Antibiotic resistant bacteria are becoming more and more prevalent, leaving us in desperate need of novel antimicrobial compounds to replace the drugs that are now obsolete in our hospitals and medical clinics. A high throughput screen of 700,000 compound library has allowed you to identify one molecule capable of killing extensively drug resistant tuberculosis at concentrations 1000X lower than currently used therapeutics. The only problem is, you don't know the molecular target. Develop an experimental strategy to identify the molecular target of your new antibiotic. Make sure to use some of the techniques described in the chapters covered throughout Units 1-6, and be creative. There isn't one correct answer!'

Answers

Answer 1

Answer:

Explanation:

We know the molecules equipped for killing broadly drug-resistant tuberculosis. This requires that we build up an experimental test system to distinguish the molecular target of your new antibiotic.

These steps include:

Gather proteomics data of tuberculosis and gather structural data of all proteins inside it.  

At that point perform molecular docking with the molecule you as of now have.  

This can yield the molecular target for the new antibiotic.


Related Questions

Most professional sportsmen and sportswomen do not smoke.
Explain why:

Answers

um I think because it’s is bad for your lungs and breathing aka your health!

what is xylem and phloem in science?​

Answers

Answer:

The xylem is one of the two types of tissue transported from the vascular plants, the other being the phloem.

Answer:

Xylem and phloem Plants have tissues to transport water, nutrients and minerals. Xylem transports water and mineral salts from the roots up to other parts of the plant, while phloem transports sucrose and amino acids between the leaves and other parts of the plant. Xylem and phloem in the center of the plant root

Explanation:

Hope this helps!!

What's the side effects of the flu vaccine nasal spray

Answers

Runny nose, headaches and nausea

anyone wanna zoooom

ʕ´ڡ`*ʔʕ´ڡ`*ʔʕ´ڡ`*ʔ​

Answers

Answer:

No Busy. Sorry.

Explanation:

You are trying to determine the mode of inheritance for the mutant curly-winged phenotype in Drosophila. You cross pure-bred wild-type flies with pure-bred mutant (curly-winged) flies and notice that all of F1 has curly wings. You make the scientific hypothesis that the curly-winged phenotype is autosomal dominant to the wild-type wing phenotype. a. If your scientific hypothesis is correct, what ratios would you expect to see in your F2 generation?

Answers

Answer:

The correct answer is - In F2 generation we should get a 3:1 ratio of phenotypes. 3 curly dominant, 1 wild type recessive.

Explanation:

In the given case, the cross between pure-bred wild-type flies with pure-bred mutant (curly-winged) flies and it is found that in F1 generation all offsprings are curly wings which means curly wings are dominant over wild-type.

let assume w gene is responsible for wild type and W gene is responsible for the curly wings which is dominant over wild type

     W   W

w    Ww  Ww

w  Ww   Ww

now on self crossing

     W   w

W   Ww  Ww

w   Ww  ww

In f2 generation there are 75% chances of the curly wing and 25% chances of wild type or the ratio of phenotype would be 3:1

Probes that bind under very stringent hybridization conditions resulting in the differential binding over one nucleotide are called ________. Probes that bind under very stringent hybridization conditions resulting in the differential binding over one nucleotide are called ________. short, variable repeats VNTRs microsatellites allele-specific oligonucleotides (ASOs) generation-specific probes

Answers

Answer:

allele-specific oligonucleotides (ASOs)

Explanation:

An allele-specific oligonucleotide (ASO) is a piece of synthetic DNA that is short and usually a complementary to the sequence of a target DNA, It is an oligonucleotide of 15–21 nucleotide bases in length.

It acts as a probe in southern blot assay or simpler Dot blot assay to identify the presence of a target.

It is an important research tool in genetic testing, forensics, and Molecular Biology.

The probes can detect a difference of as little as 1 base in the sequence targeted.

In the figure above which fatty acids are most likely to be solid at room tempearture

Answers

What figure? U have to attach something so I can help

answer sheet of Grade 10 science what I have Learned module 2 Quarter 3​

Answers

i’m sorry but i would like to help but this got me lost

The Chesapeake Bay, which is along the coast of the Eastern U.S., is the largest estuary in the country. Many rivers, including the Potomac, empty into this section of the Atlantic Ocean.

During the 1970s, areas of the bay were found to have low levels of oxygen and could not support life. What was the cause of this problem?

Answers

Answer: B. High levels of nitrogen and phosphorus from agriculture runoff, sewage, and etc

Explanation:

i did it off study island

What do all fossil fuels have in common?
O A. They are all burned when used as energy sources.
O B. They are all renewable energy sources.
O C. They all produce oxygen as a combustion product.
O D. They all contain methane.

Answers

All fossil fuels have common feature that they are all burned when used as energy sources.

Fossil fuels Fossil fuels are made from decomposing plants and animals. These fuels are hydrocarbon- containing materials which are found in Earth's crust.Examples of fossil fuels include coal, oil, petroleum hydrocarbons, natural gas etc.They all are burned for energy.They all have hydrogen and carbon in common.They are non-renewable energy sources.They all have different composition other than having hydrocarbon group.All produces different combustion products according to their composition.

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Pls help with this it really easy also don’t worry about the dot I didn’t mean to press it

Answers

Answer:

I think B, some bone ailments are congenital

Answer:

The second one

Explanation:

10
Obsidian and pumice are extrusive igneous rocks and lack crystals. Why is it that these rocks
do not have crystals? *
(1 Point)
There were no minerals in the magma
The lava cooled slowly deep inside the Earth
The lava cooled too quickly above the Earth
The pressure was too great to make any crystals

Answers

Answer:

Hi  to the mountain

Explanation:

how do scientists use rock layers to date fossils ? USE IN YOUR OWN WORDS.

40 POINTS DONT SKIP !

Answers

Answer:

By comparing a fossil to similar rocks and fossils of known ages, relative dating can be used to estimate its age. Absolute dating is a method of determining the precise age of a fossil by using radiometric dating to measure the decay of isotopes, either within the fossil itself or, more commonly, the rocks that surround it.

Explanation:

Which of the following best describes a population?
A. All of the seagulls that live along the coast
B. All of the seagulls that live along the coast, the fish they eat, and the water
C. All of the seagulls that live along the coast and the fish they eat
D. All of the seagulls that live along the coast, as well as the sand and the water

Answers

Answer:

I think that the answer might be C

Answer:

I mean it looks like B to me but I could be wrong. :)

Explanation:

how does the anti tetanus serum prevent tetanus

Answers

Answer: It is used to prevent tetanus in those who have a wound that is at high risk and have not been fully vaccinated with tetanus toxoid. It is also used to treat tetanus along with antibiotics and muscle relaxants. It is given by injection into a muscle.

Explanation:

a medication made up of antibodies against the tetanus toxin. It is used to prevent tetanus in those who have a wound that is at high risk and have not been fully vaccinated with tetanus toxoid. It is also used to treat tetanus along with antibiotics and muscle relaxants.

How can someone see in a dim room

Answers

Wait like see in a dark room

A member of a population of genetically identical organisms that were produced from a single cell.



a
bacteriophage
b
clone
c
transgenic
d
restriction enzyme

Answers

The correct answer is B

Answer the following questions:
1. How does motion help us in our daily life?
2. How would you be able to help those people who cannot move due to
paralysis​

Answers

Answer:

1. Lack of motion is death. Movement is a vital nutrient to your body, just as much as food, water, and oxygen.

2. Potassium supplements can prevent attacks of paralysis.

Explanation:

In cellular reproduction, ___ ALWAYS occurs in 5’ to 3’ direction

Answers

Answer:

DNA replication

Explanation:

DNA replication is the process whereby the genetic material (DNA) duplicates itself into two identical copies. This process must occur prior to any cellular division (meiosis or mitosis) in order to ascertain that each daughter cell gets an even and correct amount of DNA.

The process of DNA replication begins with the unwinding of the double stranded DNA molecule into two single strands of DNA. One strand called leading strand runs from 3'-5' while the other strand runs from 5'-3'. However, DNA replication proceeds in the 5'-3' direction.

In the fantastic Jillalope, the offspring of a true-breeding black parent and a true-breeding white parent all appear gray. When these gray offspring are crossed among themselves, their offspring always appear in a ratio of 1 black : 2 gray : 1 white. Upon close examination of the coats with a magnifier, each hair of a gray animal has closely-spaced alternating black spots and white spots, but no gray spots. What is the mode of inheritance

Answers

Answer:

Co-dominance

Explanation:

Due to technical problems, you will find the  complete explanation in the attached files

Comparing the fetus's of a chicken and human is evidence for

a. geographic distribution
b. homologous structures
c. embryology
d. fossil record​

Answers

The answer to ur question is a

Why is it important that tissues are composed of specialized cells?

Answers

Cell specialization allows new cells to develop into a range of different tissues, all of which work together to make living organisms function as a whole. The process of cell specialization exactly how cells develop into their diverse forms is complex.

how does the structure of simple cuboidal connect to its function

Answers

Answer:

Simple cuboidal epithelial tissue is specialized for diffusion and absorption. The reason our kidneys function the way they do is because of the movement of water and salts in and out of the kidney tubules.Likewise, the cuboidal shape of the cells allows greater surface area for absorption to take place.

what is the time of growth between cell divisions called

Answers

Answer:The time growth between cell divisions is called interphase.

Explanation:


There's no such thing as "solid ground" agree or disagree

Answers

Disagree should be it

Why Mike a scientist repeat any spearmint if he she didn’t make a mistake in the first one?

Answers

Answer:

Explanation:

i think its so that there wont be any mistake in when they are collecting their data which simplifys to  Experiments are often replicated or repeated even when no obvious mistake was visible

which is NOT a apart of the cell theory

Answers

Answer: Microscopic organisms are not made of cells.

All things that are living are made of cells.

Which of the following lists three popular chuck cuts?
short ribs, pot roast, prime rib
O pot roast, prime rib, blade steak
O prime rib, blade steak, short ribs
blade steak, short ribs, pot roast
NEED HELP NOW I NEED TO BE DONE BY THE WEEKEND!!!

Answers

Answer:

tbh pot roast, prime rib and blade steak are your best options

Short ribs, pot roast, prime rib are three popular chuck cuts. Therefore, option (A) is correct.

What is chuck cut?

Chuck is a cut of beef that is taken from the shoulder and neck area of the cow. It is a relatively inexpensive cut that is known for its rich, beefy flavor and can be prepared in a variety of ways. The chuck is composed of several different muscles, each with its unique characteristics and tenderness.

Some popular chuck cuts include:

Pot Roast: A boneless cut taken from the shoulder, it is perfect for slow-cooking methods such as braising or stewing.

Short Ribs: These are taken from the rib section of the chuck and are known for their meaty and flavorful taste. They can be grilled, braised or slow-cooked.

Blade Steak: Also known as flat iron steak, it is a cut taken from the shoulder blade. It has a rich, beefy flavor and can be cooked in a variety of ways, including grilling, broiling, and pan-frying.

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What happens to a
pathogen that has been flagged by an antibody?

Answers

The antibody does a couple of things; it’ll interfere with the pathogen’s movement. Think of it like a kid that is holding onto their parent’s legs. Said parent will slow down even more if more kids (antibodies) latch onto them. It’ll also act as a little flag for phagocytes, signaling that whatever they’re latched onto is something to eat. I hope this is enough to help out!

Please help me with this biology thing.

Answers

Answer:

Answer:

1.

a)dd

b) dd

c) 0%

2.

a) 25%

b) 75%

c) 25%

3.

a) 03

b) 0

c) tt

4.

a) FF x ff OR FF x Ff OR FF x FF

b) Because all the children have freckles

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