount of overlap is significant since it indicates level change, even if PND and other methods of quantifying overlap are quite sensitive to procedural factors. that is, both the study methods and the results have a significant impact on how well overlap-based indicators reflect changes in level.
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_____ validity is the extent to which findings may be generalized, while _____ validity refers to the ability to infer that there is a causal relationship between variables.
External validity is the extent to which findings may be generalized, while internal validity refers to the ability to infer that there is a causal relationship between variables.
Internal validity is the degree to which the observed effect can be reliably attributed to the independent variable. Internal validity is attained if only the independent variable(s) are responsible for the dependent variable's effect. This is the level of manipulation that can be applied to a result. In other words, internal validity is a measure of how well your research "works" in a research environment. Does the variable you alter inside a particular study have an impact on the variable you're examining?
The term "external validity" describes how far a study's findings can be extrapolated from the sample. Which means you may use the information you learn to make adjustments for different scenarios and people. Consider this as the extent to which a result can be generalized. How well do the research findings translate to the rest of the world? A controlled environment with fewer variables is a laboratory setting (or other research setting). The term "external validity" describes how well the findings stand up in the presence of all those other variables.
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The _____ definition of a variable explains the variable in terms of the set of procedures used to measure or manipulate it.
The operational definition of a variable explains the variable in terms of the set of procedures used to measure or manipulate it.
An operational definition of a variable is the set of procedures which are used to measure or manipulate it. A good operational definition is clear enough so that an independent researcher could use the same procedure and get the same results.
Here, the the independent variable is the cause. Its value is independent of other variables in your study.
For instance, the operational definition of anxiety could be in terms of a test score, withdrawal from a situation.
Hence, the operational definition of a variable explains the variable in terms of the set of procedures.
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A major city of the pre-vedic culture of the indus river valley was :______
A. Harappa.
B. Benares.
C. Madras.
D. Pataliputra
A major city of the pre-Vedic culture of the Indus river valley was Harappa.
A pre-Aryan civilization, according to the majority of historians, was the Indus Valley Civilization. A rich Vedic culture was gradually developed after the Aryan-speaking people who formerly colonized India arrived from the Central Asian steppe highlands. The two most well-known cities of this civilization that have been excavated are Harappa and Mohenjo-Daro, which are both considered to have once been home to populations of between 40,000 and 50,000 people. This is astounding when one considers that the average population of ancient towns was 10,000.
Indus River valley is where the Harappan civilization was situated. Mohenjo-Daro and Harappa, two of its major cities, were situated in Punjab and Sindh, respectively, in modern-day Pakistan. Both the Gulf of Khambhat in the south and the Yamuna (Jumna) River in the east were within its scope.
Hence, option A is the correct answer
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Which risk is most effectively mitigated by an upstream internet service provider (isp)?
Distributed denial of service is the Which risk that is most effectively mitigated by an upstream internet service provider (isp).
An internet service provider (isp) is an organization or company that provides services and techniques for accessing, using, or participating in the Internet.
An internet service provider (isp) has the equipment and the telecommunication line access required to have a point of presence on the internet for the geographic area served.
An ISP may sell one or more types of internet service, also called connection types. The most common types are cable, fiber, DSL (Digital Subscriber Line), and satellite internet.
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Describe two ways the u. s. government tries to encourage advances in technological knowledge.
The American government provides research funds in an effort to promote the advancement of technological knowledge.
The National Science Foundation, the National Institutes of Health, tax benefits for businesses that invest in research and development, and the patent system are all ways that the American government strives to promote the advancement of technological knowledge.
The government can use a number of different policy instruments to boost the rate of return for new technology and promote its development, including direct government funding of R&D, tax incentives for R&D, intellectual property protection, and establishing partnerships between universities and the private sector. The two that work best are direct funding of technical education institutions to increase the quantity and quality of technical knowledge taught to students, and the awarding of grants for research and development of new technological projects.
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What is the first step a student needs to take to request an accommodation from services for students with disabilities?.
A student must follow the steps mentioned below:
1. Identify yourself as a student with a disability on campus.
Contact the disability services access center to register as a student with a disability and obtain college disability services. A representative will typically be available to meet with you in person or virtually to discuss your impairment, the accommodations you've already received, and the services that are accessible to you.
2. Give proof of disability
Colleges and universities will require sufficient evidence of your handicap before making any accommodations. Depending on your disability, this can include a current medical report or a psychological assessment.
3. Meet with a Representative from the Disability Services Office
After assembling all the necessary paperwork, schedule a formal meeting with a college disability services representative. You'll provide your supporting paperwork at this conference, along with specifics on the difficulties your impairment has caused you. You will also talk about the kinds of accommodations you require to succeed in college.
4. Notify the Professors if You Need Accommodations
Notify your lecturers to begin arranging accommodations once the disability services office has verified your eligibility. You will normally receive a letter as a confirmation, but you might also get an email instead of or in addition to a letter. After that, you can give your instructors access to this documentation.
What are the common types of accommodation?The following are some of the most typical types of accommodations:
interpreters who use sign languageadjustments for taking tests, such as extra time and different formatsNote-takers/scribesSubstitutions and/or waivers for courseselevators and ramps for wheelchairsunique parking spotsKnow more about disability https://brainly.com/question/14248224
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(05.03 LC)
Which branch is the president a part of?
O Judicial
O Legislative
O Executive
O State
In which part of a newspaper would you find articles that express opinions that may not agree with those of the editor?
The opinion page expresses opinions that may not agree with those of the editor.
What topics do newspapers' opinion pages cover?Your paper's opinion section (or page), if it still has one, is where you can express your thoughts and viewpoints on current events. The editorial position of the newspaper may be written by the editor of the paper or the editorial board (a group of editors, possibly joined by other staff members or even members of the community), as well as by local or national columnists who present their own points of view, readers who submit letters to the editor, and editorial cartoons (if your paper has any literary merit at all).
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The reaction to anthony fauci's corrections of president trump's misstatements illustrates what phenomenon resulting from increased use of technology in communication and information sharing?
The reaction to Anthony Fauci's corrections of President Trump's misstatements illustrates the phenomenon resulting from increased use of technology in communication and information sharing called: "a loss of decorum and political dialogue"
How can civility be increased during communication?
Civility simply means the act of being courteous and polite. Civility during communication can be increased by doing the following:
Being Inclusive: Showing more sensitivity towards other from other "class";Being respectful no matter what: This should be evidence in the choice of words used.Being respectful of the time of othersPaying more attention to others (their time and emotion and words)Acknowledging other peopleRegardless of what the channel of communication is, it is possible and indeed required for one to be and remain respectful and civil.
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Attribution theory suggests that we use two primary dimensions to develop judgments about others’ behaviors:______.
Attribution theory suggests that we use two primary dimensions to develop judgments about others’ behaviors: internal-external and stable-unstable.
Dimensions can also be used to measure position. The distance from the launch point to the position can be measured by longitude, latitude, and altitude. These distances are a measure of position. In some cases, a fourth (4D) dimension, time, is used to indicate the location of an event in time and space.
Example: Width, Depth, and Height are dimensions. Lines have one dimension (1D), squares have two dimensions (2D), and cubes have three dimensions (3D). In physics, it can also mean physical quantities such as length, time, and mass.
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What discovery revealed that the heavens weren't fixed and our interpretation of many scriptures was wrong
Brahe's Supernova discovery revealed that the heavens weren't fixed and our interpretation of many scriptures was wrong.
The Bible is a collection of religious texts or scriptures sacred to Christianity, Judaism, Samaritanism, and many other religions. The Bible is an anthology originally written in Hebrew, Aramaic, and Koine Greek.
These texts include but are not limited to instructions, stories, poems, and prophecies. A collection of material accepted as part of the Bible by a particular religious tradition or community is called a biblical canon. Believers generally view the Bible as a product of divine inspiration, understand what it means, and interpret the text in a variety of ways.
Religious texts were compiled by various religious communities in various official collections.
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Every marine is expected to show competence, courage, and ________ during combat
Every marine is expected to show competence, courage, and resolution during combat. This is further explained below.
What is a marine?Generally, A member of land or sea-trained military units, such as the Royal Marines or the Marine Corps.
In conclusion, Every marine must demonstrate expertise, bravery, and wheel torque in battle.
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