In a DNA strand, the nucleotides are linked together by
A. glycosidic bonds
B. phosphodiester bonds
C. peptide bonds
D. hydrogen bonds

Answers

Answer 1

The nucleotides that make up DNA and RNA are joined together into a chain with chemical interactions seen between sucrose foundation from one genotype and the hydroxyl group of the neighboring nucleotide.

Are phosphodiester bonds used to connect nucleotides?

After monomers are introduced into DNA, a phosphodiester bond forms between neighboring nucleotides, which is a covalent binding between a nucleotide's 5' phosphate group and its 3'-OH group (see below). This creates a "backbone" of phosphate-sugar-phosphate-sugar-phosphate for each strand of DNA.

What holds two nucleotides together?

The phosphodiester bond is the connection between two nucleotides that follow one another within the same DNA strand. Produced better results in DNA plus ribose in RN form the phosphodiester bond, which connects that 3' carbonyl group of one sugar molecule to the 5' carbon chain of another.

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Related Questions

Place the events of autonomic blood pressure regulation in the correct sequence. Blood flow returns to resting levels H
eart rate and stroke volume Baroreceptors in vessels increase firing rates Blood pressure increases Cardioaccoleratory center decreases nerve signals along sympathetic pathways Blood vessel wall stretches Sensory input sent to cardiovascular center

Answers

The events of autonomic blood pressure regulation in the correct sequence are

Blood pressure increasesBlood vessel wall stretchesBaroreceptors in vessels increase firing ratesSensory input sent to cardiovascular centerCardioacceleratory center decreases nerve signals along sympathetic pathwaysHerat rate and stroke  volume decreaseBlood flow returns to resting levels

The аutonomic nervous system аnd its sympаthetic аrm plаy importаnt roles in the regulаtion of blood pressure. Аutonomic regulаtion depends on three mаin components. Аfferent fibers continuously sense chаnges in blood pressure (bаroreceptors), blood content of oxygen, аnd other chemicаl signаls (chemoreceptors), pаin (sensory аfferents), аnd corticаl stimulаtion. These signаls аre integrаted in brаinstem centers thаt ultimаtely modulаte sympаthetic аnd pаrаsympаthetic outflows, which аre trаnsmitted to tаrget orgаns viа efferent fibers.

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Requires minimum safety standards for community water supplies?a.Safe Drinking Water Actb.Clean Water Actc.Clean Air Actd.Resource Conservation Recovery Act

Answers

The Safe Drinking Water Act mandates minimum safety standards for public water systems.

Option A is correct.

Who sets the minimum security requirements for public drinking water systems?

The Safe Drinking Water Act (SDWA), which was amended in 1986 and 1996, was passed into law by Congress in 1974 to protect our drinking water. According to the SDWA, the EPA must establish standards for the quality of drinking water and supervise the states, city municipalities, and municipal providers who enforce those criteria.

What three types of water quality standards are necessary?

A water standard of quality is made up of three parts the authorised beneficial use(s) of a water body or section of a water body; the water performance standards necessary to protect the use or use of that particular water body; and the traversed policy.

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why do camels have humps

Answers

Answer:

to store water and fat.

Explanation:

first

How does dna methylation age of human tissues and cell types

Answers

Answer: the humas tissue are the little bits of fleash

Explanation:i I'm toom to smart

Why are there so few ecosystems with more than four levels of consumers?
A) Predators at the highest trophic levels simply are not intelligent enough to hunt other top predators.
B) Consumers at these highest trophic levels typically form social groups that stop reproducing at high densities.
C) Top consumers compete with and kill each other with increasing population size.
D) Biomass decreases by about 90% at each trophic level, moving upward.

Answers

Few ecosystems have four or more tiers of consumers

D) Biomass decreases by about 90% at each trophic level, moving upward.

The correct option is D

There are so few ecosystems with more than four levels of consumers because biomass decreases by about 90% at each trophic level, moving upward. This means that there is less and less energy available as you move up the food chain, and fewer and fewer individuals can be supported at each higher trophic level. This limits the number of top predators that an ecosystem can support, as there simply may not be enough food to sustain them. In addition, top consumers often compete with and kill each other with increasing population size, further limiting the number of predators that an ecosystem can support. Therefore, it is rare to find ecosystems with more than four levels of consumers.

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Which supergroup of eukaryotes includes animals and fungi? Opisthokonta, Amoebozoa, Archaeplastida, Rhizaria, Chromalveolata, Excavata.

Answers

Opisthokonta - this group includes a diverse collection of single celled eukaryotes previously classified as protozoa. :)

can someone help me label the food pyramid!!

Answers

Note that the items, arranged according to the right order in the Pyramid is given as follows;

Apex predators (at the top of the food chain)Tertiary consumers (carnivores that eat other carnivores)Secondary consumers (carnivores that eat herbivores)Primary consumers (herbivores)Producers

What is the rationale for the above response?

The producers are at the base of the pyramid, followed by primary consumers that consume the producers.

Secondary consumers eat the primary consumers, and tertiary consumers eat the secondary consumers. Finally, at the top of the pyramid, there are the apex predators that eat other predators. The pyramid represents the energy flow from the producers to the top-level predators, with each level of the pyramid having less energy than the level below it.

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Entire plants can be cloned from individual somatic cells. What phenomenon does this demonstrate?a. differentiated cells contain masked mRNAb. differentiated cells retain all the genes of the zygotec. genes are lost during differentationd. the differentiated state is normally very unstable

Answers

Differentiated cells retain all the genes of the zygote. So entire plants can be cloned from individual somatic cells.

Is a zygote a differentiated cell?

Identity of cells, tissues, organs, and organisms are determined through the differentiation of cells during embryogenesis. A zygote is created once a sperm fertilizes an egg. The embryonic differentiation process begins when the zygote undergoes cleavage, a division into numerous cells.

The ability of individual somatic cells (cells that do not form pollen or eggs) to create whole, new clonal plants was demonstrated in early experiments with cloning plants, demonstrating that the somatic cells had not undergone irreversible changes to their genome from the original fertilized egg cell.

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What is RAS related GTP binding protein?

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RAS-related GTP-binding proteins (RAGs) are small GTPases involved in intracellular signaling pathways and cellular processes, with links to human disease.

RAS-related GTP-binding protein (RAG) is an important molecule present in our cells and is involved in many important cellular processes. They aid in the proper transport of substances in and out of cells, maintain cell shape and structure, and regulate gene expression. When RAG does not function properly, it can lead to a variety of health problems, including developmental disabilities and cancer. Researchers are studying RAG to understand how it works and find new ways to treat diseases caused by dysfunction. This knowledge can help improve the diagnosis and treatment of many conditions, ultimately improving patient outcomes.

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Phagocytosis, pinocytosis, and receptor-mediated endocytosis all involve:_________

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Phagocytosis, pinocytosis, and receptor-mediated endocytosis are a few examples of processes that infiltrate the plasma membrane.

What are plasma membranes employed for and why do they exist?

The body of a cell is made up of the cell membrane, also known as the plasma membrane. It also gives the cell a stable environment. And that membrane serves a variety of purposes. One is to feed the cell with nutrition while expelling harmful substances.

What substances comprise the plasma membrane?

Like all cellular membranes, the cell membrane is composed of proteins and lipids. The membrane's fundamental structural element is the bilayer, which establishes an impermanent barrier between both the two aqueous compartments.

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brayson’s son was diagnosed with having a chromosomal abnormality. if you were brayson’s friend, how would you explain the cause of chromosomal abnormalities?

Answers

If Brayson's son was found to have a chromosomal defect, the child would inherit either too many or too few chromosomes.

What are abnormalities in children?

Heart problems, neural tube defects, and Down syndrome are the three most prevalent serious birth defects. Although one or more genetic, viral, dietary, or environmental factors may contribute to birth abnormalities, it is frequently challenging to pinpoint the exact reasons. Some birth abnormalities are avoidable.

How is genetic abnormality?

When one or more genes are faulty, genetic disorders develop. Some genetic illnesses are inherited from parents and passed on to their offspring via their DNA. Sometimes spontaneous mutations in a gene's DNA result in a developing kid being impacted without a previous family history.

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The energy that produces a response in the sense organs is called a:________

Answers

Sensation, the force that causes the sensory organs to react stimulus.

What is the energy that causes the sense organs to react?

Energy that causes a sense organ to respond is known as a stimulus. Absolute threshold: The lowest stimulus intensity that a living thing can perceive. awareness of additional stimuli stimulation as opposed to a fixed quantity.

Sensory receptors: What are they?

A sensory receptor is a nerve ending that, when stimulated, delivers messages to the central nervous system. Sense Organs. Chemoreceptors react to substances through taste, odour, and internal alterations. When the temperature changes, thermoreceptors react.

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which has the thickest layer of peptidoglycan in the cell wall?

Answers

Gram-positive bacteria have a peptidoglycan layer that is significantly thicker (20 to 80 nanometers) than Gram-negative bacteria (7 to 8 nanometers).

The distinct big macromolecule known as peptididoglycan, also known as murein, is a polysaccharide made up of sugars and amino acids that forms a mesh-like layer outside the plasma membrane, the hard cell wall (murein sacculus) that is characteristic of most bacteria (domain Bacteria). : 66–67 Alternating residues of N-acetylglucosamine (NAG) and N-acetylmuramic acid make up the sugar component (NAM).

An oligopeptide chain with three to five amino acids is joined to the N-acetylmuramic acid. A layer that resembles a 3D mesh may be created by cross-linking one peptide chain to another peptide chain on another strand.

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Most water molecules that cross the plasma membrane do so by
A) diffusion through aquaporins.
B) diffusion through the plasma membrane.
C) diffusion through ion channels.
D) active transport by ion channels.
E) active transport by aquaporins

Answers

Aquaporins are used for diffusion, which is how most water molecules traverse the plasma membrane. either straightforward diffusion thru the lipid bilayer or water-selective enhanced diffusion via aquaporins.

What functions does your body's plasma serve?

55% of the total volume of your blood is made up of the liquid substance called plasma. In addition to circulating throughout the circulatory system, plasma is essential for your body's ability to heal after injury, deliver nutrients, remove waste, and prevent infection.

Your body makes plasma in what ways?

Intriguingly, no organ produces plasma, which makes up 55% of the blood overall. It is instead created from salts and water that are ingested.

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how would the amount of incoming solar radiation change at the equator if earth’s axis were vertical instead of tilted?

Answers

if the earth's axis were vertical rather than inclined, the equator would be It would result in more solar radiation pouring in.

An example of radiation

Whenever energy is exchanged, radiation is created. A material need not be radioactive in order to discharge radiation. Radiation is not produced by all element isotopes. Exposure covers elements like light, temperature, & alpha particles.

What causes radioactivity?

It can be made artificially by machinery or it can arise from radioactive nuclei that experience radioactive decay. The energy waves or charged particles that make up radiation leave their source. Radiation comes in several shapes, and each one has unique characteristics and results.

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identify whether the example describes an anabolic or catabolic pathway.
a. Bank Glycolysis converts one molecule of glucose to two molecules of pyruvate b. A protein molecule is constructed from amino acid subunits. c. Photosynthesis generales songe carbohydrates from C, and H.O. d. A nucleic acid molecule is broken down into nucleotide subunits.

Answers

(a) and (d) are the examples describes a catabolic pathway. (b) and (c) are the example describes an anabolic pathway.

a. The process of breaking down glucose into pyruvate, which releases energy, is known as glycolysis.

b. Because it uses energy to produce larger molecules from smaller ones, the process of generating a protein molecule from amino acid subunits is an anabolic route.

c. The process of photosynthesis, which uses energy from sunlight to create complex organic molecules (carbohydrates) from simpler inorganic ones (carbon dioxide and water), is anabolic in nature.

d. As a bigger molecule is broken down into smaller subunits, releasing energy in the process, the breakdown of a nucleic acid molecule into nucleotide subunits is a catabolic route.

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Enzymes are proteins, which catalyze chemical reactions.
true or false

Answers

It is accurate to say that proteins called enzymes catalyse chemical reactions.

Are the proteins that catalyst chemical reactions called enzymes?

Catalysts are substances that speed up chemical reactions without actually taking part in them. Enzymes serve as catalysts for biological reactions in living things. The majority of enzymes are proteins, although certain RNA molecules can also function as enzymes.

All enzymes catalyst processes, right?

29 January 2021 posted. Both enzymes and catalysts influence a reaction's pace without getting consumed during the process. However, not all catalysts are enzymes, and not all known enzymes are catalysts. Many different chemical reactions can be catalysed by a particular enzyme. The secretory cells create the enzymes, which are essentially proteins.

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the small bulge at the end of the axon that sends messages to other neurons are called by?

Answers

Terminal buttons are the tiny protrusions at the end of axons that communicate with neighboring neurons.

What is neuron and its function?

The basic building blocks of the nervous system and brain are neurons (also known as neurones or nerve cells). Brain cells are the cells that receive sensory information from the outside world, give control signals to our muscles, and transform and relay electrical signals at each stage along the way.

What is the largest neuron?

With a width of 1.1 mm, this R2 cell seems to be the biggest neuron ever captured on camera. When this cell is isolated, a record-breaking 1.965 g of total RNA was produced.  

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What is a nursing diagnosis for ineffective coping?

Answers

Ineffective Coping related to stress and anxiety as evidenced by increased agitation, inability to relax, poor sleep patterns, and negative coping mechanisms such as substance use or social withdrawal.

What is Diagnosis?

A diagnosis is the identification of a particular disease or condition based on its signs and symptoms, medical history, and diagnostic tests. In medicine, a diagnosis is an essential step in providing appropriate treatment and care for a patient. A nursing diagnosis, specifically, is a clinical judgment made by a nurse to describe a patient's response to actual or potential health problems or life processes that the nurse is licensed and competent to treat. It provides the basis for the selection of nursing interventions to achieve outcomes for which the nurse has accountability.

Other possible nursing diagnoses for ineffective coping may include:

Anxiety related to stressors and insufficient coping strategies

Risk for self-harm related to ineffective coping and overwhelming stress

Disturbed sleep pattern related to high levels of stress and anxiety

Impaired social interaction related to social withdrawal and ineffective coping mechanisms

Ineffective impulse control related to poor coping skills and heightened emotions.

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Chordates possess several distinguishing characteristics that separate them from other animal groups. Select all of the features that one would use to classify members into this phylum. a) postanal tail. b) cranium. c) pharyngeal slits. d) notochord. e) dorsal hollow nerve cord. f) vertebral column.

Answers

The distinguishing characteristics of chordates that separate them from other animal groups are: Postanal tail, Notochord,  Dorsal hollow nerve cord and Pharyngeal slits. Option A, C, D and E is correct.

Postanal tail: This is a tail that extends beyond the anus and is present in the embryonic stage of all chordates, and some retain it in the adult stage.

Notochord: This is a flexible rod-like structure that runs along the dorsal (back) side of the body and provides support. The notochord is present in the embryonic stage of all chordates.

Dorsal hollow nerve cord: This is a hollow cord that runs along the dorsal side of the body and develops into the central nervous system, which includes the brain and spinal cord.

Pharyngeal slits: These are openings in the pharynx, the part of the digestive system that lies between the mouth and the esophagus. In aquatic chordates, the slits function in filter-feeding and respiration.

Based on these characteristics, the features that one would use to classify members into the phylum Chordata are a, b, c, and d. While some chordates may also possess e and f, they are not required characteristics for classification into this phylum.

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Depiction of the plasma membrane as a semifluid phospholipid bilayer with proteins and carbohydrates attached to lipids and/or proteins?

Answers

Fluid Mosaic model. Since the cell membrane is composed of a variety of distinct molecules that are dispersed throughout the membrane.

Scientists describe how the membrane appears and operates using a fluid mosaic model. A mosaic, or pattern made up of several sorts of molecules, can be seen if you zoom in on the cell membrane. Similar to icebergs floating in the ocean, these molecules are constantly moving in two dimensions in a fluid manner. It is impossible to create a barrier that is entirely impenetrable due to the motion of the molecular mosaic.

Cell membrane fluidity is primarily influenced by three variables:

Temperature.Chloestrolfats, both saturated and unsaturated.

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What is 20610 cpt code ?

Answers

20610 is the CPT code for Arthrocentesis, aspiration and/or injection; major joint or bursa (e.g., shoulder, hip, knee, subacromial bursa).


The 20610 CPT code is a medical procedure code that refers to "Arthrocentesis, aspiration and/or injection, major joint or bursa (eg, shoulder, hip, knee, subacromial bursa); without ultrasound guidance".

This procedure involves the removal of fluid from a joint or bursa using a needle and syringe. The fluid can be removed for diagnostic purposes or to relieve pain and pressure.

This code is commonly used for procedures performed on the shoulder, hip, knee, or subacromial bursa. It is important to note that this code does not include ultrasound guidance, which would be indicated with a different CPT code.

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Enzymes are typically what type of biomolecule/macromolecule?

Answers

Enzymes are type of macromolecule protein

What is an enzyme?

Macromolecules are long chains which composed of simpler molecule. The simple molecule is named as monomer or building block. There are four major types of macromolecules, carbohydrates, protein, lipid and nucleic acid. 

Amino acid is a building block that make up protein. Proteins play many roles in a cell or organism. A few examples of protein, are hormone, antibody, hemoglobin and enzymes. Enzyme acts as a catalyst which accelerate the rate of chemical reaction. Enzyme are proteins comprised of amino acids which linked together into one or more polypeptide chains.

Thus, enzyme belong in the category of proteins.

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what options do butterflies have for regulating their body temperature?

Answers

Butterflies lack the ability to control their body temperatures since they are cold blooded (ectothermic). They must instead rely on behavioural instincts to help them warm up so they may fly.

What is Ectothermic ?

Any species whose ability to regulate its internal temperature depends on environmental factors like sunlight or a warm rock surface. Fishea, amphibians, reptiles, and invertebrate are the ectotherms.

What is the definition of instinctual behaviour?

When referring to behaviours which are not learnt, such as activities you obviously know when to do in the first time, people frequently use the terms "innate" or "instinctive." It's critical to act instinctively to ensure the future of your genes and, ultimately, your species.

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which part of the neuron communicates an electrical signal to target tissue?

Answers

Axon would communicates an electrical signal to target tissue. Every nerve in the body has an axon.

The bigger the size, the faster it sends messages to the body. Usually, axons can be found in the innermost nerves and are sheathed in myelin. Myelin is a white fatty protein complex that serves as insulation for axons. In addition, myelin can also help when the body will send signals long distances.

This means that myelin is more commonly found in neurons that connect different brain regions, than in neurons whose axons stay in one area. It functions to transmit messages between neurons. It also has side branches known as collateral axons, so they can transmit messages to several neurons at once.

these branches will also be divided into smaller branches known as axon terminals or nerve terminals. Each terminal has a synapse where neurotransmitters can transmit messages and receive messages sent.

In other words, the axon makes a nerve cell capable of sending electrical and chemical messages to other nerves, glands, and muscles, to make communications in this process.

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the-_____gland is considered the master gland of the endocrine system.

Answers

Answer:

The Pituitary Gland

Explanation:

The pituitary gland is sometimes called the "master" gland of the endocrine system because it controls the functions of many of the other endocrine glands. The pituitary gland is no larger than a pea, and is located at the base of the brain.

The gonads produce steroids. The specific steroid-producing organelle in gonad cells is, ribosomes. lysosomes. smooth endoplasmic reticulum. mitochondria. contractile vacuole.

Answers

Answer:

smooth endoplasmic reticulum is the correct answer.

Explanation:

which theory of inheritance states that offspring have a mix of characteristics of their parents

Answers

Combining Inheritance Theory According to the blended inheritance concept, physical features (or phenotypes) of kids are an intermediate of the parents.

For example, if a tall man and a short woman conceive a kid, this theory predicts that their child would be of intermediate height in relation to her parents. This is the belief that children have a combination of their parents' qualities. Mendel observed plants in his own garden that were not a cross between the parents. A tall plant and a small plant, for example, produced offspring that were either tall or short, but not middle in height.

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(04.01 MC)
What percent of energy is transferred from the sun to the level indicated?
O 50 percent
O 100 percent
O90 percent
O 10 percent

Answers

100 percent of energy is transferred from the sun to the level of plants and as suggested by Lindeman's 10% law, only 10% of energy is transferred to the next trophic level, hence option B is correct.

How energy is transferred in the energy pyramid?

10% of the total energy in the trophic level before is moved from one trophic level to the next in the food pyramid. This is due to the fact that each trophic level's creatures utilize and store some of their energy.

The energy for the plants, which are the main producers, comes not from the trophic levels but instead directly from sunlight. Consequently, 100% of the sun's energy is delivered to the plants at the base of the food pyramid.

Therefore, 100 percent of energy is transferred from the sun to the level indicated.

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What are abdominal quadrants and organs ?

Answers

The abdomen is divided into four quadrants: the right upper quadrant, the left upper quadrant, the right lower quadrant, and the left lower quadrant. These quadrants are used to help identify the location of organs and structures within the abdomen.

The right upper quadrant (RUQ) contains the liver, gallbladder, right kidney, and portions of the small and large intestines.

The left upper quadrant (LUQ) contains the stomach, spleen, left kidney, and portions of the small and large intestines.

The right lower quadrant (RLQ) contains the appendix, cecum, and portions of the small and large intestines.

The left lower quadrant (LLQ) contains portions of the small and large intestines, as well as the left ovary and fallopian tube in women.

It is important to know the location of these abdominal quadrants and the organs they contain in order to accurately diagnose and treat medical conditions.

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Only two forces act on an object (mass = 3. 00 kg), as in the drawing. Find the magnitude and direction (relative to the x axis) of the acceleration of the object. Lines and are parallel lines cut by a transversal. Use the lines and the angles formed to select all that are true statements. Select 3 correct answer(s)a. Angle 3 and Angle 6 are vertical angles.b. Angle 1 and Angle 5 are corresponding angles.c. Angle 6 and Angle7 are vertical angles.d. Angle 7 and angle 8 are supplementary angles.e. Angle 2 and angle 4 are alternate interior angles.f. Angle 1and angle 4 are same side interior angles. Discuss the conversation between Randy and Ponyboy. Which of these statements accurately describes a similarity between sharks and rayfinned fishes?A) The skin is typically covered by flattened bony scales.B) They are equally able to exchange gases with the environment while stationary.C) They are highly maneuverable due to their flexibility.D) They have a lateral line that is sensitive to changes in water pressure.E) A swim bladder helps control buoyancy. Given the expression: 8x2 + 28x - 16Part A: What is the greatest common factor? Explain how to find it. (3 points)Part B: Factor the expression completely. Show all necessary steps. (5 points)Part C: Check your factoring from Part B by multiplying. Show all necessary steps. (2 points) Historical ruin in Crete believed to be home to the Minotaur - Daily Themed Crossword what modern invention does waterman state is possibly the biggest challenge in landscape architecture? An article in forbes noted that the intercounty connector toll road that connects two counties in maryland was not generating as much toll revenue as predicted. At that time, the toll rate was $8 for a passenger car making a round trip from end to end on the tollway during rush hour. how did life change for wemon during world war 2 Of the groups of people banned under the Immigration Act of 1903, which seems the most unfair/prejudiced and why? Which option best describes recombinant DNA? Responses a DNA from an organism that has been rearranged in a different order. b DNA that has been modified by the removal of unwanted genesc copies of DNA produced in a lab setting to mass produce proteins copiesd genetic material that incorporates DNA from multiple organismsanswer in a letter not in a long sentence explanation without telling which 1 is correct. pls do it fast 10 points a 250 ml sample of oxygen is collected over water at 25c and 760.0 torr pressure. what is the pressure of the dry gas alone? ( vapor pressure of water at 25c is on chart above) Examples Of Money Going Out That Can Be Recorded Using The Expense Or Check Onscreen Forms Include All Of The Following Except: A Rent Expense B. Payroll Expense C. Insurance Expense D. Legal Services michael recently suffered a stroke to his . now he is unable to perceive accurately the emotions of others. please choose the correct answer from the following choices, and then select the submit answer button. answer choices somatosensory cortex right hemisphere corpus callosum left hemisphere INSTRUCTION:Write photo caption with thefollowing picture.*Kicker - 1-3 words*Headline*Caption - 5-7 wordsWhat: Senior Dance nightWho: Senior High School studentsWhere: Grace of ShekinahSchool GymnasiumWhen: February 11Pls po i really need help ASAP. I'll mark brainliest who answered po. SOLVE FOR X THANK U VERY MUCH!!! The volume occupied by 9 x 1023 molecules of nitrogen gas at STP is closest to:___________a. 1.5 Lb. 22.4 Lc. 33.6 Ld. 0.5 L A car starts from rest on a curve with a radius of 130m and tangential acceleration of 1.3m/s2 .Through what angle will the car have traveled when the magnitude of its total acceleration is 2.2m/s2 ? A trait whose development requires the action of thousands of genes but whose variation is due to variation at only two loci isA.) ExtranuclearB.) DigenicC.) PolygenicD.) Meristic 'cell-type specific cis-eqtls in eight brain cell-types identifies novel risk genes for human brain disorders" who wrote this?